| UniProt/SwissProt ID: | RRAS_HUMAN |
| Description: | related RAS viral (r-ras) oncogene homolog [Source:HGNC Symbol;Acc:10447] |
| Location: | chr19 q13.33 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| Y66 | TIEDSyTKICS | SRC | phosphoELM |
| T9 | GAASGtGRGRP | PhosphoSitePlus | |
| Y66 | TIEDSyTKICS | Src | RegPhos |
| Y66 | TIEDSyTKICS | Ras | PhosphoSitePlus |
| Y66 | TIEDSyTKICS | EPHB2 | HPRD |
| S201 | QELPPsPPSAP | PhosphoSitePlus; HPRD | |
| Y66 | TIEDSyTKICS | EphB2 | phosphoELM; RegPhos |
| Y58 | YFVSDyDPTIE | Ras | PhosphoSitePlus |
| Dephosphorylation site |
| RRAS_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000246792 | V216I | COSMIC | Ovarian Cancer | 20826764 | ENSP00000246792 | Y66* | COSMIC | Ovarian Cancer | 21720365 |
| Differential expressed protein |
| Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
|---|---|---|---|---|---|---|
| ENSP00000246792 | Hepatocellular Carcinoma | Normal vs. Cancer | cell line | Down | 0.49 | 18646787 | ENSP00000246792 | Hepatocellular Carcinoma | Normal vs. Cancer | cell line | Up | 5.5 | 18646787 | ENSP00000246792 | Prostate Cancer | Metastasis | tissue | Down | 0.31 | 18553995 | ENSP00000246792 | Testicular Cancer | Normal vs. Cancer | cell line | Up | 18489135 |
| Hyperphosphorylation site |
| RRAS_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| EPHB2_HUMAN | RRAS_HUMAN | kinase -> substrate | HPRD |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa05166 | HTLV-I infection |
| hsa04530 | Tight junction |
| hsa04010 | MAPK signaling pathway |
| hsa04810 | Regulation of actin cytoskeleton |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0006184 | GTP catabolic process | IEA | biological_process |
| GO:0007264 | small GTPase mediated signal transduction | IEA | biological_process |
| GO:0007265 | Ras protein signal transduction | TAS | biological_process |
| GO:0030336 | negative regulation of cell migration | IEA | biological_process |
| GO:0005622 | intracellular | IEA | cellular_component |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0006913 | nucleocytoplasmic transport | IEA | biological_process |
| GO:0019003 | GDP binding | IDA | molecular_function |
| GO:0007268 | synaptic transmission | TAS | biological_process |
| GO:0016020 | membrane | IEA | cellular_component |
| GO:0007165 | signal transduction | IEA | biological_process |
| GO:0005525 | GTP binding | IEA | molecular_function |
| GO:0005886 | plasma membrane | TAS | cellular_component |
| GO:0007411 | axon guidance | TAS | biological_process |
| GO:0045766 | positive regulation of angiogenesis | IMP | biological_process |
| GO:0006886 | intracellular protein transport | IEA | biological_process |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0003924 | GTPase activity | IDA | molecular_function |
| GO:0015031 | protein transport | IEA | biological_process |