Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:RGRF2_HUMAN
Description:Ras protein-specific guanine nucleotide-releasing factor 2 [Source:HGNC Symbol;Acc:9876]
Location:chr5 q14.1
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y97ALDKQyYFTVLPHPhosphoSitePlus
T855CRSPStPRHLRPhosphoSitePlus
S37KTAEAsRWHEKPHPhosphoSitePlus
T1111YRLKKtWAKVSRasGEFPhosphoSitePlus
S1000AECFEsLSAMERasGEFPhosphoSitePlus
S465FIRQGsLIQVPPhosphoSitePlus
S746RARKLsLTSPLRasGEF_NPhosphoSitePlus
S1002CFESLsAMELARasGEFPhosphoSitePlus
S737AVSRTsSPVRACDK5RegPhos
T748RKLSLtSPLNSRasGEF_NPhosphoSitePlus
Y1090RCLHNyNGVLERasGEFPhosphoSitePlus
S718LVDGKsPRLCRRasGEF_NPhosphoSitePlus
S471LIQVPsVERGKPhosphoSitePlus
Y1106NRSAIyRLKKTRasGEFPhosphoSitePlus
S749KLSLTsPLNSKRasGEF_NPhosphoSitePlus

Dephosphorylation site
RGRF2_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000265080R650*COSMICIntestines Cancer16959974
ENSP00000265080R650XBIOMARTColorectal Cancer21930507, 21930502
ENSP00000265080P1152LCOSMICSkin Cancer21984974
ENSP00000265080N707KTCGAOvarian Cancer21720365, 18772890
ENSP00000265080D1216ESjoblom2006, COSMIC, HPIBreast Cancer16959974
ENSP00000265080L568FCOSMICMelanoma
ENSP00000265080R912TCOSMICBreast Cancer20668451
ENSP00000265080T664NCOSMICOvarian Cancer20668451
ENSP00000265080R114HHPIColorectal Cancer16959974
ENSP00000265080R819*COSMICCentral Nervous System Neoplasms18772396
ENSP00000265080P766ACOSMICOvarian Cancer21720365
ENSP00000265080E176KCOSMICOvarian Cancer21720365
ENSP00000265080D538NSjoblom2006, COSMIC, HPIBreast Cancer16959974, 18428421
ENSP00000265080Y1106FCOSMICOvarian Cancer21720365
ENSP00000265080R114HSjoblom2006, COSMICIntestines Cancer16959974
ENSP00000265080I206MCOSMICHead and Neck Cancer21798893
ENSP00000265080P766ATCGAOvarian Cancer21720365, 18772890
ENSP00000265080N707KCOSMICOvarian Cancer21720365
ENSP00000265080L294FCOSMICBreast Cancer20668451

Differential expressed protein
RGRF2_HUMAN is not differential expressed protein.

Hyperphosphorylation site
RGRF2_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
CDK5_HUMANRGRF2_HUMANkinase -> substrateRegPhos

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04010MAPK signaling pathway

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005622intracellularIEAcellular_component
GO:0035023regulation of Rho protein signal transductionIEAbiological_process
GO:0051056regulation of small GTPase mediated signal transduTASbiological_process
GO:0005737cytoplasmIDAcellular_component
GO:0007264small GTPase mediated signal transductionTASbiological_process
GO:0005886plasma membraneTAScellular_component
GO:0048011nerve growth factor receptor signaling pathwayTASbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0005789endoplasmic reticulum membraneIEAcellular_component
GO:0005543phospholipid bindingIEAmolecular_function
GO:0005516calmodulin bindingIEAmolecular_function
GO:0005829cytosolTAScellular_component
GO:0005085guanyl-nucleotide exchange factor activityIEAmolecular_function
GO:0005089Rho guanyl-nucleotide exchange factor activityIEAmolecular_function
GO:0006915apoptotic processTASbiological_process
GO:0007268synaptic transmissionTASbiological_process