Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:RGS14_HUMAN
Description:regulator of G-protein signaling 14 [Source:HGNC Symbol;Acc:9996]
Location:chr5 q35.3
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T495ATGKRqTCDIEPKA_groupRegPhos
T472TQDKAtHPPPAPhosphoSitePlus
S260ALRREsQGSLNPKA_groupphosphoELM; RegPhos
S510LNRVQsSGAHDGoLocoPhosphoSitePlus
T251RELGGtANAALPhosphoSitePlus
S48IHSLPsGPSSPPhosphoSitePlus
Y122EARNIyQEFLSRGSPhosphoSitePlus
S263RESQGsLNSSAPhosphoSitePlus
T496TGKRQtCDIEGPKACaRegPhos
S52PSGPSsPFPTEPhosphoSitePlus
T496TGKRQtCDIEGPKA_groupphosphoELM
T495TGKRQtCDIEGPRKACAHPRD
S539PAQGPsSEETPPhosphoSitePlus
S42RGSSLsIHSLPPhosphoSitePlus
S67ASWALsFERLLHPRD
S243RPLRKsFRRELPhosphoSitePlus
S218LKPGKsLPLGVPhosphoSitePlus; HPRD
S260ALRREsQGSLNPhosphoSitePlus
T495TGKRQtCDIEGPhosphoSitePlus
T490VPSSAtGKRQTPhosphoSitePlus
S20MVLAVsDGELSPhosphoSitePlus
S40EGRGSsLSIHSPhosphoSitePlus
S260ALRREsQGSLNPKACaRegPhos
S487LVKVPsSATGKPhosphoSitePlus
S260ALRREsQGSLNPRKACAHPRD
S480PPASPsSLVKVPhosphoSitePlus
S45SLSIHsLPSGPPhosphoSitePlus
S67ASWALsFERLLRGSPhosphoSitePlus
S288ESHRKsLGSTEPhosphoSitePlus
S203SSRLGsPDATRPhosphoSitePlus
S481PASPSsLVKVPPhosphoSitePlus
S478HPPPAsPSSLVPhosphoSitePlus

Dephosphorylation site
RGS14_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000386229A252VCOSMICLung Cancer
ENSP00000386229E398KCOSMICSkin Cancer21984974
ENSP00000386229D563NCOSMICHead and Neck Cancer21798893

Differential expressed protein
RGS14_HUMAN is not differential expressed protein.

Hyperphosphorylation site
RGS14_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
KPCA_HUMANRGS14_HUMANkinase -> substrateHPRD; Robert H Newman (2013)
SNRK_HUMANRGS14_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
RGS14_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0007059chromosome segregationIEAbiological_process
GO:0070373negative regulation of ERK1 and ERK2 cascadeISSbiological_process
GO:0045211postsynaptic membraneIEAcellular_component
GO:0007612learningIEAbiological_process
GO:0008277regulation of G-protein coupled receptor protein sIEAbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0005096GTPase activator activityIBAmolecular_function
GO:0043620regulation of DNA-dependent transcription in respoIEAbiological_process
GO:0030695GTPase regulator activityIEAmolecular_function
GO:0005813centrosomeIEAcellular_component
GO:0007612learningISSbiological_process
GO:0043547positive regulation of GTPase activityIBAbiological_process
GO:0008542visual learningIEAbiological_process
GO:0000922spindle poleIEAcellular_component
GO:0005874microtubuleIEAcellular_component
GO:0008017microtubule bindingIDAmolecular_function
GO:0048008platelet-derived growth factor receptor signaling IEAbiological_process
GO:0007616long-term memoryIEAbiological_process
GO:0005634nucleusISScellular_component
GO:0007165signal transductionIEAbiological_process
GO:0043197dendritic spineISScellular_component
GO:0016604nuclear bodyISScellular_component
GO:0030054cell junctionIEAcellular_component
GO:0007067mitosisIEAbiological_process
GO:0005634nucleusIEAcellular_component
GO:0016605PML bodyIEAcellular_component
GO:0010070zygote asymmetric cell divisionIEAbiological_process
GO:0006913nucleocytoplasmic transportIEAbiological_process
GO:0016604nuclear bodyIEAcellular_component
GO:0043197dendritic spineIEAcellular_component
GO:0008542visual learningISSbiological_process
GO:0005819spindleIDAcellular_component
GO:0006913nucleocytoplasmic transportISSbiological_process
GO:0070373negative regulation of ERK1 and ERK2 cascadeIEAbiological_process
GO:0014069postsynaptic densityISScellular_component
GO:0005092GDP-dissociation inhibitor activityIEAmolecular_function
GO:0014069postsynaptic densityIEAcellular_component
GO:0043407negative regulation of MAP kinase activityIEAbiological_process
GO:0031914negative regulation of synaptic plasticityISSbiological_process
GO:0007051spindle organizationIMPbiological_process
GO:0030425dendriteIEAcellular_component
GO:0038032termination of G-protein coupled receptor signalinIEAbiological_process
GO:0050769positive regulation of neurogenesisIEAbiological_process
GO:0060291long-term synaptic potentiationISSbiological_process
GO:0030159receptor signaling complex scaffold activityIEAmolecular_function
GO:0006979response to oxidative stressISSbiological_process
GO:0007616long-term memoryISSbiological_process
GO:0005092GDP-dissociation inhibitor activityIDAmolecular_function
GO:0000922spindle poleISScellular_component
GO:0005886plasma membraneISScellular_component
GO:0005819spindleIEAcellular_component
GO:0048008platelet-derived growth factor receptor signaling ISSbiological_process
GO:0043620regulation of DNA-dependent transcription in respoISSbiological_process
GO:0019901protein kinase bindingIEAmolecular_function
GO:0045111intermediate filament cytoskeletonIDAcellular_component
GO:0005737cytoplasmISScellular_component
GO:0043407negative regulation of MAP kinase activityISSbiological_process
GO:0030159receptor signaling complex scaffold activityISSmolecular_function
GO:0005057receptor signaling protein activityIEAmolecular_function
GO:0007051spindle organizationIEAbiological_process
GO:0030425dendriteISScellular_component
GO:0031914negative regulation of synaptic plasticityIEAbiological_process
GO:0006979response to oxidative stressIEAbiological_process
GO:0051301cell divisionIMPbiological_process
GO:0032794GTPase activating protein bindingIEAmolecular_function
GO:0060291long-term synaptic potentiationIEAbiological_process
GO:0005813centrosomeISScellular_component
GO:0008277regulation of G-protein coupled receptor protein sTASbiological_process
GO:0010070zygote asymmetric cell divisionISSbiological_process
GO:0007059chromosome segregationISSbiological_process
GO:0050769positive regulation of neurogenesisISSbiological_process
GO:0005057receptor signaling protein activityISSmolecular_function