Phosphorylation

Protein information

UniProt/SwissProt ID:	RO52_HUMAN
Description:	tripartite motif containing 21 [Source:HGNC Symbol;Acc:11312]
Location:	chr11 p15.4
Node attribute:	substrate

Position	PhosphoPeptide	Catalytic kinase	Source
S266	DLDITsPELRS		PhosphoSitePlus; HPRD; phosphoELM; SysPTM
S469	PLNIGsQGSTD		PhosphoSitePlus
S447	LRPFFsPGFND	SPRY	PhosphoSitePlus
Y393	YEAGTyPQTPL	SPRY	PhosphoSitePlus

RO52_HUMAN do not have dephosphorylation site.

Ensembl ID	Variation	Source	Cancer name	Pubmed
ENSP00000254436	E192Q	COSMIC	Ovarian Cancer	21720365
ENSP00000254436	V250L	COSMIC	Ovarian Cancer	21720365
ENSP00000254436	A437T	COSMIC	Ovarian Cancer	21720365

RO52_HUMAN is not differential expressed protein.

RO52_HUMAN do not have hyperphosphorylation site.

Source	Target	Relationship	Resource
MP2K7_HUMAN	RO52_HUMAN	kinase -> substrate	Robert H Newman (2013)

KEGG Pathway

RO52_HUMAN is not in KEGG pathway.

Gene Ontology

GO ID	GO_Term	Evidence	Ontology
GO:0070206	protein trimerization	IDA	biological_process
GO:0051865	protein autoubiquitination	IDA	biological_process
GO:0000209	protein polyubiquitination	IDA	biological_process
GO:0005622	intracellular	IEA	cellular_component
GO:0019005	SCF ubiquitin ligase complex	IDA	cellular_component
GO:0000932	cytoplasmic mRNA processing body	IEA	cellular_component
GO:0005515	protein binding	IPI	molecular_function
GO:0003677	DNA binding	IEA	molecular_function
GO:0005737	cytoplasm	IDA	cellular_component
GO:0003723	RNA binding	IEA	molecular_function
GO:0000151	ubiquitin ligase complex	IEA	cellular_component
GO:0030529	ribonucleoprotein complex	TAS	cellular_component
GO:0005737	cytoplasm	IEA	cellular_component
GO:0006513	protein monoubiquitination	IDA	biological_process
GO:0008270	zinc ion binding	IEA	molecular_function
GO:0016567	protein ubiquitination	IDA	biological_process
GO:0004842	ubiquitin-protein ligase activity	IDA	molecular_function
GO:0005634	nucleus	IDA	cellular_component
GO:0007049	cell cycle	IEA	biological_process
GO:0090086	negative regulation of protein deubiquitination	IMP	biological_process
GO:0031648	protein destabilization	IMP	biological_process
GO:0045787	positive regulation of cell cycle	IMP	biological_process
GO:0032088	negative regulation of NF-kappaB transcription fac	IDA	biological_process

Human Phosphorylation Mediated
Signaling Transduction Network