Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:RHEB_HUMAN
Description:Ras homolog enriched in brain [Source:HGNC Symbol;Acc:10011]
Location:chr7 q36.1
Node attribute:PPI(target); kinase; PPI(source)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S175MDGAAsQGKSSPhosphoSitePlus
S130MERVIsYEEGKRasPhosphoSitePlus

Dephosphorylation site
RHEB_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000262187E139KHPIColorectal Cancer16959974
ENSP00000262187N79SCOSMICLung Cancer20668451
ENSP00000262187E139KSjoblom2006, COSMICIntestines Cancer16959974

Differential expressed protein
RHEB_HUMAN is not differential expressed protein.

Hyperphosphorylation site
RHEB_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
RHEB_HUMANBRAF_HUMANkinase -> substrateHPRD
RHEB_HUMANRAF1_HUMANkinase -> substrateHPRD
TSC2_HUMANRHEB_HUMANotherKEGG
RHEB_HUMANMTOR_HUMANotherKEGG
RHEB_HUMANBRAF_HUMANotherKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04910Insulin signaling pathway
hsa04150mTOR signaling pathway

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005681spliceosomal complexIEAcellular_component
GO:0019901protein kinase bindingIEAmolecular_function
GO:0019003GDP bindingIEAmolecular_function
GO:0007050cell cycle arrestTASbiological_process
GO:0003924GTPase activityIEAmolecular_function
GO:0006184GTP catabolic processIEAbiological_process
GO:0016020membraneIEAcellular_component
GO:0032008positive regulation of TOR signaling cascadeIEAbiological_process
GO:0007264small GTPase mediated signal transductionIEAbiological_process
GO:0015031protein transportIEAbiological_process
GO:0005886plasma membraneIEAcellular_component
GO:0008286insulin receptor signaling pathwayTASbiological_process
GO:0005622intracellularIEAcellular_component
GO:0046872metal ion bindingIEAmolecular_function
GO:0043025neuronal cell bodyIEAcellular_component
GO:0005525GTP bindingIEAmolecular_function
GO:0007165signal transductionTASbiological_process
GO:0030425dendriteIEAcellular_component
GO:0005829cytosolTAScellular_component
GO:0005515protein bindingIEAmolecular_function


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