Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:RHG07_HUMAN
Description:deleted in liver cancer 1 [Source:HGNC Symbol;Acc:2897]
Location:chr8 p22
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T312SSQSEtSSAVSRegPhos
S995ASLTRsNRHRLPhosphoSitePlus
S549PERRDsGVGASHPRD
S89KRSDDsDEDEPRegPhos
S354RARLDsMVLLIPhosphoSitePlus
S1209LLYFLsDVTAARhoGAPPhosphoSitePlus
S1244LKRENsSPRVMPhosphoSitePlus
S593RQEVSsVRSLSPhosphoSitePlus
S313SQSETsSAVSTRegPhos
S850GPGHIsLRRENPhosphoSitePlus
S1004RLRWHsFQSSHAKT1HPRD
T318SSAVStPSPVTRegPhos
S567RLRWHsFQSSHAKT1HPRD; RegPhos
S327VTRTRsLSACNAKT1HPRD; RegPhos
S743TQTSSsSSQSEPhosphoSitePlus
S986PERRDsGVGASPhosphoSitePlus; HPRD
S750SQSETsSAVSTPhosphoSitePlus
S766RTRSLsACNKRAKT1HPRD
S305STQTSsSSSQSRegPhos
S317TSSAVsTPSPVRegPhos
S1355EQAELsYKKVSSTARTPhosphoSitePlus
S733MVRKRsVSNSTPhosphoSitePlus
S329RTRSLsACNKRAKT1HPRD; RegPhos
S592ERQEVsSVRSLPhosphoSitePlus
T600RSLSStGSLPSPhosphoSitePlus
S304NSTQTsSSSSQRegPhos
S757AVSTPsPVTRTPhosphoSitePlus
S86PHRKRsDDSDERegPhos
T755SSAVStPSPVTPhosphoSitePlus
T993VGASLtRSNRHPhosphoSitePlus
S310SSSSQsETSSARegPhos
S764VTRTRsLSACNAKT1HPRD

Dephosphorylation site
RHG07_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000276297S1527FCOSMICSkin Cancer21984974
ENSP00000276297N797YCOSMICHead and Neck Cancer21798893
ENSP00000351797R857HBIOMARTBreast Cancer21930507, 21930502
ENSP00000276297R958*COSMICHead and Neck Cancer21798893
ENSP00000276297T823ICOSMICSkin Cancer21984974
ENSP00000276297R1294HBIOMARTBreast Cancer21930507, 21930502
ENSP00000276297R347*COSMICRenal Cancer20054297
ENSP00000276297K237NCOSMICLung Cancer
ENSP00000276297R1294CCOSMICOvarian Cancer21720365
ENSP00000351797E362KBIOMARTBreast Cancer21930507, 21930502
ENSP00000321034S156ICOSMICHead and Neck Cancer21798893
ENSP00000276297E898*COSMICHead and Neck Cancer21798893
ENSP00000321034Q485*COSMICSkin Cancer21984974
ENSP00000321034P484LCOSMICMelanoma21499247
ENSP00000321034A450VCOSMICPancreatic Cancer
ENSP00000276297S156ICOSMICHead and Neck Cancer21798893
ENSP00000276297E799KBIOMARTBreast Cancer21930507, 21930502
ENSP00000276297R1425QCOSMICPancreatic Cancer

Differential expressed protein
RHG07_HUMAN is not differential expressed protein.

Hyperphosphorylation site
RHG07_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
AKT1_HUMANRHG07_HUMANkinase -> substrateRegPhos
ZAGL2_HUMANRHG07_HUMANkinase -> substrateRegPhos

Function Annotation
KEGG Pathway
RHG07_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005829cytosolTAScellular_component
GO:0032321positive regulation of Rho GTPase activityIMPbiological_process
GO:0035024negative regulation of Rho protein signal transducIMPbiological_process
GO:0005901caveolaIDAcellular_component
GO:0005622intracellularIEAcellular_component
GO:0030900forebrain developmentISSbiological_process
GO:0051497negative regulation of stress fiber assemblyIDAbiological_process
GO:0021575hindbrain morphogenesisIEAbiological_process
GO:0001843neural tube closureIEAbiological_process
GO:0007264small GTPase mediated signal transductionTASbiological_process
GO:0030900forebrain developmentIEAbiological_process
GO:0051056regulation of small GTPase mediated signal transduTASbiological_process
GO:0006917induction of apoptosisIDAbiological_process
GO:0001843neural tube closureISSbiological_process
GO:0030036actin cytoskeleton organizationIEAbiological_process
GO:0008285negative regulation of cell proliferationIDAbiological_process
GO:0030036actin cytoskeleton organizationISSbiological_process
GO:0032956regulation of actin cytoskeleton organizationIMPbiological_process
GO:0005100Rho GTPase activator activityIMPmolecular_function
GO:0005925focal adhesionIDAcellular_component
GO:0003007heart morphogenesisIEAbiological_process
GO:0035307positive regulation of protein dephosphorylationIDAbiological_process
GO:0003007heart morphogenesisISSbiological_process
GO:0030336negative regulation of cell migrationIMPbiological_process
GO:0006919activation of cysteine-type endopeptidase activityIDAbiological_process
GO:0008360regulation of cell shapeIMPbiological_process
GO:0048041focal adhesion assemblyIEAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0005737cytoplasmIDAcellular_component
GO:0042169SH2 domain bindingIPImolecular_function
GO:0048041focal adhesion assemblyISSbiological_process
GO:0005634nucleusIDAcellular_component
GO:0021575hindbrain morphogenesisISSbiological_process
GO:0007165signal transductionIEAbiological_process


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