Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:PTPRJ_HUMAN
Description:protein tyrosine phosphatase, receptor type, J [Source:HGNC Symbol;Acc:9673]
Location:chr11 p11.2
Node attribute:phosphotase

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y1099YINANyMPGYHY_phosphatasePhosphoSitePlus
Y1103NYMPGyHSKKDY_phosphatasePhosphoSitePlus
S1009KNNEVsFSQIKPhosphoSitePlus; HPRD
Y1225YLVRDyMKQSPY_phosphatasePhosphoSitePlus
S1011NEVSFsQIKPKPhosphoSitePlus; HPRD
Y1320TAMTIyENLAPPhosphoSitePlus
T1201RQFHFtSWPDHHPRD
S1105MPGYHsKKDFIY_phosphatasePhosphoSitePlus
T1314LIYQNtTAMTIPhosphoSitePlus
Y1077NNVLPyDISRVY_phosphatasePhosphoSitePlus
Y1311KVDLIyQNTTAPhosphoSitePlus
Y1071RGKNRyNNVLPY_phosphatasePhosphoSitePlus
Y1094HSTDDyINANYY_phosphatasePhosphoSitePlus
T1091VQTHStDDYINY_phosphatasePhosphoSitePlus

Dephosphorylation site
PTPRJ_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000400010P719SCOSMICMelanoma19074898
ENSP00000400010P608ABIOMARTGastric Cancer21930507, 21930502
ENSP00000400010K1017NCOSMICBreast Cancer20393555
ENSP00000400010S1305LCOSMICRenal Cancer
ENSP00000400010Y871FCOSMICHead and Neck Cancer21798893
ENSP00000409733G338STCGAOvarian Cancer21720365, 18772890
ENSP00000400010P521LCOSMICMelanoma19074898
ENSP00000400010A930VCOSMICRenal Cancer20054297
ENSP00000400010R214COMIM, HPIColorectal Cancer12089527
ENSP00000400010P540LCOSMICSkin Cancer21984974
ENSP00000400010G338SCOSMICOvarian Cancer21720365
ENSP00000400010Q276POMIM, HPIColorectal Cancer12089527, 12089527 15378013 20823296 19672627 16258161 15378013 15384144
ENSP00000400010V372LCOSMICRenal Cancer20054297

Differential expressed protein
PTPRJ_HUMAN is not differential expressed protein.

Hyperphosphorylation site
PTPRJ_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
PTPRJ_HUMANPLCG1_HUMANphosphatase -> substrateNetPath
PTPRJ_HUMANSLTM_HUMANphosphatase -> substrateHPRD
PTPRJ_HUMANLAT_HUMANphosphatase -> substrateNetPath
PTPRJ_HUMANPGFRB_HUMANphosphatase -> substrateHPRD

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04520Adherens junction

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0050860negative regulation of T cell receptor signaling pIMPbiological_process
GO:0051898negative regulation of protein kinase B signaling IMPbiological_process
GO:0001954positive regulation of cell-matrix adhesionIEAbiological_process
GO:0008285negative regulation of cell proliferationIDAbiological_process
GO:0001570vasculogenesisIEAbiological_process
GO:0048008platelet-derived growth factor receptor signaling IMPbiological_process
GO:0030336negative regulation of cell migrationIEAbiological_process
GO:0001772immunological synapseIDAcellular_component
GO:0007507heart developmentIEAbiological_process
GO:0005886plasma membraneIEAcellular_component
GO:0060242contact inhibitionNASbiological_process
GO:0042059negative regulation of epidermal growth factor recIMPbiological_process
GO:0004725protein tyrosine phosphatase activityIDAmolecular_function
GO:0016311dephosphorylationIEAbiological_process
GO:0045785positive regulation of cell adhesionIMPbiological_process
GO:0005886plasma membraneIDAcellular_component
GO:0005161platelet-derived growth factor receptor bindingIPImolecular_function
GO:0051894positive regulation of focal adhesion assemblyIMPbiological_process
GO:0045295gamma-catenin bindingIPImolecular_function
GO:0005515protein bindingIPImolecular_function
GO:0019901protein kinase bindingIPImolecular_function
GO:0043407negative regulation of MAP kinase activityIEAbiological_process
GO:0043407negative regulation of MAP kinase activityIDAbiological_process
GO:0010759positive regulation of macrophage chemotaxisIEAbiological_process
GO:0043116negative regulation of vascular permeabilityIDAbiological_process
GO:0035335peptidyl-tyrosine dephosphorylationIDAbiological_process
GO:0007596blood coagulationIEAbiological_process
GO:0005887integral to plasma membraneTAScellular_component
GO:0010572positive regulation of platelet activationIEAbiological_process
GO:0050918positive chemotaxisIDAbiological_process
GO:0009986cell surfaceIDAcellular_component
GO:0030336negative regulation of cell migrationIDAbiological_process
GO:0010642negative regulation of platelet-derived growth facIEAbiological_process
GO:0008285negative regulation of cell proliferationIEAbiological_process
GO:0051897positive regulation of protein kinase B signaling IMPbiological_process
GO:0008013beta-catenin bindingIPImolecular_function
GO:0030155regulation of cell adhesionIMPbiological_process
GO:0006470protein dephosphorylationIEAbiological_process
GO:0032587ruffle membraneIEAcellular_component
GO:0035335peptidyl-tyrosine dephosphorylationIEAbiological_process
GO:0051019mitogen-activated protein kinase bindingIPImolecular_function
GO:0005911cell-cell junctionIDAcellular_component
GO:0070097delta-catenin bindingIPImolecular_function
GO:0010642negative regulation of platelet-derived growth facIDAbiological_process
GO:0050860negative regulation of T cell receptor signaling pIEAbiological_process
GO:0016791phosphatase activityIMPmolecular_function
GO:0030308negative regulation of cell growthIDAbiological_process
GO:2000272negative regulation of receptor activityIEAbiological_process
GO:0001772immunological synapseIEAcellular_component