| UniProt/SwissProt ID: | RGS7_HUMAN |
| Description: | regulator of G-protein signaling 7 [Source:HGNC Symbol;Acc:10003] |
| Location: | chr1 q43 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S434 | LMKSDsYPRFI | PKC_alpha | phosphoELM |
| S434 | LMKSDsYPRFI | PKCa | RegPhos |
| S434 | LMKSDsYPRFI | RegPhos | |
| S434 | LMKSDsYPRFI | PRKCA | HPRD |
| T243 | RSHSPtHTPTP | FlxA | PhosphoSitePlus |
| S457 | KKSGNsMDRRT | PhosphoSitePlus | |
| S229 | HKTRKsVYGLQ | RegPhos | |
| S434 | LMKSDsYPRFI | PKCa(PKC alpha | RegPhos |
| S434 | LMKSDsYPRFI | RGS | PhosphoSitePlus |
| S241 | DIRSHsPTHTP | FlxA | PhosphoSitePlus |
| S323 | ASKEPsQQRVK | PhosphoSitePlus | |
| Dephosphorylation site |
| RGS7_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000355523 | R33W | COSMIC | Ovarian Cancer | 21720365 | ENSP00000355523 | F57L | COSMIC | Renal Cancer | 20054297 | ENSP00000355523 | L145H | COSMIC | Ovarian Cancer | 21720365 | ENSP00000355523 | S285R | COSMIC | Ovarian Cancer | 21720365 |
| Differential expressed protein |
| RGS7_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| RGS7_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| ZAGL2_HUMAN | RGS7_HUMAN | kinase -> substrate | RegPhos |
| KPCA_HUMAN | RGS7_HUMAN | kinase -> substrate | HPRD; Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| RGS7_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0005737 | cytoplasm | IBA | cellular_component |
| GO:0031681 | G-protein beta-subunit binding | IEA | molecular_function |
| GO:0007186 | G-protein coupled receptor signaling pathway | IEA | biological_process |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0043547 | positive regulation of GTPase activity | IBA | biological_process |
| GO:0005886 | plasma membrane | IEA | cellular_component |
| GO:0005886 | plasma membrane | IBA | cellular_component |
| GO:0004871 | signal transducer activity | IEA | molecular_function |
| GO:0008277 | regulation of G-protein coupled receptor protein s | NAS | biological_process |
| GO:0035556 | intracellular signal transduction | IEA | biological_process |
| GO:0043234 | protein complex | IEA | cellular_component |
| GO:0008277 | regulation of G-protein coupled receptor protein s | IEA | biological_process |
| GO:0038032 | termination of G-protein coupled receptor signalin | IEA | biological_process |
| GO:0044292 | dendrite terminus | IEA | cellular_component |
| GO:0005096 | GTPase activator activity | IBA | molecular_function |
| GO:0005634 | nucleus | IEA | cellular_component |
| GO:0005829 | cytosol | IEA | cellular_component |
| GO:0005834 | heterotrimeric G-protein complex | IEA | cellular_component |