Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:RGAP1_HUMAN
Description:Rac GTPase activating protein 1 [Source:HGNC Symbol;Acc:9804]
Location:chr12 q13.12
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S112LMCDTsGSIQLDUF2968; CALCOCO1; Cep57_PhosphoSitePlus
T161ISFDKtDESLDHPRD; phosphoELM; RegPhos
S185REKRRsTSRQFAurBRegPhos
S591LKTPSsSSLSQPhosphoSitePlus; HPRD; phosphoELM
T201GPVKKtRSIGSHPRD
Y241IETVPyWTRSRPhosphoSitePlus; HPRD
T567FSTPQtPDIKVPhosphoSitePlus; HPRD
T603VRSTLtKNTPRPhosphoSitePlus; HPRD
S540PLEYWsQFMMVHPRD
S533VERLLsLPLEYHPRD
T405FLRVKtVPLLSRhoGAP; DUF547PhosphoSitePlus
S628GNFFAsPMLKRegPhos; SysPTM
T588HQLLKtPSSSSCDK1HPRD
S628GNFFAsPMLK_PhosphoSitePlus; SysPTM
T580LGPVTtPEHQLPhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM
S387GLYRIsGCDRTAurBRegPhos
S157ILSDIsFDKTDCALCOCO1; Cep57_CLDPhosphoSitePlus
T606TLTKNtPRFGSPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S151IDESGsILSDICALCOCO1; Cep57_CLDPhosphoSitePlus
S164DKTDEsLDWDSHPRD; phosphoELM; RegPhos
S387GLYRIsGCDRTRhoGAP; DUF547PhosphoSitePlus
S203VKKTRsIGSAVPhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM
S164DKTDEsLDWDSCALCOCO1PhosphoSitePlus
S170LDWDSsLVKTFCALCOCO1PhosphoSitePlus; SysPTM
S299VIKPEsCVPCGC1_1; Prok-RING_1PhosphoSitePlus
T277TDSVGtPQSNGPhosphoSitePlus; HPRD; phosphoELM
S387GLYRIsGCDRTAurB(Aurora BRegPhos
S157ILSDIsFDKTDHPRD; phosphoELM
T161ISFDKtDESLDCALCOCO1PhosphoSitePlus
T260WNSDStLNSRQPhosphoSitePlus
S600SQRVRsTLTKNPhosphoSitePlus; HPRD; phosphoELM
T251RRKTGtLQPWNPhosphoSitePlus; phosphoELM
S595SSSSLsQRVRSPhosphoSitePlus; HPRD; phosphoELM
T243TVPYWtRSRRKHPRD
T186EKRRStSRQFVPhosphoSitePlus
S234PIEAVsTIETVHPRD
S387GLYRIsGCDRTRegPhos
T601QRVRStLTKNTPhosphoSitePlus; HPRD; phosphoELM
S187KRRSTsRQFVDAurBRegPhos
T342PTLIGtPVKIGPhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM
S257LQPWNsDSTLNPhosphoSitePlus; HPRD; phosphoELM; SysPTM
S144GNKRLsTIDESAURKBHPRD
S169SLDWDsSLVKTHPRD
S628GNFFAsPMHPRD; phosphoELM; SysPTM
T145NKRLStIDESGAurBRegPhos
T145NKRLStIDESGAURKBHPRD
S410TVPLLsKVDDIAurora BphosphoELM
S206TRSIGsAVDQGPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S410TVPLLsKVDDIAURKBHPRD
S144GNKRLsTIDESCALCOCO1; Cep57_CLDPhosphoSitePlus
S280VGTPQsNGGMRPhosphoSitePlus
T186EKRRStSRQFVAURKBHPRD
T249RSRRKtGTLQPPhosphoSitePlus
S593TPSSSsLSQRVPhosphoSitePlus; HPRD
S185REKRRsTSRQFPhosphoSitePlus; phosphoELM; RegPhos
S313KFGKLsLKCRDC1_1; Prok-RING_1PhosphoSitePlus
S410TVPLLsKVDDIAurB(Aurora BRegPhos
S410TVPLLsKVDDIAurBRegPhos
S154SGSILsDISFDHPRD; phosphoELM
S169SLDWDsSLVKTCALCOCO1PhosphoSitePlus
T564SNAFStPQTPDPhosphoSitePlus; HPRD
S573PDIKVsLLGPVHPRD; phosphoELM
T145NKRLStIDESGCALCOCO1; Cep57_CLDPhosphoSitePlus
S185REKRRsTSRQFAURKBHPRD
T186EKRRStSRQFVAurBRegPhos
S144GNKRLsTIDESphosphoELM
S170LDWDSsLVKTFHPRD; phosphoELM; RegPhos; SysPTM
T579LLGPVtTPEHQPhosphoSitePlus; HPRD; phosphoELM
S592KTPSSsSLSQRPhosphoSitePlus; HPRD; phosphoELM
S149STIDEsGSILSHPRD; phosphoELM
T588HQLLKtPSSSSPhosphoSitePlus; phosphoELM; RegPhos
S154SGSILsDISFDCALCOCO1; Cep57_CLDPhosphoSitePlus
S187KRRSTsRQFVDAURKBHPRD
S187KRRSTsRQFVDPhosphoSitePlus; phosphoELM; RegPhos
S563NSNAFsTPQTPPhosphoSitePlus; HPRD
S590LLKTPsSSSLSPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S387GLYRIsGCDRTAURKBHPRD
S387GLYRIsGCDRTAurora BphosphoELM
S144GNKRLsTIDESAurBRegPhos
S214DQGNEsIVAKTPhosphoSitePlus; HPRD; phosphoELM; RegPhos

Dephosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T588PEHQLLKtPSSSSLSPPP2CAHPRD

Mutation site
RGAP1_HUMAN do not have mutation site.

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000413241Testicular CancerNormal vs. Cancercell lineUp18489135

Hyperphosphorylation site
RGAP1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
ZAGL2_HUMANRGAP1_HUMANkinase -> substrateRegPhos
AURKB_HUMANRGAP1_HUMANkinase -> substrateHPRD; Robert H Newman (2013)
CDK1_HUMANRGAP1_HUMANkinase -> substrateHPRD
PP2AA_HUMANRGAP1_HUMANphosphatase -> substrateHPRD

Function Annotation
KEGG Pathway
RGAP1_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0051056regulation of small GTPase mediated signal transduTASbiological_process
GO:0005829cytosolTAScellular_component
GO:0048487beta-tubulin bindingIDAmolecular_function
GO:0005874microtubuleIEAcellular_component
GO:0005622intracellularIEAcellular_component
GO:0032154cleavage furrowIDAcellular_component
GO:0071777positive regulation of cell cycle cytokinesisIMPbiological_process
GO:0007264small GTPase mediated signal transductionTASbiological_process
GO:0043014alpha-tubulin bindingIDAmolecular_function
GO:0043015gamma-tubulin bindingIDAmolecular_function
GO:0009790embryo developmentIEAbiological_process
GO:0008272sulfate transportIDAbiological_process
GO:0072686mitotic spindleIMPcellular_component
GO:0019886antigen processing and presentation of exogenous pTASbiological_process
GO:0007283spermatogenesisIEPbiological_process
GO:0005096GTPase activator activityIDAmolecular_function
GO:0035556intracellular signal transductionIEAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0043547positive regulation of GTPase activityIDAbiological_process
GO:0051233spindle midzoneIDAcellular_component
GO:0046872metal ion bindingIEAmolecular_function
GO:0007405neuroblast proliferationIEAbiological_process
GO:0007165signal transductionIEAbiological_process
GO:0000910cytokinesisIDAbiological_process
GO:0033205cell cycle cytokinesisIMPbiological_process
GO:0007596blood coagulationTASbiological_process
GO:0038032termination of G-protein coupled receptor signalinIEAbiological_process
GO:0051988regulation of attachment of spindle microtubules tIMPbiological_process
GO:0051256spindle midzone assembly involved in mitosisIDAbiological_process
GO:0030496midbodyIDAcellular_component
GO:0019901protein kinase bindingIPImolecular_function
GO:0007108cytokinesis, initiation of separationIMPbiological_process
GO:0097149centralspindlin complexIDAcellular_component
GO:0000915cytokinesis, actomyosin contractile ring assemblyIMPbiological_process
GO:0001669acrosomal vesicleIEAcellular_component
GO:0007018microtubule-based movementTASbiological_process
GO:0005634nucleusIDAcellular_component
GO:0008017microtubule bindingIDAmolecular_function


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