Phosphorylation

Protein information

UniProt/SwissProt ID:	RFC5_HUMAN
Description:	replication factor C (activator 1) 5, 36.5kDa [Source:HGNC Symbol;Acc:9973]
Location:	chr12 q24.23
Node attribute:	substrate

Position	PhosphoPeptide	Catalytic kinase	Source
T178	RFGPLtPELMV		PhosphoSitePlus
S313	IEYRLsVGTNE	Rep_fac_C	PhosphoSitePlus

RFC5_HUMAN do not have dephosphorylation site.

Ensembl ID	Variation	Source	Cancer name	Pubmed
ENSP00000408295	R168H	BIOMART	Breast Cancer	21930507, 21930502
ENSP00000376325	R147H	BIOMART	Breast Cancer	21930507, 21930502

Ensembl ID	Cancer name	Design	Sample	Change	Ratio	Pubmed
ENSP00000408295	Breast Cancer	Normal vs. Cancer	tissue	Down	0.3	16470630

RFC5_HUMAN do not have hyperphosphorylation site.

Source	Target	Relationship	Resource
STK40_HUMAN	RFC5_HUMAN	kinase -> substrate	Robert H Newman (2013)

KEGG Pathway

RFC5_HUMAN is not in KEGG pathway.

Gene Ontology

GO ID	GO_Term	Evidence	Ontology
GO:0000084	S phase of mitotic cell cycle	TAS	biological_process
GO:0017111	nucleoside-triphosphatase activity	IEA	molecular_function
GO:0005663	DNA replication factor C complex	IDA	cellular_component
GO:0032201	telomere maintenance via semi-conservative replica	TAS	biological_process
GO:0009378	four-way junction helicase activity	IEA	molecular_function
GO:0000722	telomere maintenance via recombination	TAS	biological_process
GO:0006271	DNA strand elongation involved in DNA replication	TAS	biological_process
GO:0005654	nucleoplasm	TAS	cellular_component
GO:0000075	cell cycle checkpoint	TAS	biological_process
GO:0006260	DNA replication	IEA	biological_process
GO:0019899	enzyme binding	NAS	molecular_function
GO:0000278	mitotic cell cycle	TAS	biological_process
GO:0005524	ATP binding	IEA	molecular_function
GO:0006289	nucleotide-excision repair	TAS	biological_process
GO:0006310	DNA recombination	IEA	biological_process
GO:0003677	DNA binding	IEA	molecular_function
GO:0006281	DNA repair	NAS	biological_process
GO:0000723	telomere maintenance	TAS	biological_process
GO:0005515	protein binding	IPI	molecular_function
GO:0000166	nucleotide binding	IEA	molecular_function
GO:0006283	transcription-coupled nucleotide-excision repair	TAS	biological_process
GO:0006297	nucleotide-excision repair, DNA gap filling	TAS	biological_process

Human Phosphorylation Mediated
Signaling Transduction Network