| UniProt/SwissProt ID: | RAD50_HUMAN |
| Description: | RAD50 homolog (S. cerevisiae) [Source:HGNC Symbol;Acc:9816] |
| Location: | chr5 q31.1 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| T198 | RQVRQtQGQKV | PhosphoSitePlus | |
| T690 | QRVFQtEAELQ | HPRD; phosphoELM; RegPhos; SysPTM | |
| S635 | FDVCGsQDFES | PhosphoSitePlus; HPRD; phosphoELM; RegPhos; SysPTM | |
| T1113 | MIVMRtTELVN | PhosphoSitePlus | |
| T536 | HTTTRtQMEML | HPRD | |
| S237 | AQLTSsKEIVK | RegPhos | |
| T690 | QRVFQtEAELQ | Rad50_zn_hook | PhosphoSitePlus; SysPTM |
| S557 | IRKIKsRHSDE | HPRD | |
| Y1125 | DLDIYyKTLDQ | PhosphoSitePlus | |
| S640 | SQDFEsDLDRL | PhosphoSitePlus; HPRD; phosphoELM; RegPhos | |
| S635 | FDVCGsQDFES | ATM | phosphoELM; RegPhos; SysPTM |
| T1114 | IVMRTtELVNK | PhosphoSitePlus | |
| S560 | IKSRHsDELTS | HPRD | |
| Dephosphorylation site |
| RAD50_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000265335 | A1248G | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000265335 | N494K | BIOMART | Hepatocellular Carcinoma | 21930507, 21930502 |
| Differential expressed protein |
| Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
|---|---|---|---|---|---|---|
| ENSP00000265335 | Gastric Cancer | Metastasis | cell line | Down | 0.58 | 17022644 | ENSP00000265335 | Breast Cancer | Normal vs. Cancer | cell line | Up | 3.3 | 17022634 | ENSP00000265335 | Gastric Cancer | Metastasis | cell line | Down | 0.58 | 17022644 |
| Hyperphosphorylation site |
| RAD50_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| ZAGL2_HUMAN | RAD50_HUMAN | kinase -> substrate | RegPhos |
| ATM_HUMAN | RAD50_HUMAN | kinase -> substrate | RegPhos |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa03450 | Non-homologous end-joining |
| hsa03440 | Homologous recombination |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0006281 | DNA repair | IDA | biological_process |
| GO:0004003 | ATP-dependent DNA helicase activity | IMP | molecular_function |
| GO:0007004 | telomere maintenance via telomerase | IDA | biological_process |
| GO:0000724 | double-strand break repair via homologous recombin | TAS | biological_process |
| GO:0032508 | DNA duplex unwinding | IMP | biological_process |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0008270 | zinc ion binding | IEA | molecular_function |
| GO:0004518 | nuclease activity | IEA | molecular_function |
| GO:0000784 | nuclear chromosome, telomeric region | IDA | cellular_component |
| GO:0045120 | pronucleus | IEA | cellular_component |
| GO:0006310 | DNA recombination | IDA | biological_process |
| GO:0031954 | positive regulation of protein autophosphorylation | IDA | biological_process |
| GO:0033674 | positive regulation of kinase activity | IDA | biological_process |
| GO:0005654 | nucleoplasm | TAS | cellular_component |
| GO:0000723 | telomere maintenance | TAS | biological_process |
| GO:0007131 | reciprocal meiotic recombination | TAS | biological_process |
| GO:0003677 | DNA binding | IDA | molecular_function |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0006974 | response to DNA damage stimulus | IDA | biological_process |
| GO:0030674 | protein binding, bridging | IDA | molecular_function |
| GO:0005634 | nucleus | IEA | cellular_component |
| GO:0000014 | single-stranded DNA specific endodeoxyribonuclease | IDA | molecular_function |
| GO:0030870 | Mre11 complex | IDA | cellular_component |
| GO:0000019 | regulation of mitotic recombination | IDA | biological_process |
| GO:0006302 | double-strand break repair | IMP | biological_process |
| GO:0008408 | 3'-5' exonuclease activity | IDA | molecular_function |