Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:RFC5_HUMAN
Description:replication factor C (activator 1) 5, 36.5kDa [Source:HGNC Symbol;Acc:9973]
Location:chr12 q24.23
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T178RFGPLtPELMVPhosphoSitePlus
S313IEYRLsVGTNERep_fac_CPhosphoSitePlus

Dephosphorylation site
RFC5_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000408295R168HBIOMARTBreast Cancer21930507, 21930502
ENSP00000376325R147HBIOMARTBreast Cancer21930507, 21930502

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000408295Breast CancerNormal vs. CancertissueDown0.316470630

Hyperphosphorylation site
RFC5_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
STK40_HUMANRFC5_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
RFC5_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0000084S phase of mitotic cell cycleTASbiological_process
GO:0017111nucleoside-triphosphatase activityIEAmolecular_function
GO:0005663DNA replication factor C complexIDAcellular_component
GO:0032201telomere maintenance via semi-conservative replicaTASbiological_process
GO:0009378four-way junction helicase activityIEAmolecular_function
GO:0000722telomere maintenance via recombinationTASbiological_process
GO:0006271DNA strand elongation involved in DNA replicationTASbiological_process
GO:0005654nucleoplasmTAScellular_component
GO:0000075cell cycle checkpointTASbiological_process
GO:0006260DNA replicationIEAbiological_process
GO:0019899enzyme bindingNASmolecular_function
GO:0000278mitotic cell cycleTASbiological_process
GO:0005524ATP bindingIEAmolecular_function
GO:0006289nucleotide-excision repairTASbiological_process
GO:0006310DNA recombinationIEAbiological_process
GO:0003677DNA bindingIEAmolecular_function
GO:0006281DNA repairNASbiological_process
GO:0000723telomere maintenanceTASbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0000166nucleotide bindingIEAmolecular_function
GO:0006283transcription-coupled nucleotide-excision repairTASbiological_process
GO:0006297nucleotide-excision repair, DNA gap fillingTASbiological_process


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