| UniProt/SwissProt ID: | RON_HUMAN |
| Description: | macrophage stimulating 1 receptor (c-met-related tyrosine kinase) [Source:HGNC Symbol;Acc:7381] |
| Location: | chr3 p21.31 |
| Node attribute: | kinase; receptor; substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| Y1360 | QLPATyMNLGP | autocatalysis | RegPhos |
| S215 | SFSPRsVSIRR | Sema | PhosphoSitePlus |
| Y1017 | YSGSDyRSGLA | PhosphoSitePlus | |
| Y1239 | LDREYySVQQH | Ron | RegPhos |
| S1394 | RPRPLsEPPR | phosphoELM | |
| Y1238 | ILDREyYSVQQ | RON | phosphoELM; RegPhos |
| Y1101 | VYHGEyIDQAQ | Pkinase_Tyr | PhosphoSitePlus |
| S226 | LKADAsGFAPG | Sema | PhosphoSitePlus |
| Y1237 | DILDReYYSVQ | HPRD | |
| Y1239 | LDREYySVQQH | RON | phosphoELM; RegPhos |
| Y1239 | LDREYySVQQH | Pkinase_Tyr | PhosphoSitePlus |
| Y1360 | QLPATyMNLGP | MST1R | HPRD |
| S1394 | RPRPLsEPPRP | PhosphoSitePlus | |
| Y1239 | LDREYySVQQH | MST1R | HPRD |
| Y1317 | CPDSLyQVMQQ | Pkinase_Tyr | PhosphoSitePlus |
| Y1353 | LLGDHyVQLPA | PhosphoSitePlus | |
| Y1238 | ILDREyYSVQQ | MST1R | HPRD |
| Y1353 | LLGDHyVQLPA | MST1R | HPRD |
| S1240 | DREYYsVQQHR | Pkinase_Tyr | PhosphoSitePlus |
| Y1360 | QLPATyMNLGP | RON | phosphoELM; RegPhos |
| Y1360 | QLPATyMNLGP | PhosphoSitePlus | |
| Y1353 | LLGDHyVQLPA | RON | phosphoELM; RegPhos |
| Y1360 | QLPATyMNLGP | Ron | RegPhos |
| S1394 | RPRPLsEPPRP | AKT_group | RegPhos |
| S236 | GFVALsVLPKH | Sema | PhosphoSitePlus |
| Y1238 | ILDREyYSVQQ | Pkinase_Tyr | PhosphoSitePlus |
| Y1353 | LLGDHyVQLPA | autocatalysis | RegPhos |
| Y1353 | LLGDHyVQLPA | Ron | RegPhos |
| S1394 | RPRPLsEPPR | PKB_group | phosphoELM |
| Y1238 | ILDREyYSVQQ | Ron | RegPhos |
| Dephosphorylation site |
| RON_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000296474 | F401L | COSMIC | Ovarian Cancer | 21720365 | ENSP00000296474 | R1130* | Ding2008, BIOMART | Lung Cancer | 18948947, 21930507, 21930502 | ENSP00000296474 | K1114* | COSMIC | Lung Cancer | 20668451 | ENSP00000296474 | D892N | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000296474 | T1400S | COSMIC | Skin Cancer | 21984974 | ENSP00000296474 | E1154K | BIOMART | Pancreatic Cancer | 21930507, 21930502 | ENSP00000296474 | V772L | COSMIC | Lung Cancer | 20668451 | ENSP00000341325 | E1105K | BIOMART | Pancreatic Cancer | 21930507, 21930502 |
| Differential expressed protein |
| RON_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| RON_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| STK4_HUMAN | RON_HUMAN | ligand -> receptor | HPMR |
| RON_HUMAN | RON_HUMAN | kinase -> substrate | RegPhos |
| AKT1_HUMAN | RON_HUMAN | kinase -> substrate | NetPath |
| Function Annotation |
| KEGG Pathway |
| RON_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0007169 | transmembrane receptor protein tyrosine kinase sig | IEA | biological_process |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0016020 | membrane | IEA | cellular_component |
| GO:0009615 | response to virus | IDA | biological_process |
| GO:0019899 | enzyme binding | IPI | molecular_function |
| GO:0016772 | transferase activity, transferring phosphorus-cont | IEA | molecular_function |
| GO:0004872 | receptor activity | IEA | molecular_function |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0005011 | macrophage colony-stimulating factor receptor acti | TAS | molecular_function |
| GO:0006952 | defense response | TAS | biological_process |
| GO:0016021 | integral to membrane | IEA | cellular_component |
| GO:0001725 | stress fiber | IEA | cellular_component |
| GO:0004713 | protein tyrosine kinase activity | IEA | molecular_function |
| GO:0004672 | protein kinase activity | IEA | molecular_function |
| GO:0007165 | signal transduction | TAS | biological_process |
| GO:0005886 | plasma membrane | IEA | cellular_component |
| GO:0004714 | transmembrane receptor protein tyrosine kinase act | IEA | molecular_function |
| GO:0006468 | protein phosphorylation | IEA | biological_process |
| GO:0008284 | positive regulation of cell proliferation | TAS | biological_process |
| GO:0038145 | macrophage colony-stimulating factor signaling pat | TAS | biological_process |
| GO:0051897 | positive regulation of protein kinase B signaling | IDA | biological_process |
| GO:0007338 | single fertilization | TAS | biological_process |
| GO:0045087 | innate immune response | IEA | biological_process |
| GO:0043406 | positive regulation of MAP kinase activity | IDA | biological_process |
| GO:0009615 | response to virus | IEA | biological_process |
| GO:0005887 | integral to plasma membrane | TAS | cellular_component |
| GO:0007275 | multicellular organismal development | IEA | biological_process |
| GO:0006928 | cellular component movement | TAS | biological_process |