Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:RIR2_HUMAN
Description:ribonucleotide reductase M2 [Source:HGNC Symbol;Acc:10452]
Location:chr2 p25.1
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T12PLAPItDPQQLPhosphoSitePlus
S20QQLQLsPLKGLCDC2(CDK1RegPhos; SysPTM
S20QQLQLsPLKGLCDK1HPRD; phosphoELM; SysPTM
T40PALSGtRVLASPhosphoSitePlus
T318IGMNCtLMKQYRibonuc_red_smPhosphoSitePlus
S45TRVLAsKTARRPhosphoSitePlus
S20QQLQLsPLKGLPhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM
S26PLKGLsLVDKEPhosphoSitePlus
S38TPPALsGTRVLPhosphoSitePlus
S263SNELIsRDEGLRibonuc_red_smPhosphoSitePlus
S377MGVMSsPTENSPhosphoSitePlus
S20QQLQLsPLKGLCDC2RegPhos; SysPTM
Y221DKEATyGERVVRibonuc_red_smPhosphoSitePlus
T33VDKENtPPALSPhosphoSitePlus; HPRD; phosphoELM
Y369KRVGEyQRMGVPhosphoSitePlus
T47VLASKtARRIFPhosphoSitePlus

Dephosphorylation site
RIR2_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000302955D138HBIOMARTBreast Cancer21930507, 21930502
ENSP00000302955I324TBIOMARTBreast Cancer21930507, 21930502

Differential expressed protein
RIR2_HUMAN is not differential expressed protein.

Hyperphosphorylation site
RIR2_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
CDK1_HUMANRIR2_HUMANkinase -> substrateHPRD; RegPhos
ZAGL2_HUMANRIR2_HUMANkinase -> substrateRegPhos

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa00240Pyrimidine metabolism
hsa00480Glutathione metabolism
hsa01100Metabolic pathways
hsa04115p53 signaling pathway
hsa00230Purine metabolism

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0000083regulation of transcription involved in G1/S phaseTASbiological_process
GO:0005654nucleoplasmTAScellular_component
GO:0051259protein oligomerizationIEAbiological_process
GO:0055114oxidation-reduction processIEAbiological_process
GO:0044281small molecule metabolic processTASbiological_process
GO:0009263deoxyribonucleotide biosynthetic processIEAbiological_process
GO:0016491oxidoreductase activityIEAmolecular_function
GO:0005829cytosolTAScellular_component
GO:0005515protein bindingIPImolecular_function
GO:0004748ribonucleoside-diphosphate reductase activity, thiISSmolecular_function
GO:0005515protein bindingIEAmolecular_function
GO:0000082G1/S transition of mitotic cell cycleTASbiological_process
GO:0009262deoxyribonucleotide metabolic processIEAbiological_process
GO:0055086nucleobase-containing small molecule metabolic proTASbiological_process
GO:0051290protein heterotetramerizationIEAbiological_process
GO:0009186deoxyribonucleoside diphosphate metabolic processIEAbiological_process
GO:0046914transition metal ion bindingIEAmolecular_function
GO:0005971ribonucleoside-diphosphate reductase complexIEAcellular_component
GO:0000278mitotic cell cycleTASbiological_process
GO:0015949nucleobase-containing small molecule interconversiTASbiological_process
GO:0004748ribonucleoside-diphosphate reductase activity, thiIEAmolecular_function
GO:0005737cytoplasmNAScellular_component
GO:0009263deoxyribonucleotide biosynthetic processISSbiological_process
GO:0006260DNA replicationNASbiological_process


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