Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:RUNX1_HUMAN
Description:runt-related transcription factor 1 [Source:HGNC Symbol;Acc:10471]
Location:chr21 q22.12
Node attribute:substrate; TF

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S295LSSRLsTAPDLPhosphoSitePlus
S225PNPRAsLNHSTPhosphoSitePlus
S17RFTPPsTALSPPhosphoSitePlus; HPRD; phosphoELM
S276PATPIsPGRASHIPK2HPRD
S268SIASPsVHPATPhosphoSitePlus
T312ASGMTtLSAELHPRD
Y254SPPWSyDQSYQPhosphoSitePlus
S191QTKPGsLSFSEPhosphoSitePlus
S44RFTPPsTALSPHPRD
T230SLNHStAFNPQHPRD; phosphoELM
S212TAMRVsPHHPAPhosphoSitePlus
T296SSRLStAPDLTPhosphoSitePlus
S263YQYLGsIASPSPhosphoSitePlus
S329GAFTYsPTPVTPhosphoSitePlus
S266LGSIAsPSVHPPhosphoSitePlus
S397VGGERsPPRILRunxIPhosphoSitePlus
T285ASGMTtLSAELHPRD
S21PSTALsPGKMSPhosphoSitePlus; HPRD; phosphoELM
Y258SYDQSyQYLGSPhosphoSitePlus
S238NPQPQsQMQDTPhosphoSitePlus
S48PSTALsPGKMSHPRD
S50RSGDRsMVEVLRuntPhosphoSitePlus
S319SAELSsRLSTAHPRD
S292SAELSsRLSTAPhosphoSitePlus; HPRD
S229ASLNHsTAFNPHPRD; phosphoELM
T41TSRRFtPPSTAHPRD
Y453AVWRPy_____RunxIPhosphoSitePlus
S423SLPNQsDVVEARunxIPhosphoSitePlus
S318LSAELsSRLSTHPRD
T311RASGMtTLSAEHPRD
T14TSRRFtPPSTAPhosphoSitePlus; HPRD; phosphoELM
S256ASLNHsTAFNPHPRD
S253PSPPWsYDQSYPhosphoSitePlus
T257SLNHStAFNPQHPRD
S276PATPIsPGRASPhosphoSitePlus
S249RQIQPsPPWSYPhosphoSitePlus
T18FTPPStALSPGPhosphoSitePlus; HPRD; phosphoELM
S291LSAELsSRLSTHPRD
T331FTYSPtPVTSGPhosphoSitePlus
T45FTPPStALSPGHPRD
S257WSYDQsYQYLGPhosphoSitePlus
S249RQIQPsPPWSYHIPK2HPRD
S433AEGSHsNSPTNRunxIPhosphoSitePlus
T284RASGMtTLSAEHPRD
T219HHPAPtPNPRAPhosphoSitePlus
T273SVHPAtPISPGPhosphoSitePlus

Dephosphorylation site
RUNX1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000300305G165CCOSMICLymphoma21339757
ENSP00000300305W106LCOSMICLymphoma20678218
ENSP00000300305G59DCOSMICLymphoma17485549
ENSP00000300305E223GCOSMICLymphoma15142876
ENSP00000300305R237KCOSMICLymphoma20644105
ENSP00000300305D198NCOSMICLymphoma21909114
ENSP00000300305Q397RCOSMICLymphoma17910630
ENSP00000300305R204*COSMICLymphoma20644105
ENSP00000300305L98fs*24COSMICLymphoma18250304
ENSP00000300305R166QCOSMICLymphoma20421268
ENSP00000300305S141*COSMICLymphoma18202228
ENSP00000300305L175PCOSMICLymphoma21339757
ENSP00000300305Y380*COSMICLymphoma20678218
ENSP00000300305P183ACOSMICLymphoma15142876
ENSP00000300305P125fs*8COSMICLymphoma17550866
ENSP00000300305I193TCOSMICLymphoma14615365
ENSP00000300305P425LCOSMICLymphoma20644105
ENSP00000300305K110RCOSMICLymphoma21339757
ENSP00000300305S226*COSMICLymphoma17485549
ENSP00000300305M52KCOSMICLymphoma20421268
ENSP00000300305R162KCOSMICLymphoma21531982
ENSP00000300305I177TCOSMICLymphoma11921279
ENSP00000300305Q208*COSMICLymphoma21339757
ENSP00000300305G69RCOSMICLymphoma12393679
ENSP00000300305H105YCOSMICLymphoma20678218
ENSP00000300305V132LCOSMICLymphoma20520634
ENSP00000300305R250HCOSMICLymphoma15142876
ENSP00000300305M466LCOSMICLymphoma17910630
ENSP00000300305N146ICOSMICLymphoma20008300
ENSP00000300305L56SCOSMICLymphoma21531982
ENSP00000300305A120fs*2COSMICLymphoma15180860
ENSP00000300305L339fs*143COSMICLymphoma15142876
ENSP00000300305R201QCOSMICLymphoma20678218
ENSP00000300305S94ICOSMICLymphoma15142876
ENSP00000300305A147DCOSMICLymphoma17550866
ENSP00000300305N96SCOSMICLymphoma17485549
ENSP00000300305R201*COSMICLymphoma21339757
ENSP00000300305Q185HCOSMICLymphoma15142876
ENSP00000300305S318fs*10COSMICLymphoma14615365
ENSP00000300305R204QCOSMICLymphoma20421268
ENSP00000340690H58NOMIMLeukemia12200707 10068652
ENSP00000300305Q154*COSMICLymphoma20008300
ENSP00000300305Q262*COSMICLymphoma21531982
ENSP00000300305R76SCOSMICLymphoma12529654
ENSP00000300305Q266*COSMICLymphoma20421268
ENSP00000300305S100FCOSMICLymphoma20421268
ENSP00000300305P200SCOSMICLymphoma12393679
ENSP00000300305R107CCOSMICLymphoma21339757
ENSP00000300305S400*COSMICLymphoma21531982
ENSP00000300305R320*COSMICLymphoma20421268
ENSP00000300305H85NCOSMICLymphoma10068652
ENSP00000300305S141LCOSMICLymphoma17485549
ENSP00000300305P113LCOSMICLymphoma20421268
ENSP00000300305L112PCOSMICLymphoma17485549
ENSP00000300305D160ECOSMICLymphoma20421268
ENSP00000300305D75YCOSMICLymphoma19773259
ENSP00000300305R166*COSMICLymphoma20421268
ENSP00000300305K171NCOSMICLymphoma17485549
ENSP00000300305Y281*COSMICLymphoma15142876
ENSP00000300305G170RCOSMICLymphoma20678218
ENSP00000300305A315VCOSMICHead and Neck Cancer21798893
ENSP00000300305G199RCOSMICLymphoma17910630
ENSP00000300305F259fs*52COSMICLymphoma15142876
ENSP00000300305S141fs*4COSMICLymphoma15142876
ENSP00000300305L144PCOSMICLymphoma12874780
ENSP00000300305A60VCOSMICLymphoma12399980
ENSP00000300305V238fs*16COSMICLymphoma15142876
ENSP00000300305T111NCOSMICLymphoma20421268
ENSP00000300305R157fs*19COSMICLymphoma14615365
ENSP00000300305F163YCOSMICLymphoma17910630
ENSP00000300305F116SCOSMICLymphoma15613106

