Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:ROA1_HUMAN
Description:heterogeneous nuclear ribonucleoprotein A1 [Source:HGNC Symbol;Acc:5031]
Location:chr12 q13.13
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S338FGGRSsGPYGGPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S190EMASAsSSQRGNIDPhosphoSitePlus
S4__MSKsESPKEPhosphoSitePlus; SysPTM
Y366SSSSSyGSGRRPhosphoSitePlus
S360GGYGGsSSSSSPhosphoSitePlus; HPRD
S22FIGGLsFETTDRRM_1PhosphoSitePlus
S361GYGGSsSSSSYPhosphoSitePlus; HPRD
Y253GNDGGyGGGGPPhosphoSitePlus
S364GSSSSsSYGSGPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S142MTDRGsGKKRGRRM_1PhosphoSitePlus
Y347GGGGQyFAKPRPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S95VSREDsQRPGAPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S199RGRSGsGNFGGPKA_groupphosphoELM; RegPhos
S192ASASSsQRGRSNIDPhosphoSitePlus
S91PKRAVsREDSQPhosphoSitePlus; HPRD; phosphoELM; RegPhos
Y244GSGDGyNGFGNPhosphoSitePlus
S199RGRSGsGNFGGCK2a1(CK2 alphaRegPhos
Y357RNQGGyGGSSSPhosphoSitePlus; HPRD
S6KEPEHPRD; phosphoELM; SysPTM
Y167IVIQKyHTVNGRRM_1; NIDPhosphoSitePlus
S6MSKSEsPKEPEPhosphoSitePlus; RegPhos; SysPTM
S199RGRSGsGNFGGPhosphoSitePlus
S2MSKSEsPRegPhos
T138VIEIMtDRGSGRRM_1PhosphoSitePlus
Y341RSSGPyGGGGQPhosphoSitePlus
S4MSKSEsPKERegPhos; SysPTM
S311FGGGGsYNDFGRegPhos
S362YGGSSsSSSYGPhosphoSitePlus; HPRD; phosphoELM; RegPhos
T169IQKYHtVNGHNRRM_1; NIDPhosphoSitePlus
S142MTDRGsGKKRGHPRD; phosphoELM
S365SSSSSsYGSGRPhosphoSitePlus; HPRD; SysPTM
S29ETTDEsLRSHFRRM_1PhosphoSitePlus
S191MASASsSQRGRNIDPhosphoSitePlus
Y167IVIQKyHTVNGHPRD; phosphoELM; RegPhos
S2SESPHPRD; phosphoELM
S363GGSSSsSSYGSPhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM
S199RGRSGsGNFGGCK2_alphaphosphoELM
T61GFGFVtYATVERRM_1PhosphoSitePlus
S368SSSYGsGRHPRD; phosphoELM; SysPTM
S192ASASSsQRGRSphosphoELM; RegPhos
Y318NDFGNyNNQSSPhosphoSitePlus
T138VIEIMtDRGSGHPRD; phosphoELM; RegPhos
S197SQRGRsGSGNFPhosphoSitePlus
S2____MsKSESPPhosphoSitePlus
S4SPKEHPRD; phosphoELM; SysPTM
Y312GGGGSyNDFGNPhosphoSitePlus
S368SSSYGsGRRF_PhosphoSitePlus; SysPTM
S337NFGGRsSGPYGPhosphoSitePlus; HPRD; phosphoELM

Dephosphorylation site
ROA1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000448617E28KTCGAOvarian Cancer21720365, 18772890
ENSP00000449913E28KTCGAOvarian Cancer21720365, 18772890

Differential expressed protein
ROA1_HUMAN is not differential expressed protein.

Hyperphosphorylation site
ROA1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
CSK21_HUMANROA1_HUMANkinase -> substrateRobert H Newman (2013)
ZAGL2_HUMANROA1_HUMANkinase -> substrateRegPhos

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa03040Spliceosome

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0006405RNA export from nucleusICbiological_process
GO:0005634nucleusIDAcellular_component
GO:0003723RNA bindingTASmolecular_function
GO:0051028mRNA transportIEAbiological_process
GO:0071013catalytic step 2 spliceosomeIDAcellular_component
GO:0051170nuclear importIDAbiological_process
GO:0005654nucleoplasmIDAcellular_component
GO:0006397mRNA processingTASbiological_process
GO:0045111intermediate filament cytoskeletonIDAcellular_component
GO:0008380RNA splicingTASbiological_process
GO:0030529ribonucleoprotein complexIDAcellular_component
GO:0003697single-stranded DNA bindingIDAmolecular_function
GO:0003676nucleic acid bindingIEAmolecular_function
GO:0005737cytoplasmIDAcellular_component
GO:0000398mRNA splicing, via spliceosomeICbiological_process
GO:0051168nuclear exportIDAbiological_process
GO:0003727single-stranded RNA bindingICmolecular_function
GO:0005730nucleolusIDAcellular_component
GO:0000166nucleotide bindingIEAmolecular_function
GO:0010467gene expressionTASbiological_process
GO:0019048virus-host interactionIEAbiological_process
GO:0005681spliceosomal complexIDAcellular_component


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