Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:PTPRS_HUMAN
Description:protein tyrosine phosphatase, receptor type, S [Source:HGNC Symbol;Acc:9681]
Location:chr19 p13.3
Node attribute:receptor

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T1694NSKAHtSRFISPhosphoSitePlus
T1835DGQSRtVRQFQY_phosphatasePhosphoSitePlus
T803NLQPEtAYSITfn3PhosphoSitePlus
S1833ARDGQsRTVRQY_phosphatasePhosphoSitePlus
Y1422KPKNRyANVIAY_phosphatasePhosphoSitePlus
S893DRYTAsGVHKGfn3PhosphoSitePlus
Y1818YNMPQyILREFY_phosphatasePhosphoSitePlus
S383GLSPNsEYEIWHPRD
Y1662PARSLyAYIQKPhosphoSitePlus
T1486EQRSAtIVMMTY_phosphatasePhosphoSitePlus
Y1397KLSQEyESIDPPhosphoSitePlus
Y1939QAALEyLGSFDPhosphoSitePlus
S1695SKAHTsRFISAPhosphoSitePlus
Y1946GSFDHyAT___PhosphoSitePlus
S1431IAYDHsRVILQY_phosphatasePhosphoSitePlus
T1720MPYEStRVCLQY_phosphatasePhosphoSitePlus
Y1717VNIMPyESTRVY_phosphatasePhosphoSitePlus
Y1428ANVIAyDHSRVY_phosphatasePhosphoSitePlus
Y556ESIIKyELLFRfn3PhosphoSitePlus
T880STPLAtLEFPPfn3PhosphoSitePlus
T813TVAAYtMKGDGfn3PhosphoSitePlus
Y812ITVAAyTMKGDfn3PhosphoSitePlus
Y1793EKCHQyWPAERY_phosphatasePhosphoSitePlus
T1826REFKVtDARDGY_phosphatasePhosphoSitePlus
S708GPGPEsSPVVVfn3PhosphoSitePlus
S387GLSPNsEYEIWHPRD
S396GLSPNsEYEIWHPRD
T891SEDRYtASGVHfn3PhosphoSitePlus
S1484VWEQRsATIVMY_phosphatasePhosphoSitePlus

Dephosphorylation site
PTPRS_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000349932P511LCOSMICMelanoma19074898
ENSP00000349932A157VCOSMICMelanoma19074898
ENSP00000349932R188*COSMICOvarian Cancer21720365
ENSP00000349932P287LCOSMICMelanoma19074898
ENSP00000349932N181KCOSMICMelanoma19074898
ENSP00000349932P141SCOSMICMelanoma19074898
ENSP00000349932D1389NCOSMICMelanoma19074898
ENSP00000349932P1467SCOSMICCentral Nervous System Neoplasms18772396
ENSP00000269907T974MBIOMARTColorectal Cancer21930507, 21930502
ENSP00000349932P1809SCOSMICMelanoma19074898
ENSP00000349932T1553KCOSMICSkin Cancer21984974
ENSP00000349932T996MHPIColorectal Cancer16959974
ENSP00000349932G1514VCOSMICOvarian Cancer21720365
ENSP00000349932V224MCOSMICIntestines Cancer17932254
ENSP00000269907T974MSjoblom2006Intestines Cancer16959974, 21930507, 21930502
ENSP00000349932E1511KCOSMICMelanoma19074898
ENSP00000349932E415KCOSMICHead and Neck Cancer21798893
ENSP00000349932P1920TCOSMICSkin Cancer21984974
ENSP00000327313P1020SBIOMARTNeoplasms by Histologic Type21930507, 21930502
ENSP00000327313T563MBIOMARTPancreatic Cancer21930507, 21930502
ENSP00000349932T996ACOSMICOvarian Cancer21720365

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000349932Prostate CancerTreatment (androgen-starved vs. androgen-stimulated)cell lineUp214729644

Hyperphosphorylation site
PTPRS_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
PGBM_HUMANPTPRS_HUMANligand -> receptorHPMR

Function Annotation
KEGG Pathway
PTPRS_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0004725protein tyrosine phosphatase activityIEAmolecular_function
GO:0021766hippocampus developmentIEAbiological_process
GO:0016311dephosphorylationIEAbiological_process
GO:0005001transmembrane receptor protein tyrosine phosphatasTASmolecular_function
GO:0007155cell adhesionIEAbiological_process
GO:0016791phosphatase activityIEAmolecular_function
GO:0021510spinal cord developmentIEAbiological_process
GO:0021549cerebellum developmentIEAbiological_process
GO:0006470protein dephosphorylationIEAbiological_process
GO:0022038corpus callosum developmentIEAbiological_process
GO:0021987cerebral cortex developmentIEAbiological_process
GO:0005887integral to plasma membraneTAScellular_component
GO:0005515protein bindingIPImolecular_function