| UniProt/SwissProt ID: | RFWD2_HUMAN |
| Description: | ring finger and WD repeat domain 2, E3 ubiquitin protein ligase [Source:HGNC Symbol;Acc:17440] |
| Location: | chr1 q25.2 |
| Node attribute: | gene |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| Y371 | DLEQCyFSTRM | PhosphoSitePlus | |
| S387 | DSRTAsQLDEF | PhosphoSitePlus | |
| T25 | AASSVtSASSS | PhosphoSitePlus | |
| Dephosphorylation site |
| RFWD2_HUMAN do not have dephosphorylation site. |
| Mutation site |
| RFWD2_HUMAN do not have mutation site. |
| Differential expressed protein |
| RFWD2_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| Site | Motif | Peptide | Cancer name | Pubmed | Source |
|---|---|---|---|---|---|
| S387 | SDDSRTAsQLDEFQE | ataxia-telangiectasic cancer | 16931761 | PhosphoSitePlus | |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| P53_HUMAN | RFWD2_HUMAN | TF -> target gene | KEGG |
| P53_HUMAN | RFWD2_HUMAN | TF -> target gene | TRANSFAC |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04115 | p53 signaling pathway |
| hsa04120 | Ubiquitin mediated proteolysis |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0005654 | nucleoplasm | TAS | cellular_component |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0016874 | ligase activity | IEA | molecular_function |
| GO:0016567 | protein ubiquitination | IEA | biological_process |
| GO:0005737 | cytoplasm | IDA | cellular_component |
| GO:0005634 | nucleus | IDA | cellular_component |
| GO:0016607 | nuclear speck | IEA | cellular_component |
| GO:0000075 | cell cycle checkpoint | TAS | biological_process |
| GO:0006977 | DNA damage response, signal transduction by p53 cl | TAS | biological_process |
| GO:0008270 | zinc ion binding | IEA | molecular_function |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0005813 | centrosome | IDA | cellular_component |
| GO:0005829 | cytosol | TAS | cellular_component |
| GO:0005925 | focal adhesion | IDA | cellular_component |