| UniProt/SwissProt ID: | RXFP1_HUMAN |
| Description: | relaxin/insulin-like family peptide receptor 1 [Source:HGNC Symbol;Acc:19718] |
| Location: | chr4 q32.1 |
| Node attribute: | receptor |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| T507 | LLTFLtLEKYI | 7tm_1; TM | PhosphoSitePlus |
| T504 | SVLLLtFLTLE | 7tm_1; TM | PhosphoSitePlus |
| Dephosphorylation site |
| RXFP1_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000303248 | S123L | COSMIC | Melanoma | 21946352 | ENSP00000303248 | A613T | COSMIC | Melanoma | 21946352 | ENSP00000303248 | R469C | COSMIC | Melanoma | 21946352 | ENSP00000303248 | P122L | COSMIC | Melanoma | 21946352 | ENSP00000303248 | E509K | COSMIC | Melanoma | 21946352 | ENSP00000303248 | S269F | COSMIC | Melanoma | 21946352 | ENSP00000303248 | P546S | COSMIC | Melanoma | 21946352 | ENSP00000303248 | S609N | COSMIC | Hepatocellular Carcinoma | 21822264 |
| Differential expressed protein |
| RXFP1_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| RXFP1_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| REL3_HUMAN | RXFP1_HUMAN | ligand -> receptor | HPMR |
| REL2_HUMAN | RXFP1_HUMAN | ligand -> receptor | HPMR |
| REL1_HUMAN | RXFP1_HUMAN | ligand -> receptor | HPMR |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04080 | Neuroactive ligand-receptor interaction |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0004930 | G-protein coupled receptor activity | IEA | molecular_function |
| GO:0004930 | G-protein coupled receptor activity | IDA | molecular_function |
| GO:0030154 | cell differentiation | IEA | biological_process |
| GO:0007188 | adenylate cyclase-modulating G-protein coupled rec | IEA | biological_process |
| GO:0060658 | nipple morphogenesis | IEA | biological_process |
| GO:0060427 | lung connective tissue development | IEA | biological_process |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0030198 | extracellular matrix organization | IEA | biological_process |
| GO:0007186 | G-protein coupled receptor signaling pathway | IEA | biological_process |
| GO:0005886 | plasma membrane | TAS | cellular_component |
| GO:0016021 | integral to membrane | IEA | cellular_component |
| GO:0007567 | parturition | IEA | biological_process |
| GO:0046872 | metal ion binding | IEA | molecular_function |
| GO:0042562 | hormone binding | IEA | molecular_function |