| UniProt/SwissProt ID: | ROA1_HUMAN |
| Description: | heterogeneous nuclear ribonucleoprotein A1 [Source:HGNC Symbol;Acc:5031] |
| Location: | chr12 q13.13 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S338 | FGGRSsGPYGG | PhosphoSitePlus; HPRD; phosphoELM; RegPhos | |
| S190 | EMASAsSSQRG | NID | PhosphoSitePlus |
| S4 | __MSKsESPKE | PhosphoSitePlus; SysPTM | |
| Y366 | SSSSSyGSGRR | PhosphoSitePlus | |
| S360 | GGYGGsSSSSS | PhosphoSitePlus; HPRD | |
| S22 | FIGGLsFETTD | RRM_1 | PhosphoSitePlus |
| S361 | GYGGSsSSSSY | PhosphoSitePlus; HPRD | |
| Y253 | GNDGGyGGGGP | PhosphoSitePlus | |
| S364 | GSSSSsSYGSG | PhosphoSitePlus; HPRD; phosphoELM; RegPhos | |
| S142 | MTDRGsGKKRG | RRM_1 | PhosphoSitePlus |
| Y347 | GGGGQyFAKPR | PhosphoSitePlus; HPRD; phosphoELM; RegPhos | |
| S95 | VSREDsQRPGA | PhosphoSitePlus; HPRD; phosphoELM; RegPhos | |
| S199 | RGRSGsGNFGG | PKA_group | phosphoELM; RegPhos |
| S192 | ASASSsQRGRS | NID | PhosphoSitePlus |
| S91 | PKRAVsREDSQ | PhosphoSitePlus; HPRD; phosphoELM; RegPhos | |
| Y244 | GSGDGyNGFGN | PhosphoSitePlus | |
| S199 | RGRSGsGNFGG | CK2a1(CK2 alpha | RegPhos |
| Y357 | RNQGGyGGSSS | PhosphoSitePlus; HPRD | |
| S6 | KEPE | HPRD; phosphoELM; SysPTM | |
| Y167 | IVIQKyHTVNG | RRM_1; NID | PhosphoSitePlus |
| S6 | MSKSEsPKEPE | PhosphoSitePlus; RegPhos; SysPTM | |
| S199 | RGRSGsGNFGG | PhosphoSitePlus | |
| S2 | MSKSEsP | RegPhos | |
| T138 | VIEIMtDRGSG | RRM_1 | PhosphoSitePlus |
| Y341 | RSSGPyGGGGQ | PhosphoSitePlus | |
| S4 | MSKSEsPKE | RegPhos; SysPTM | |
| S311 | FGGGGsYNDFG | RegPhos | |
| S362 | YGGSSsSSSYG | PhosphoSitePlus; HPRD; phosphoELM; RegPhos | |
| T169 | IQKYHtVNGHN | RRM_1; NID | PhosphoSitePlus |
| S142 | MTDRGsGKKRG | HPRD; phosphoELM | |
| S365 | SSSSSsYGSGR | PhosphoSitePlus; HPRD; SysPTM | |
| S29 | ETTDEsLRSHF | RRM_1 | PhosphoSitePlus |
| S191 | MASASsSQRGR | NID | PhosphoSitePlus |
| Y167 | IVIQKyHTVNG | HPRD; phosphoELM; RegPhos | |
| S2 | SESP | HPRD; phosphoELM | |
| S363 | GGSSSsSSYGS | PhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM | |
| S199 | RGRSGsGNFGG | CK2_alpha | phosphoELM |
| T61 | GFGFVtYATVE | RRM_1 | PhosphoSitePlus |
| S368 | SSSYGsGR | HPRD; phosphoELM; SysPTM | |
| S192 | ASASSsQRGRS | phosphoELM; RegPhos | |
| Y318 | NDFGNyNNQSS | PhosphoSitePlus | |
| T138 | VIEIMtDRGSG | HPRD; phosphoELM; RegPhos | |
| S197 | SQRGRsGSGNF | PhosphoSitePlus | |
| S2 | ____MsKSESP | PhosphoSitePlus | |
| S4 | SPKE | HPRD; phosphoELM; SysPTM | |
| Y312 | GGGGSyNDFGN | PhosphoSitePlus | |
| S368 | SSSYGsGRRF_ | PhosphoSitePlus; SysPTM | |
| S337 | NFGGRsSGPYG | PhosphoSitePlus; HPRD; phosphoELM | |
| Dephosphorylation site |
| ROA1_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000448617 | E28K | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000449913 | E28K | TCGA | Ovarian Cancer | 21720365, 18772890 |
| Differential expressed protein |
| ROA1_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| ROA1_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| CSK21_HUMAN | ROA1_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| ZAGL2_HUMAN | ROA1_HUMAN | kinase -> substrate | RegPhos |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa03040 | Spliceosome |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0006405 | RNA export from nucleus | IC | biological_process |
| GO:0005634 | nucleus | IDA | cellular_component |
| GO:0003723 | RNA binding | TAS | molecular_function |
| GO:0051028 | mRNA transport | IEA | biological_process |
| GO:0071013 | catalytic step 2 spliceosome | IDA | cellular_component |
| GO:0051170 | nuclear import | IDA | biological_process |
| GO:0005654 | nucleoplasm | IDA | cellular_component |
| GO:0006397 | mRNA processing | TAS | biological_process |
| GO:0045111 | intermediate filament cytoskeleton | IDA | cellular_component |
| GO:0008380 | RNA splicing | TAS | biological_process |
| GO:0030529 | ribonucleoprotein complex | IDA | cellular_component |
| GO:0003697 | single-stranded DNA binding | IDA | molecular_function |
| GO:0003676 | nucleic acid binding | IEA | molecular_function |
| GO:0005737 | cytoplasm | IDA | cellular_component |
| GO:0000398 | mRNA splicing, via spliceosome | IC | biological_process |
| GO:0051168 | nuclear export | IDA | biological_process |
| GO:0003727 | single-stranded RNA binding | IC | molecular_function |
| GO:0005730 | nucleolus | IDA | cellular_component |
| GO:0000166 | nucleotide binding | IEA | molecular_function |
| GO:0010467 | gene expression | TAS | biological_process |
| GO:0019048 | virus-host interaction | IEA | biological_process |
| GO:0005681 | spliceosomal complex | IDA | cellular_component |