Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:RAN_HUMAN
Description:RAN, member RAS oncogene family [Source:HGNC Symbol;Acc:9846]
Location:chr12 q24.33
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y146KKNLQyYDISAHPRD
Y147KNLQYyDISAKHPRD; phosphoELM
Y146KKNLQyYDISARasPhosphoSitePlus
S135KVKAKsIVFHRHPRD
Y147KNLQYyDISAKRasPhosphoSitePlus
Y39EFEKKyVATLGRasPhosphoSitePlus
S135KVKAKsIVFHRRasPhosphoSitePlus
Y155SAKSNyNFEKPRasPhosphoSitePlus
Y155SAKSNyNFEKPHPRD; phosphoELM

Dephosphorylation site
RAN_HUMAN do not have dephosphorylation site.

Mutation site
RAN_HUMAN do not have mutation site.

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000376176Uterine CancerNormal vs. CancertissueUp17902640
ENSP00000376176Non-small cell lung carcinomaTreatment (none vs CIGB-300 treatment)cell lineDown0.320804217
ENSP00000376176Breast CancerNormal vs. CancertissueUp6.720005186
ENSP00000376176Breast CancerNormal vs. CancertissueUp0.4320739354
ENSP00000376176breast ductal carcinomaNormal vs. CancertissueUp18564057
ENSP00000376176acute myeloid leukemiaTreatment (none vs. NSC606985 treatment)cell lineUp6.617655343
ENSP00000376176acute myeloid leukemiaTreatment (none vs. NSC606985 treatment)cell lineDown0.317655343
ENSP00000376176Neoplasms by Histologic TypeTreatment (none vs. SB203580 treatment 3 hour)cell lineDown0.1315169874
ENSP00000376176Testicular CancerNormal vs. Cancercell lineUp18489135
ENSP00000376176Pancreatic CancerNormal vs. CancertissueUp315526344
ENSP00000376176Uterine CancerNormal vs. Cancercell lineUp1015838902

Hyperphosphorylation site
RAN_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
CDK5_HUMANRAN_HUMANkinase -> substrateRobert H Newman (2013)
STK16_HUMANRAN_HUMANkinase -> substrateRobert H Newman (2013)
ST17A_HUMANRAN_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
RAN_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0000785chromatinIDAcellular_component
GO:0005643nuclear poreNAScellular_component
GO:0006913nucleocytoplasmic transportIEAbiological_process
GO:0019058viral infectious cycleTASbiological_process
GO:0005525GTP bindingIEAmolecular_function
GO:0006259DNA metabolic processTASbiological_process
GO:0003682chromatin bindingTASmolecular_function
GO:0005737cytoplasmIDAcellular_component
GO:0003713transcription coactivator activityNASmolecular_function
GO:0032092positive regulation of protein bindingIDAbiological_process
GO:0007067mitosisTASbiological_process
GO:0005622intracellularIEAcellular_component
GO:0005515protein bindingIEAmolecular_function
GO:0006405RNA export from nucleusNASbiological_process
GO:0006606protein import into nucleusIEAbiological_process
GO:0019048virus-host interactionIEAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0034629cellular protein complex localizationIEAbiological_process
GO:0050681androgen receptor bindingNASmolecular_function
GO:0016020membraneIEAcellular_component
GO:0005737cytoplasmIEAcellular_component
GO:0007264small GTPase mediated signal transductionIEAbiological_process
GO:0005829cytosolTAScellular_component
GO:0034613cellular protein localizationIEAbiological_process
GO:0005634nucleusIEAcellular_component
GO:0015031protein transportIEAbiological_process
GO:0005654nucleoplasmTAScellular_component
GO:0006184GTP catabolic processIEAbiological_process
GO:0030521androgen receptor signaling pathwayNASbiological_process
GO:0016032viral reproductionTASbiological_process
GO:0030036actin cytoskeleton organizationIEAbiological_process
GO:0045893positive regulation of transcription, DNA-dependenNASbiological_process
GO:0042470melanosomeIEAcellular_component
GO:0010467gene expressionTASbiological_process
GO:0051301cell divisionIEAbiological_process
GO:0003924GTPase activityIEAmolecular_function
GO:0006886intracellular protein transportIEAbiological_process
GO:0007052mitotic spindle organizationTASbiological_process
GO:0006611protein export from nucleusNASbiological_process
GO:0007165signal transductionTASbiological_process