Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:RPGP1_HUMAN
Description:RAP1 GTPase activating protein [Source:HGNC Symbol;Acc:9858]
Location:chr1 p36.12
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S490PTRKKsGPFGSPKA_groupphosphoELM; RegPhos
S498FGSRRsSAIGIPhosphoSitePlus
S499GSRRSsAIGIEPhosphoSitePlus; phosphoELM
S437KRVIRsRSQSMPhosphoSitePlus
S499GSRRSsAIGIEPKACaRegPhos
S495SGPFGsRRSSAPhosphoSitePlus
S439VIRSRsQSMDAPhosphoSitePlus
S484IVPGKsPTRKKCDC2RegPhos
S490PTRKKsGPFGSPhosphoSitePlus
S484IVPGKsPTRKKCDC2(CDK1RegPhos
T547SPEMPtTKNRAPhosphoSitePlus
S441RSRSQsMDAMGPhosphoSitePlus
S499GSRRSsAIGIEPRKACAHPRD
S525QKTPDsGHVSQGSK3B(GSK3 betaRegPhos
S484IVPGKsPTRKKPhosphoSitePlus; phosphoELM
S499GSRRSsAIGIEPKA_groupphosphoELM; RegPhos
S490PTRKKsGPFGSPKACaRegPhos
S484IVPGKsPTRKKCDK1HPRD; phosphoELM
S515QEKREsPPAGQPhosphoSitePlus
T548PEMPTtKNRAEPhosphoSitePlus
S525QKTPDsGHVSQPhosphoSitePlus
S525QKTPDsGHVSQGSK-3_betaphosphoELM
S490PTRKKsGPFGSPRKACAHPRD
Y27KTEEDyIPYPSPhosphoSitePlus
T486PGKSPtRKKSGHPRD; phosphoELM

Dephosphorylation site
RPGP1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000363897Y609CBIOMART, HPIBreast Cancer21930507, 21930502, 16959974 20124489
ENSP00000363897C257RBIOMART, HPIBreast Cancer21930507, 21930502, 16959974

Differential expressed protein
RPGP1_HUMAN is not differential expressed protein.

Hyperphosphorylation site
RPGP1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
GSK3B_HUMANRPGP1_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
KPCA_HUMANRPGP1_HUMANkinase -> substrateHPRD
CDK1_HUMANRPGP1_HUMANkinase -> substrateHPRD; RegPhos

Function Annotation
KEGG Pathway
RPGP1_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0051056regulation of small GTPase mediated signal transduIEAbiological_process
GO:0007165signal transductionIEAbiological_process
GO:0000139Golgi membraneIEAcellular_component
GO:0006184GTP catabolic processNASbiological_process
GO:0003924GTPase activityNASmolecular_function
GO:0016020membraneIDAcellular_component
GO:0042803protein homodimerization activityIPImolecular_function
GO:0005829cytosolIDAcellular_component
GO:0017016Ras GTPase bindingIPImolecular_function
GO:0032318regulation of Ras GTPase activityIDAbiological_process
GO:0030695GTPase regulator activityIEAmolecular_function
GO:0043547positive regulation of GTPase activityTASbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0005096GTPase activator activityIEAmolecular_function


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