| UniProt/SwissProt ID: | RHG07_HUMAN |
| Description: | deleted in liver cancer 1 [Source:HGNC Symbol;Acc:2897] |
| Location: | chr8 p22 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| T312 | SSQSEtSSAVS | RegPhos | |
| S995 | ASLTRsNRHRL | PhosphoSitePlus | |
| S549 | PERRDsGVGAS | HPRD | |
| S89 | KRSDDsDEDEP | RegPhos | |
| S354 | RARLDsMVLLI | PhosphoSitePlus | |
| S1209 | LLYFLsDVTAA | RhoGAP | PhosphoSitePlus |
| S1244 | LKRENsSPRVM | PhosphoSitePlus | |
| S593 | RQEVSsVRSLS | PhosphoSitePlus | |
| S313 | SQSETsSAVST | RegPhos | |
| S850 | GPGHIsLRREN | PhosphoSitePlus | |
| S1004 | RLRWHsFQSSH | AKT1 | HPRD |
| T318 | SSAVStPSPVT | RegPhos | |
| S567 | RLRWHsFQSSH | AKT1 | HPRD; RegPhos |
| S327 | VTRTRsLSACN | AKT1 | HPRD; RegPhos |
| S743 | TQTSSsSSQSE | PhosphoSitePlus | |
| S986 | PERRDsGVGAS | PhosphoSitePlus; HPRD | |
| S750 | SQSETsSAVST | PhosphoSitePlus | |
| S766 | RTRSLsACNKR | AKT1 | HPRD |
| S305 | STQTSsSSSQS | RegPhos | |
| S317 | TSSAVsTPSPV | RegPhos | |
| S1355 | EQAELsYKKVS | START | PhosphoSitePlus |
| S733 | MVRKRsVSNST | PhosphoSitePlus | |
| S329 | RTRSLsACNKR | AKT1 | HPRD; RegPhos |
| S592 | ERQEVsSVRSL | PhosphoSitePlus | |
| T600 | RSLSStGSLPS | PhosphoSitePlus | |
| S304 | NSTQTsSSSSQ | RegPhos | |
| S757 | AVSTPsPVTRT | PhosphoSitePlus | |
| S86 | PHRKRsDDSDE | RegPhos | |
| T755 | SSAVStPSPVT | PhosphoSitePlus | |
| T993 | VGASLtRSNRH | PhosphoSitePlus | |
| S310 | SSSSQsETSSA | RegPhos | |
| S764 | VTRTRsLSACN | AKT1 | HPRD |
| Dephosphorylation site |
| RHG07_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000276297 | S1527F | COSMIC | Skin Cancer | 21984974 | ENSP00000276297 | N797Y | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000351797 | R857H | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000276297 | R958* | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000276297 | T823I | COSMIC | Skin Cancer | 21984974 | ENSP00000276297 | R1294H | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000276297 | R347* | COSMIC | Renal Cancer | 20054297 | ENSP00000276297 | K237N | COSMIC | Lung Cancer | ENSP00000276297 | R1294C | COSMIC | Ovarian Cancer | 21720365 | ENSP00000351797 | E362K | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000321034 | S156I | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000276297 | E898* | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000321034 | Q485* | COSMIC | Skin Cancer | 21984974 | ENSP00000321034 | P484L | COSMIC | Melanoma | 21499247 | ENSP00000321034 | A450V | COSMIC | Pancreatic Cancer | ENSP00000276297 | S156I | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000276297 | E799K | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000276297 | R1425Q | COSMIC | Pancreatic Cancer |
| Differential expressed protein |
| RHG07_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| RHG07_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| AKT1_HUMAN | RHG07_HUMAN | kinase -> substrate | RegPhos |
| ZAGL2_HUMAN | RHG07_HUMAN | kinase -> substrate | RegPhos |
| Function Annotation |
| KEGG Pathway |
| RHG07_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0005829 | cytosol | TAS | cellular_component |
| GO:0032321 | positive regulation of Rho GTPase activity | IMP | biological_process |
| GO:0035024 | negative regulation of Rho protein signal transduc | IMP | biological_process |
| GO:0005901 | caveola | IDA | cellular_component |
| GO:0005622 | intracellular | IEA | cellular_component |
| GO:0030900 | forebrain development | ISS | biological_process |
| GO:0051497 | negative regulation of stress fiber assembly | IDA | biological_process |
| GO:0021575 | hindbrain morphogenesis | IEA | biological_process |
| GO:0001843 | neural tube closure | IEA | biological_process |
| GO:0007264 | small GTPase mediated signal transduction | TAS | biological_process |
| GO:0030900 | forebrain development | IEA | biological_process |
| GO:0051056 | regulation of small GTPase mediated signal transdu | TAS | biological_process |
| GO:0006917 | induction of apoptosis | IDA | biological_process |
| GO:0001843 | neural tube closure | ISS | biological_process |
| GO:0030036 | actin cytoskeleton organization | IEA | biological_process |
| GO:0008285 | negative regulation of cell proliferation | IDA | biological_process |
| GO:0030036 | actin cytoskeleton organization | ISS | biological_process |
| GO:0032956 | regulation of actin cytoskeleton organization | IMP | biological_process |
| GO:0005100 | Rho GTPase activator activity | IMP | molecular_function |
| GO:0005925 | focal adhesion | IDA | cellular_component |
| GO:0003007 | heart morphogenesis | IEA | biological_process |
| GO:0035307 | positive regulation of protein dephosphorylation | IDA | biological_process |
| GO:0003007 | heart morphogenesis | ISS | biological_process |
| GO:0030336 | negative regulation of cell migration | IMP | biological_process |
| GO:0006919 | activation of cysteine-type endopeptidase activity | IDA | biological_process |
| GO:0008360 | regulation of cell shape | IMP | biological_process |
| GO:0048041 | focal adhesion assembly | IEA | biological_process |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0005737 | cytoplasm | IDA | cellular_component |
| GO:0042169 | SH2 domain binding | IPI | molecular_function |
| GO:0048041 | focal adhesion assembly | ISS | biological_process |
| GO:0005634 | nucleus | IDA | cellular_component |
| GO:0021575 | hindbrain morphogenesis | ISS | biological_process |
| GO:0007165 | signal transduction | IEA | biological_process |