| UniProt/SwissProt ID: | PYGB_HUMAN |
| Description: | phosphorylase, glycogen; brain [Source:HGNC Symbol;Acc:9723] |
| Location: | chr20 p11.21 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| Y473 | VFKDFyELEPE | Phosphorylase | PhosphoSitePlus |
| Y204 | LPVHFyGRVEH | Phosphorylase | PhosphoSitePlus |
| Y733 | NAREYyDHLPE | Phosphorylase | PhosphoSitePlus |
| T210 | GRVEHtPDGVK | Phosphorylase | PhosphoSitePlus |
| Y227 | VLAMPyDTPVP | Phosphorylase | PhosphoSitePlus |
| Y162 | GYGIRyEFGIF | HPRD | |
| Y75 | RTQQHyYERDP | PhosphoSitePlus | |
| Y162 | GYGIRyEFGIF | Phosphorylase | PhosphoSitePlus |
| S562 | KINPSsMFDVH | HPRD | |
| S430 | RLRRMsVIEEG | Phosphorylase | PhosphoSitePlus |
| T372 | EITKKtCAYTN | Phosphorylase | PhosphoSitePlus |
| S15 | KRKQIsVRGLA | PHK_group | phosphoELM; SysPTM |
| Y76 | TQQHYyERDPK | PhosphoSitePlus; HPRD; phosphoELM | |
| Y263 | FNVGDyIEAVL | Phosphorylase | PhosphoSitePlus |
| Y186 | DDWLRyGNPWE | Phosphorylase | PhosphoSitePlus |
| Y197 | KARPEyMLPVH | HPRD; phosphoELM | |
| T6 | SEKR | HPRD | |
| Y197 | KARPEyMLPVH | Phosphorylase | PhosphoSitePlus |
| Y732 | YNAREyYDHLP | Phosphorylase | PhosphoSitePlus |
| T229 | AMPYDtPVPGY | Phosphorylase | PhosphoSitePlus |
| S15 | KRKQIsVRGLA | PhosphoSitePlus; HPRD; phosphoELM; SysPTM | |
| Y554 | FLEKEyKVKIN | Phosphorylase | PhosphoSitePlus |
| T241 | NNTVNtMRLWS | Phosphorylase | PhosphoSitePlus |
| Y727 | LDRKGyNAREY | Phosphorylase | PhosphoSitePlus |
| Y281 | ISRVLyPNDNF | Phosphorylase | PhosphoSitePlus |
| S562 | KINPSsMFDVH | Phosphorylase | PhosphoSitePlus |
| Dephosphorylation site |
| PYGB_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000216962 | Q337* | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000216962 | F480L | COSMIC | Melanoma | 21499247 | ENSP00000216962 | A303S | BIOMART | Gastric Cancer | 21930507, 21930502 | ENSP00000216962 | I818V | COSMIC | Head and Neck Cancer | 21798893 |
| Differential expressed protein |
| Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
|---|---|---|---|---|---|---|
| ENSP00000216962 | Hepatocellular Carcinoma | Normal vs. Cancer | cell line | Up | 5.4 | 18646787 | ENSP00000216962 | Hepatocellular Carcinoma | Normal vs. Cancer | cell line | Up | 2.9 | 18646787 | ENSP00000216962 | Gastric Cancer | Normal vs. Cancer | tissue | Down | 0.41 | 19330469 | ENSP00000216962 | Breast Cancer | Normal vs. Cancer | tissue | Down | 0.44 | 20739354 | ENSP00000216962 | Gastric Cancer | Normal vs. Cancer | cell line | Up | 1.5 | 20812763 | ENSP00000216962 | Gastric Cancer | Normal vs. Cancer | cell line | Up | 3.8 | 20812763 |
| Hyperphosphorylation site |
| PYGB_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| CALL6_HUMAN | PYGB_HUMAN | kinase -> substrate | KEGG |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04910 | Insulin signaling pathway |
| hsa00500 | Starch and sucrose metabolism |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0005737 | cytoplasm | IDA | cellular_component |
| GO:0005975 | carbohydrate metabolic process | TAS | biological_process |
| GO:0005980 | glycogen catabolic process | NAS | biological_process |
| GO:0008184 | glycogen phosphorylase activity | NAS | molecular_function |
| GO:0030170 | pyridoxal phosphate binding | IEA | molecular_function |
| GO:0044281 | small molecule metabolic process | TAS | biological_process |
| GO:0004645 | phosphorylase activity | IEA | molecular_function |
| GO:0006006 | glucose metabolic process | TAS | biological_process |