Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:RTN4_HUMAN
Description:reticulon 4 [Source:HGNC Symbol;Acc:14085]
Location:chr2 p16.1
Node attribute:ligand

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S107PERQPsWDPSPPhosphoSitePlus; HPRD; phosphoELM
S654ETETFsDSSPIHPRD
S7LVSSHPRD; phosphoELM; SysPTM
S319VAAQDsETDYVHPRD
S418ESNLEsKVDKKPhosphoSitePlus
S778ETSFEsMIEYEPhosphoSitePlus
S181PKRRGsSGSVDPhosphoSitePlus; HPRD; phosphoELM
S114DPSPVsSTVPAPhosphoSitePlus
S946NGSATsKVLLLPhosphoSitePlus
S111PSWDPsPVSSTPhosphoSitePlus
S184RGSSGsVVVDLHPRD
T116SPVSStVPAPSPhosphoSitePlus
Y840LSTAVySNDDLPhosphoSitePlus
S920LPHDLsLKNIQPhosphoSitePlus
Y384PMREEyADFKPPhosphoSitePlus
S785EKEDRsPSAIFHPRD
S12SPLVSsSDSPPPhosphoSitePlus; HPRD
S182KRRGSsGSVDEPhosphoSitePlus; HPRD; phosphoELM
S737FSKNGsATSKVHPRD
Y782ESMIEyENKEKPhosphoSitePlus
T945KNGSAtSKVLLPhosphoSitePlus
S993EDRSPsAIFSAPhosphoSitePlus
S876FPTLIsSKTDSPhosphoSitePlus
S121TVPAPsPLSAAPhosphoSitePlus
S184RGSSGsVDETLPhosphoSitePlus; HPRD; phosphoELM
Y889KLAREyTDLEVPhosphoSitePlus
T450TSFPStPEGIKPhosphoSitePlus
S863TFSDSsPIEIIPhosphoSitePlus; HPRD
Y718PDFSDySEMAKPhosphoSitePlus
S15VSSSDsPPRPQPhosphoSitePlus; HPRD; phosphoELM; SysPTM
S515TSTKTsNPFLVHPRD
S657TFSDSsPIEIIHPRD
Y323DSETDyVTTDNHPRD
Y529DSETDyVTTDNHPRD
S991EKEDRsPSAIFPhosphoSitePlus; HPRD
S11QSPLVsSSDSPPhosphoSitePlus; HPRD
T188GSVDEtLFALPPhosphoSitePlus; HPRD; phosphoELM; SysPTM
S196ALPAAsEPVIRHPRD; SysPTM
S7EDLDQsPLVSSPhosphoSitePlus; SysPTM
T282SEKAKtLLIDRPhosphoSitePlus
S881SSKTDsFSKLAPhosphoSitePlus
Y25QPAFKyQFVREPhosphoSitePlus
S13PLVSSsDSPPRPhosphoSitePlus; HPRD
Y659ENPPPyEEAMSPhosphoSitePlus
Y646ASSVNyESIKHPhosphoSitePlus
S129SAAAVsPSKLPPhosphoSitePlus
S309TSTKTsNPFLVHPRD
S115PSPVSsTVPAPPhosphoSitePlus
S860ETETFsDSSPIHPRD
Y694ETEAPyISIACPhosphoSitePlus
S943FSKNGsATSKVPhosphoSitePlus; HPRD; SysPTM
S525VAAQDsETDYVHPRD

Dephosphorylation site
RTN4_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000378109L223VSjoblom2006Intestines Cancer16959974
ENSP00000349944S642CCOSMICOvarian Cancer21720365
ENSP00000337838L429VHPIColorectal Cancer16959974
ENSP00000385650S96*BIOMARTBreast Cancer21930507, 21930502
ENSP00000384471S96*BIOMARTBreast Cancer21930507, 21930502
ENSP00000349944S96*BIOMARTBreast Cancer21930507, 21930502
ENSP00000378109S96*BIOMARTBreast Cancer21930507, 21930502
ENSP00000337838S302*BIOMARTBreast Cancer21930507, 21930502
ENSP00000349944L223VCOSMICIntestines Cancer16959974

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000337838Breast CancerMetastasistissueUp18257521

Hyperphosphorylation site
RTN4_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
RTN4_HUMANRTN4R_HUMANligand -> receptorHPMR

Function Annotation
KEGG Pathway
RTN4_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0021801cerebral cortex radial glia guided migrationIEAbiological_process
GO:0021801cerebral cortex radial glia guided migrationISSbiological_process
GO:0048011nerve growth factor receptor signaling pathwayTASbiological_process
GO:0007399nervous system developmentIEAbiological_process
GO:0005635nuclear envelopeIDAcellular_component
GO:0030176integral to endoplasmic reticulum membraneIDAcellular_component
GO:0042995cell projectionIEAcellular_component
GO:0006915apoptotic processNASbiological_process
GO:0060317cardiac epithelial to mesenchymal transitionIEAbiological_process
GO:2000172regulation of branching morphogenesis of a nerveIEAbiological_process
GO:0050771negative regulation of axonogenesisTASbiological_process
GO:0030308negative regulation of cell growthIMPbiological_process
GO:0005886plasma membraneTAScellular_component
GO:0005515protein bindingIPImolecular_function
GO:0005515protein bindingIEAmolecular_function
GO:0043025neuronal cell bodyIEAcellular_component
GO:0005783endoplasmic reticulumIEAcellular_component
GO:0050770regulation of axonogenesisTASbiological_process
GO:0007413axonal fasciculationIEAbiological_process
GO:0030334regulation of cell migrationIDAbiological_process
GO:0001525angiogenesisIEAbiological_process
GO:0007413axonal fasciculationISSbiological_process
GO:0030517negative regulation of axon extensionIDAbiological_process
GO:2000172regulation of branching morphogenesis of a nerveISSbiological_process
GO:0042981regulation of apoptotic processNASbiological_process
GO:0005783endoplasmic reticulumNAScellular_component
GO:0051960regulation of nervous system developmentIEAbiological_process
GO:0071786endoplasmic reticulum tubular network organizationIMPbiological_process


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