Differential expressed protein
RUNX1_HUMAN is not differential expressed protein.

Hyperphosphorylation site
RUNX1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
HIPK2_HUMANRUNX1_HUMANkinase -> substrateHPRD
RUNX1_HUMANIL3_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05220Chronic myeloid leukemia
hsa05200Pathways in cancer
hsa05221Acute myeloid leukemia
hsa05202Transcriptional misregulation in cancer

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0002318myeloid progenitor cell differentiationIEAbiological_process
GO:0030182neuron differentiationIEAbiological_process
GO:0045944positive regulation of transcription from RNA polyIEAbiological_process
GO:0003677DNA bindingIEAmolecular_function
GO:0001701in utero embryonic developmentIEAbiological_process
GO:0003700sequence-specific DNA binding transcription factorIEAmolecular_function
GO:0001501skeletal system developmentIEAbiological_process
GO:0005634nucleusIEAcellular_component
GO:0071336regulation of hair follicle cell proliferationIEAbiological_process
GO:0071425hematopoietic stem cell proliferationTASbiological_process
GO:0042803protein homodimerization activityIDAmolecular_function
GO:0005524ATP bindingNASmolecular_function
GO:0035162embryonic hemopoiesisIEAbiological_process
GO:0030853negative regulation of granulocyte differentiationIMPbiological_process
GO:0003677DNA bindingIDAmolecular_function
GO:0060216definitive hemopoiesisIEAbiological_process
GO:0030097hemopoiesisIDAbiological_process
GO:0046982protein heterodimerization activityIDAmolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0030099myeloid cell differentiationIDAbiological_process
GO:0043231intracellular membrane-bounded organelleIDAcellular_component
GO:0005634nucleusIDAcellular_component
GO:0070491repressing transcription factor bindingIEAmolecular_function
GO:0030854positive regulation of granulocyte differentiationIMPbiological_process
GO:0048666neuron developmentIEAbiological_process
GO:0006355regulation of transcription, DNA-dependentIEAbiological_process
GO:0008134transcription factor bindingIDAmolecular_function
GO:0001889liver developmentIEAbiological_process
GO:0000975regulatory region DNA bindingIDAmolecular_function
GO:0031069hair follicle morphogenesisIEAbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0048266behavioral response to painIEAbiological_process
GO:0048935peripheral nervous system neuron developmentTASbiological_process
GO:0006351transcription, DNA-dependentIEAbiological_process
GO:0045944positive regulation of transcription from RNA polyIDAbiological_process
GO:0009966regulation of signal transductionIEAbiological_process
GO:0045766positive regulation of angiogenesisISSbiological_process
GO:0005604basement membraneIEAcellular_component
GO:0005515protein bindingIPImolecular_function
GO:2000872positive regulation of progesterone secretionIEAbiological_process
GO:0045893positive regulation of transcription, DNA-dependenIDAbiological_process
GO:0007417central nervous system developmentIEAbiological_process
GO:0005509calcium ion bindingIDAmolecular_function