Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:RBL2_HUMAN
Description:retinoblastoma-like 2 (p130) [Source:HGNC Symbol;Acc:9894]
Location:chr16 q12.2
Node attribute:substrate; gene

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S982VPQPSsAPPTPCDK2RegPhos
Y670TLYDRySSPPAPhosphoSitePlus
S413YIKENsPCVTPCDK_groupphosphoELM; RegPhos
T974MRSSStLPVPQHPRD; phosphoELM; RegPhos
S981PVPQPsSAPPTHPRD; phosphoELM; RegPhos
T1097IRTGEtPTKKRPhosphoSitePlus; HPRD; RegPhos
S639ICIAGsPLTPRCDK2phosphoELM; RegPhos
S676SSPPAsTTRRRPhosphoSitePlus
T1019IKQIKtFAMKYRB_BPhosphoSitePlus
T642AGSPLtPRRVTCDK2phosphoELM; RegPhos
S1068NETMLsPREKICDK2phosphoELM; RegPhos
T417NSPCVtPVSTAHPRD; RegPhos
S1035DAPPLsPYPFVPhosphoSitePlus; HPRD; RegPhos
S1080YYFSNsPSKRLCDK2phosphoELM; RegPhos
S966TSRDSsPVMRSHPRD; phosphoELM; RegPhos
S952RSHQNsPTELNCDK2phosphoELM; RegPhos
S639ICIAGsPLTPRPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S98VACRKsVPTVSTFIIB; DUF3452PhosphoSitePlus
S948SSDSRsHQNSPRB_B; BCS1_NPhosphoSitePlus
T401ALRIStPLTGVCDK6phosphoELM; RegPhos
S672YDRYSsPPASTPhosphoSitePlus; HPRD; RegPhos
S972PVMRSsSTLPVHPRD; phosphoELM; RegPhos
T665ITSPTtLYDRYPhosphoSitePlus
S948SSDSRsHQNSPHPRD; phosphoELM; RegPhos
Y667SPTTLyDRYSSPhosphoSitePlus
S366EIGTLsRCLNAPhosphoSitePlus
T974MRSSStLPVPQRB_B; BCS1_NPhosphoSitePlus
S1112EDGSEsPAKRICDK2phosphoELM; RegPhos
S1068NETMLsPREKIPhosphoSitePlus; HPRD; RegPhos
T694PSDGGtPGRMPPhosphoSitePlus; HPRD; RegPhos
S1044FVRTGsPRRIQPhosphoSitePlus; HPRD; RegPhos
T986SSAPPtPTRLTHPRD; phosphoELM; RegPhos
S1059HPVYIsPHKNEPhosphoSitePlus
S672YDRYSsPPASTCDK6phosphoELM; RegPhos
S973VMRSSsTLPVPCDK2RegPhos
S662GRSITsPTTLYCDK_groupphosphoELM; RegPhos
S1035DAPPLsPYPFVCDK4phosphoELM; RegPhos
S1035DAPPLsPYPFVCDK6phosphoELM; RegPhos
T404ISTPLtGVRYIPhosphoSitePlus
T1097IRTGEtPTKKRCDK2phosphoELM; RegPhos
T417NSPCVtPVSTACDK_groupphosphoELM; RegPhos
S672YDRYSsPPASTCDK4phosphoELM; RegPhos
S1112EDGSEsPAKRICDK_groupphosphoELM; RegPhos
S1080YYFSNsPSKRLPhosphoSitePlus; HPRD; RegPhos
S982VPQPSsAPPTPRB_BPhosphoSitePlus
T401ALRIStPLTGVPhosphoSitePlus; HPRD; RegPhos
T961LNKDRtSRDSSRB_B; BCS1_NPhosphoSitePlus
S1044FVRTGsPRRIQCDK2phosphoELM; RegPhos
T1097IRTGEtPTKKRCDK_groupphosphoELM; RegPhos
S1068NETMLsPREKICDK_groupphosphoELM; RegPhos
S952RSHQNsPTELNHPRD; phosphoELM; RegPhos
S973VMRSSsTLPVPRB_B; BCS1_NPhosphoSitePlus
S1090LREINsMIRTGPhosphoSitePlus
S113EGNYVsLTRILDUF3452PhosphoSitePlus
S971SPVMRsSSTLPRB_B; BCS1_NPhosphoSitePlus
T642AGSPLtPRRVTCDK_groupphosphoELM; RegPhos
S662GRSITsPTTLYPhosphoSitePlus; HPRD; RegPhos
S981PVPQPsSAPPTRB_BPhosphoSitePlus
T417NSPCVtPVSTACDK2phosphoELM; RegPhos
T988APPTPtRLTGARB_BPhosphoSitePlus
S659GGLGRsITSPTPhosphoSitePlus; phosphoELM
S962NKDRTsRDSSPRB_B; BCS1_NPhosphoSitePlus
T661LGRSItSPTTLPhosphoSitePlus
S1112EDGSEsPAKRIPhosphoSitePlus; HPRD; RegPhos
T647TPRRVtEVRADPhosphoSitePlus
S952RSHQNsPTELNRB_B; BCS1_NPhosphoSitePlus
T1042YPFVRtGSPRRPhosphoSitePlus
S688FVENDsPSDGGPhosphoSitePlus; HPRD; RegPhos
T664SITSPtTLYDRPhosphoSitePlus
T364EEEIGtLSRCLPhosphoSitePlus
T678PPASTtRRRLFPhosphoSitePlus
S690ENDSPsDGGTPPhosphoSitePlus
T417NSPCVtPVSTARB_APhosphoSitePlus
S982VPQPSsAPPTPHPRD; phosphoELM; RegPhos
S995LTGANsDMEEERB_BPhosphoSitePlus
S962NKDRTsRDSSPHPRD; phosphoELM; RegPhos
S662GRSITsPTTLYCDK2phosphoELM; RegPhos
Y1037PPLSPyPFVRTPhosphoSitePlus
S1044FVRTGsPRRIQCDK_groupphosphoELM; RegPhos
S413YIKENsPCVTPPhosphoSitePlus; HPRD; RegPhos
T1019IKQIKtFAMKYRegPhos
T642AGSPLtPRRVTPhosphoSitePlus; HPRD; RegPhos
T986SSAPPtPTRLTRB_BPhosphoSitePlus
S688FVENDsPSDGGCDK2phosphoELM; RegPhos
S603AWKPEsPLWEKRB_APhosphoSitePlus
Y111TVEGNyVSLTRDUF3452PhosphoSitePlus
Y1057QNHPVyISPHKPhosphoSitePlus
S972PVMRSsSTLPVRB_B; BCS1_NPhosphoSitePlus
S688FVENDsPSDGGCDK_groupphosphoELM; RegPhos
T115NYVSLtRILKCDUF3452PhosphoSitePlus
S971SPVMRsSSTLPHPRD; phosphoELM; RegPhos
T694PSDGGtPGRMPCDK2phosphoELM; RegPhos
S966TSRDSsPVMRSRB_B; BCS1_NPhosphoSitePlus
T401ALRIStPLTGVCDK4phosphoELM; RegPhos
S1080YYFSNsPSKRLCDK_groupphosphoELM; RegPhos
S373CLNAGsGTETAPhosphoSitePlus
S973VMRSSsTLPVPHPRD; phosphoELM; RegPhos
S413YIKENsPCVTPCDK2phosphoELM; RegPhos
T694PSDGGtPGRMPCDK_groupphosphoELM; RegPhos
T1065PHKNEtMLSPRPhosphoSitePlus

