| UniProt/SwissProt ID: | RPGP2_HUMAN |
| Description: | RAP1 GTPase activating protein 2 [Source:HGNC Symbol;Acc:29176] |
| Location: | chr17 p13.3 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S7 | FGRKRsVSFGG | PhosphoSitePlus | |
| S9 | RKRSVsFGGFG | PhosphoSitePlus; HPRD | |
| S665 | GGSQPsTTSPF | PhosphoSitePlus | |
| T510 | SHSMEtMVGGQ | PhosphoSitePlus | |
| S589 | CDSTSsTPKTP | PhosphoSitePlus | |
| T572 | FPRLHtGSEGQ | PhosphoSitePlus | |
| S45 | PDRPLsPPLTA | PhosphoSitePlus; HPRD | |
| S505 | AIRVRsHSMET | PhosphoSitePlus | |
| T593 | SSTPKtPDGGH | PhosphoSitePlus | |
| S588 | RCDSTsSTPKT | PhosphoSitePlus | |
| S507 | RVRSHsMETMV | PhosphoSitePlus | |
| S613 | SSNPSsPEICP | PhosphoSitePlus; HPRD; RegPhos | |
| S609 | KSETSsNPSSP | PhosphoSitePlus; HPRD | |
| S558 | KNQSRsPIKRR | PhosphoSitePlus | |
| S57 | PTMKSsEFFEM | PhosphoSitePlus | |
| T49 | LSPPLtAPPTM | PhosphoSitePlus; HPRD | |
| S586 | RARCDsTSSTP | PhosphoSitePlus | |
| S662 | GDSGGsQPSTT | PhosphoSitePlus | |
| T590 | DSTSStPKTPD | PhosphoSitePlus | |
| S564 | PIKRRsGLFPR | PhosphoSitePlus | |
| S612 | TSSNPsSPEIC | PhosphoSitePlus; HPRD | |
| T587 | ARCDStSSTPK | PhosphoSitePlus | |
| S7 | FGRKRsVSFGG | PKG1 | RegPhos |
| S496 | GGFLEsFKRAI | PhosphoSitePlus | |
| S574 | RLHTGsEGQGD | PhosphoSitePlus | |
| T667 | SQPSTtSPFKQ | PhosphoSitePlus | |
| S600 | DGGHSsQEIKS | PhosphoSitePlus | |
| S544 | TKTTFsPPVVA | PhosphoSitePlus; HPRD; RegPhos | |
| S605 | SQEIKsETSSN | PhosphoSitePlus | |
| S56 | PPTMKsSEFFE | PhosphoSitePlus | |
| S668 | QPSTTsPFKQE | PhosphoSitePlus | |
| Y88 | DDYIPyPSIDE | PhosphoSitePlus | |
| T53 | LTAPPtMKSSE | PhosphoSitePlus | |
| Y85 | KNKDDyIPYPS | PhosphoSitePlus | |
| Dephosphorylation site |
| RPGP2_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000254695 | P614L | COSMIC | Ovarian Cancer | 21720365 | ENSP00000254695 | D595G | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000389824 | P695A | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000389824 | M360R | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000254695 | M375R | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000254695 | P710A | BIOMART | Breast Cancer | 21930507, 21930502 |
| Differential expressed protein |
| RPGP2_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| RPGP2_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| ZAGL2_HUMAN | RPGP2_HUMAN | kinase -> substrate | RegPhos |
| Function Annotation |
| KEGG Pathway |
| RPGP2_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0005829 | cytosol | TAS | cellular_component |
| GO:0005813 | centrosome | IDA | cellular_component |
| GO:0005096 | GTPase activator activity | IEA | molecular_function |
| GO:0048471 | perinuclear region of cytoplasm | IEA | cellular_component |
| GO:0051056 | regulation of small GTPase mediated signal transdu | IEA | biological_process |