| UniProt/SwissProt ID: | RGAP1_HUMAN |
| Description: | Rac GTPase activating protein 1 [Source:HGNC Symbol;Acc:9804] |
| Location: | chr12 q13.12 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S112 | LMCDTsGSIQL | DUF2968; CALCOCO1; Cep57_ | PhosphoSitePlus |
| T161 | ISFDKtDESLD | HPRD; phosphoELM; RegPhos | |
| S185 | REKRRsTSRQF | AurB | RegPhos |
| S591 | LKTPSsSSLSQ | PhosphoSitePlus; HPRD; phosphoELM | |
| T201 | GPVKKtRSIGS | HPRD | |
| Y241 | IETVPyWTRSR | PhosphoSitePlus; HPRD | |
| T567 | FSTPQtPDIKV | PhosphoSitePlus; HPRD | |
| T603 | VRSTLtKNTPR | PhosphoSitePlus; HPRD | |
| S540 | PLEYWsQFMMV | HPRD | |
| S533 | VERLLsLPLEY | HPRD | |
| T405 | FLRVKtVPLLS | RhoGAP; DUF547 | PhosphoSitePlus |
| S628 | GNFFAsPMLK | RegPhos; SysPTM | |
| T588 | HQLLKtPSSSS | CDK1 | HPRD |
| S628 | GNFFAsPMLK_ | PhosphoSitePlus; SysPTM | |
| T580 | LGPVTtPEHQL | PhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM | |
| S387 | GLYRIsGCDRT | AurB | RegPhos |
| S157 | ILSDIsFDKTD | CALCOCO1; Cep57_CLD | PhosphoSitePlus |
| T606 | TLTKNtPRFGS | PhosphoSitePlus; HPRD; phosphoELM; RegPhos | |
| S151 | IDESGsILSDI | CALCOCO1; Cep57_CLD | PhosphoSitePlus |
| S164 | DKTDEsLDWDS | HPRD; phosphoELM; RegPhos | |
| S387 | GLYRIsGCDRT | RhoGAP; DUF547 | PhosphoSitePlus |
| S203 | VKKTRsIGSAV | PhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM | |
| S164 | DKTDEsLDWDS | CALCOCO1 | PhosphoSitePlus |
| S170 | LDWDSsLVKTF | CALCOCO1 | PhosphoSitePlus; SysPTM |
| S299 | VIKPEsCVPCG | C1_1; Prok-RING_1 | PhosphoSitePlus |
| T277 | TDSVGtPQSNG | PhosphoSitePlus; HPRD; phosphoELM | |
| S387 | GLYRIsGCDRT | AurB(Aurora B | RegPhos |
| S157 | ILSDIsFDKTD | HPRD; phosphoELM | |
| T161 | ISFDKtDESLD | CALCOCO1 | PhosphoSitePlus |
| T260 | WNSDStLNSRQ | PhosphoSitePlus | |
| S600 | SQRVRsTLTKN | PhosphoSitePlus; HPRD; phosphoELM | |
| T251 | RRKTGtLQPWN | PhosphoSitePlus; phosphoELM | |
| S595 | SSSSLsQRVRS | PhosphoSitePlus; HPRD; phosphoELM | |
| T243 | TVPYWtRSRRK | HPRD | |
| T186 | EKRRStSRQFV | PhosphoSitePlus | |
| S234 | PIEAVsTIETV | HPRD | |
| S387 | GLYRIsGCDRT | RegPhos | |
| T601 | QRVRStLTKNT | PhosphoSitePlus; HPRD; phosphoELM | |
| S187 | KRRSTsRQFVD | AurB | RegPhos |
| T342 | PTLIGtPVKIG | PhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM | |
| S257 | LQPWNsDSTLN | PhosphoSitePlus; HPRD; phosphoELM; SysPTM | |
| S144 | GNKRLsTIDES | AURKB | HPRD |
| S169 | SLDWDsSLVKT | HPRD | |
| S628 | GNFFAsPM | HPRD; phosphoELM; SysPTM | |
| T145 | NKRLStIDESG | AurB | RegPhos |
| T145 | NKRLStIDESG | AURKB | HPRD |
| S410 | TVPLLsKVDDI | Aurora B | phosphoELM |
| S206 | TRSIGsAVDQG | PhosphoSitePlus; HPRD; phosphoELM; RegPhos | |
| S410 | TVPLLsKVDDI | AURKB | HPRD |
| S144 | GNKRLsTIDES | CALCOCO1; Cep57_CLD | PhosphoSitePlus |
| S280 | VGTPQsNGGMR | PhosphoSitePlus | |
| T186 | EKRRStSRQFV | AURKB | HPRD |
| T249 | RSRRKtGTLQP | PhosphoSitePlus | |
| S593 | TPSSSsLSQRV | PhosphoSitePlus; HPRD | |
| S185 | REKRRsTSRQF | PhosphoSitePlus; phosphoELM; RegPhos | |
| S313 | KFGKLsLKCRD | C1_1; Prok-RING_1 | PhosphoSitePlus |
| S410 | TVPLLsKVDDI | AurB(Aurora B | RegPhos |
| S410 | TVPLLsKVDDI | AurB | RegPhos |
| S154 | SGSILsDISFD | HPRD; phosphoELM | |
| S169 | SLDWDsSLVKT | CALCOCO1 | PhosphoSitePlus |
| T564 | SNAFStPQTPD | PhosphoSitePlus; HPRD | |
| S573 | PDIKVsLLGPV | HPRD; phosphoELM | |
| T145 | NKRLStIDESG | CALCOCO1; Cep57_CLD | PhosphoSitePlus |
| S185 | REKRRsTSRQF | AURKB | HPRD |
| T186 | EKRRStSRQFV | AurB | RegPhos |
| S144 | GNKRLsTIDES | phosphoELM | |
| S170 | LDWDSsLVKTF | HPRD; phosphoELM; RegPhos; SysPTM | |
| T579 | LLGPVtTPEHQ | PhosphoSitePlus; HPRD; phosphoELM | |
| S592 | KTPSSsSLSQR | PhosphoSitePlus; HPRD; phosphoELM | |
| S149 | STIDEsGSILS | HPRD; phosphoELM | |
| T588 | HQLLKtPSSSS | PhosphoSitePlus; phosphoELM; RegPhos | |
| S154 | SGSILsDISFD | CALCOCO1; Cep57_CLD | PhosphoSitePlus |
