| UniProt/SwissProt ID: | PGBM_HUMAN |
| Description: | heparan sulfate proteoglycan 2 [Source:HGNC Symbol;Acc:5273] |
| Location: | chr1 p36.12 |
| Node attribute: | ligand |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S2964 | YKRGGsLPARH | ig | PhosphoSitePlus |
| S2191 | HKRGGsLPARH | ig | PhosphoSitePlus |
| S3783 | PVNGTsQGKFQ | Laminin_G_2 | PhosphoSitePlus |
| T2843 | VAEGQtLDLKC | HPRD | |
| S1345 | TRHLIsTHFAP | PhosphoSitePlus | |
| T3782 | APVNGtSQGKF | Laminin_G_2 | PhosphoSitePlus |
| T2843 | VAEGQtLDLKC | I-set | PhosphoSitePlus |
| S888 | GSMGTsGEACR | PhosphoSitePlus | |
| S3151 | WTRISsTPAKL | I-set | PhosphoSitePlus |
| T887 | RGSMGtSGEAC | PhosphoSitePlus | |
| S2476 | HKRGGsLPARH | I-set | PhosphoSitePlus |
| Y477 | SDQGAyTCEAM | HPRD | |
| T3767 | LLRSLtQGSLI | Laminin_G_2 | PhosphoSitePlus |
| T478 | DQGAYtCEAMN | HPRD | |
| Y1802 | SKSPAyTLVWT | V-set | PhosphoSitePlus |
| T3262 | RLEGDtLIIPR | I-set | PhosphoSitePlus |
| T2063 | SSPSVtEGQTL | I-set | PhosphoSitePlus |
| T1790 | PGADVtFICTA | V-set | PhosphoSitePlus |
| T556 | KGVNVtMPAQP | PhosphoSitePlus | |
| T1816 | NGKLPtRAMDF | V-set | PhosphoSitePlus |
| T563 | PAQPGtPPLSS | PhosphoSitePlus | |
| S472 | RDVKEsDQGAY | HPRD | |
| S2061 | ESSSPsVTEGQ | I-set | PhosphoSitePlus |
| S2486 | HQVHGsRLRLL | I-set | PhosphoSitePlus |
| T3714 | VPGSPtNLANR | Laminin_G_2 | PhosphoSitePlus |
| S2284 | YKRGGsLPARH | I-set | PhosphoSitePlus |
| T1346 | RHLIStHFAPG | PhosphoSitePlus | |
| S3040 | QGQDAsFKCLI | I-set | PhosphoSitePlus |
| T1794 | VTFICtAKSKS | V-set | PhosphoSitePlus |
| S884 | CDERGsMGTSG | PhosphoSitePlus | |
| S2057 | PVKIEsSSPSV | I-set | PhosphoSitePlus |
| Y620 | RYNVRyELARG | Laminin_B | PhosphoSitePlus |
| Y616 | GGSLRyNVRYE | Laminin_B | PhosphoSitePlus |
| Dephosphorylation site |
| PGBM_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000363827 | Q1062K | COSMIC | Ovarian Cancer | 21720365 | ENSP00000363827 | D2263N | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000363827 | Q2951E | COSMIC | Ovarian Cancer | 21720365 | ENSP00000363827 | P1872L | COSMIC | Intestines Cancer | 17932254 | ENSP00000363827 | R3732K | COSMIC | Ovarian Cancer | 21720365 | ENSP00000363827 | T3006I | COSMIC | Ovarian Cancer | 21720365 | ENSP00000363827 | M804V | COSMIC | Ovarian Cancer | 21720365 | ENSP00000363827 | P322L | COSMIC | Melanoma | 21499247 | ENSP00000363827 | P756L | COSMIC | Skin Cancer | 21984974 | ENSP00000363827 | N439Y | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000363827 | G2355A | COSMIC | Ovarian Cancer | 21720365 | ENSP00000363827 | S3488L | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000363827 | S33P | COSMIC | Ovarian Cancer | 21720365 |
| Differential expressed protein |
| Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
|---|---|---|---|---|---|---|
| ENSP00000363827 | hepatitis C virus | Normal vs. Cancer | tissue | Up | 3.3 | 18715028 | ENSP00000363827 | Breast Cancer | Normal vs. Cancer | tissue | Down | 0.99 | 20739354 | ENSP00000363827 | Breast Cancer | Normal vs. Cancer | tissue | Down | 0.99 | 20739354 | ENSP00000363827 | Renal Cancer | Normal vs. Cancer | tissue | Down | 19164279 | ENSP00000363827 | Testicular Cancer | Normal vs. Cancer | cell line | Up | 18489135 | ENSP00000363827 | Pancreatic Cancer | Normal vs. Cancer | tissue | Up | 1.7 | 19199705 |
| Hyperphosphorylation site |
| PGBM_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| PGBM_HUMAN | PTPRS_HUMAN | ligand -> receptor | HPMR |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04512 | ECM-receptor interaction |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0005975 | carbohydrate metabolic process | TAS | biological_process |
| GO:0005578 | proteinaceous extracellular matrix | IEA | cellular_component |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0005509 | calcium ion binding | IEA | molecular_function |
| GO:0048704 | embryonic skeletal system morphogenesis | IEA | biological_process |
| GO:0005886 | plasma membrane | TAS | cellular_component |
| GO:0031012 | extracellular matrix | IEA | cellular_component |
| GO:0005615 | extracellular space | IDA | cellular_component |
| GO:0005605 | basal lamina | IEA | cellular_component |
| GO:0070062 | extracellular vesicular exosome | IDA | cellular_component |
| GO:0002062 | chondrocyte differentiation | IEA | biological_process |
| GO:0030203 | glycosaminoglycan metabolic process | TAS | biological_process |
| GO:0030204 | chondroitin sulfate metabolic process | TAS | biological_process |
| GO:0008104 | protein localization | IEA | biological_process |
| GO:0046872 | metal ion binding | IEA | molecular_function |
| GO:0006024 | glycosaminoglycan biosynthetic process | TAS | biological_process |
| GO:0005796 | Golgi lumen | TAS | cellular_component |
| GO:0007420 | brain development | IEA | biological_process |
| GO:0030198 | extracellular matrix organization | IEA | biological_process |
| GO:0006629 | lipid metabolic process | TAS | biological_process |
| GO:0005576 | extracellular region | TAS | cellular_component |
| GO:0005604 | basement membrane | IEA | cellular_component |
| GO:0031012 | extracellular matrix | IDA | cellular_component |
| GO:0001958 | endochondral ossification | IEA | biological_process |
| GO:0048738 | cardiac muscle tissue development | IEA | biological_process |
| GO:0008022 | protein C-terminus binding | IPI | molecular_function |
| GO:0060351 | cartilage development involved in endochondral bon | IEA | biological_process |
| GO:0043202 | lysosomal lumen | TAS | cellular_component |
| GO:0001525 | angiogenesis | IEA | biological_process |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0042157 | lipoprotein metabolic process | TAS | biological_process |
| GO:0044281 | small molecule metabolic process | TAS | biological_process |
| GO:0006027 | glycosaminoglycan catabolic process | TAS | biological_process |