| UniProt/SwissProt ID: | RHEB_HUMAN |
| Description: | Ras homolog enriched in brain [Source:HGNC Symbol;Acc:10011] |
| Location: | chr7 q36.1 |
| Node attribute: | PPI(target); kinase; PPI(source) |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S175 | MDGAAsQGKSS | PhosphoSitePlus | |
| S130 | MERVIsYEEGK | Ras | PhosphoSitePlus |
| Dephosphorylation site |
| RHEB_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000262187 | E139K | HPI | Colorectal Cancer | 16959974 | ENSP00000262187 | N79S | COSMIC | Lung Cancer | 20668451 | ENSP00000262187 | E139K | Sjoblom2006, COSMIC | Intestines Cancer | 16959974 |
| Differential expressed protein |
| RHEB_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| RHEB_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| RHEB_HUMAN | BRAF_HUMAN | kinase -> substrate | HPRD |
| RHEB_HUMAN | RAF1_HUMAN | kinase -> substrate | HPRD |
| TSC2_HUMAN | RHEB_HUMAN | other | KEGG |
| RHEB_HUMAN | MTOR_HUMAN | other | KEGG |
| RHEB_HUMAN | BRAF_HUMAN | other | KEGG |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04910 | Insulin signaling pathway |
| hsa04150 | mTOR signaling pathway |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0005681 | spliceosomal complex | IEA | cellular_component |
| GO:0019901 | protein kinase binding | IEA | molecular_function |
| GO:0019003 | GDP binding | IEA | molecular_function |
| GO:0007050 | cell cycle arrest | TAS | biological_process |
| GO:0003924 | GTPase activity | IEA | molecular_function |
| GO:0006184 | GTP catabolic process | IEA | biological_process |
| GO:0016020 | membrane | IEA | cellular_component |
| GO:0032008 | positive regulation of TOR signaling cascade | IEA | biological_process |
| GO:0007264 | small GTPase mediated signal transduction | IEA | biological_process |
| GO:0015031 | protein transport | IEA | biological_process |
| GO:0005886 | plasma membrane | IEA | cellular_component |
| GO:0008286 | insulin receptor signaling pathway | TAS | biological_process |
| GO:0005622 | intracellular | IEA | cellular_component |
| GO:0046872 | metal ion binding | IEA | molecular_function |
| GO:0043025 | neuronal cell body | IEA | cellular_component |
| GO:0005525 | GTP binding | IEA | molecular_function |
| GO:0007165 | signal transduction | TAS | biological_process |
| GO:0030425 | dendrite | IEA | cellular_component |
| GO:0005829 | cytosol | TAS | cellular_component |
| GO:0005515 | protein binding | IEA | molecular_function |