Dephosphorylation site
RBL2_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000262133S1090ICOSMICOvarian Cancer21720365
ENSP00000262133P168LDing2008, COSMICLung Cancer18948947
ENSP00000262133K1100NBIOMARTHepatocellular Carcinoma21930507, 21930502
ENSP00000262133P547ATCGAOvarian Cancer21720365, 18772890
ENSP00000262133V823ICOSMICHead and Neck Cancer21798897
ENSP00000262133S972GCOSMICCentral Nervous System Neoplasms21817013
ENSP00000262133T742MCOSMICOvarian Cancer21720365
ENSP00000262133R367KDing2008, COSMICLung Cancer18948947
ENSP00000262133P547ACOSMICOvarian Cancer21720365
ENSP00000262133S1090ITCGAOvarian Cancer21720365, 18772890

Differential expressed protein
RBL2_HUMAN is not differential expressed protein.

Hyperphosphorylation site
RBL2_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
ZAGL2_HUMANRBL2_HUMANkinase -> substrateRegPhos
CDK2_HUMANRBL2_HUMANkinase -> substrateRegPhos
CDK4_HUMANRBL2_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
CDK6_HUMANRBL2_HUMANkinase -> substrateRegPhos; Robert H Newman (2013)
FOXO4_HUMANRBL2_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05203Viral carcinogenesis
hsa04350TGF-beta signaling pathway
hsa04110Cell cycle

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005667transcription factor complexIEAcellular_component
GO:0006355regulation of transcription, DNA-dependentIEAbiological_process
GO:0000080G1 phase of mitotic cell cycleTASbiological_process
GO:0051726regulation of cell cycleIEAbiological_process
GO:0005634nucleusIDAcellular_component
GO:0006351transcription, DNA-dependentIEAbiological_process
GO:0005515protein bindingIEAmolecular_function
GO:0005737cytoplasmIDAcellular_component
GO:0043550regulation of lipid kinase activityIDAbiological_process
GO:0005654nucleoplasmTAScellular_component
GO:0005730nucleolusIDAcellular_component
GO:0003677DNA bindingIEAmolecular_function
GO:0000278mitotic cell cycleTASbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0005634nucleusIEAcellular_component
GO:0016568chromatin modificationIEAbiological_process