| S187 | KRRSTsRQFVD | AURKB | HPRD |
| S187 | KRRSTsRQFVD | PhosphoSitePlus; phosphoELM; RegPhos | |
| S563 | NSNAFsTPQTP | PhosphoSitePlus; HPRD | |
| S590 | LLKTPsSSSLS | PhosphoSitePlus; HPRD; phosphoELM; RegPhos | |
| S387 | GLYRIsGCDRT | AURKB | HPRD |
| S387 | GLYRIsGCDRT | Aurora B | phosphoELM |
| S144 | GNKRLsTIDES | AurB | RegPhos |
| S214 | DQGNEsIVAKT | PhosphoSitePlus; HPRD; phosphoELM; RegPhos | |
| Dephosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| T588 | PEHQLLKtPSSSSLS | PPP2CA | HPRD |
| Mutation site |
| RGAP1_HUMAN do not have mutation site. |
| Differential expressed protein |
| Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
|---|---|---|---|---|---|---|
| ENSP00000413241 | Testicular Cancer | Normal vs. Cancer | cell line | Up | 18489135 | |
| Hyperphosphorylation site |
| RGAP1_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| ZAGL2_HUMAN | RGAP1_HUMAN | kinase -> substrate | RegPhos |
| AURKB_HUMAN | RGAP1_HUMAN | kinase -> substrate | HPRD; Robert H Newman (2013) |
| CDK1_HUMAN | RGAP1_HUMAN | kinase -> substrate | HPRD |
| PP2AA_HUMAN | RGAP1_HUMAN | phosphatase -> substrate | HPRD |
| Function Annotation |
| KEGG Pathway |
| RGAP1_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0051056 | regulation of small GTPase mediated signal transdu | TAS | biological_process |
| GO:0005829 | cytosol | TAS | cellular_component |
| GO:0048487 | beta-tubulin binding | IDA | molecular_function |
| GO:0005874 | microtubule | IEA | cellular_component |
| GO:0005622 | intracellular | IEA | cellular_component |
| GO:0032154 | cleavage furrow | IDA | cellular_component |
| GO:0071777 | positive regulation of cell cycle cytokinesis | IMP | biological_process |
| GO:0007264 | small GTPase mediated signal transduction | TAS | biological_process |
| GO:0043014 | alpha-tubulin binding | IDA | molecular_function |
| GO:0043015 | gamma-tubulin binding | IDA | molecular_function |
| GO:0009790 | embryo development | IEA | biological_process |
| GO:0008272 | sulfate transport | IDA | biological_process |
| GO:0072686 | mitotic spindle | IMP | cellular_component |
| GO:0019886 | antigen processing and presentation of exogenous p | TAS | biological_process |
| GO:0007283 | spermatogenesis | IEP | biological_process |
| GO:0005096 | GTPase activator activity | IDA | molecular_function |
| GO:0035556 | intracellular signal transduction | IEA | biological_process |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0043547 | positive regulation of GTPase activity | IDA | biological_process |
| GO:0051233 | spindle midzone | IDA | cellular_component |
| GO:0046872 | metal ion binding | IEA | molecular_function |
| GO:0007405 | neuroblast proliferation | IEA | biological_process |
| GO:0007165 | signal transduction | IEA | biological_process |
| GO:0000910 | cytokinesis | IDA | biological_process |
| GO:0033205 | cell cycle cytokinesis | IMP | biological_process |
| GO:0007596 | blood coagulation | TAS | biological_process |
| GO:0038032 | termination of G-protein coupled receptor signalin | IEA | biological_process |
| GO:0051988 | regulation of attachment of spindle microtubules t | IMP | biological_process |
| GO:0051256 | spindle midzone assembly involved in mitosis | IDA | biological_process |
| GO:0030496 | midbody | IDA | cellular_component |
| GO:0019901 | protein kinase binding | IPI | molecular_function |
| GO:0007108 | cytokinesis, initiation of separation | IMP | biological_process |
| GO:0097149 | centralspindlin complex | IDA | cellular_component |
| GO:0000915 | cytokinesis, actomyosin contractile ring assembly | IMP | biological_process |
| GO:0001669 | acrosomal vesicle | IEA | cellular_component |
| GO:0007018 | microtubule-based movement | TAS | biological_process |
| GO:0005634 | nucleus | IDA | cellular_component |
| GO:0008017 | microtubule binding | IDA | molecular_function |