| UniProt/SwissProt ID: | PTPRH_HUMAN |
| Description: | protein tyrosine phosphatase, receptor type, H [Source:HGNC Symbol;Acc:9672] |
| Location: | chr19 q13.42 |
| Node attribute: | phosphotase |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| T522 | MTDPRtQSTSG | fn3 | PhosphoSitePlus |
| Y1102 | VENLIyENVAA | PhosphoSitePlus | |
| Y1069 | QTEAQyVFLHQ | Y_phosphatase | PhosphoSitePlus |
| T1065 | PLMVQtEAQYV | Y_phosphatase | PhosphoSitePlus |
| S1058 | RKMREsRPLMV | Y_phosphatase | PhosphoSitePlus |
| Dephosphorylation site |
| PTPRH_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000365528 | H1111Q | COSMIC | Head and Neck Cancer | 21798893 | ENSP00000365528 | S365F | COSMIC | Melanoma | 19074898 | ENSP00000365528 | G153E | COSMIC | Melanoma | 19074898 | ENSP00000365528 | P990L | COSMIC | Melanoma | 19074898 | ENSP00000365528 | Q1074* | COSMIC | Melanoma | 19074898 | ENSP00000365528 | S58L | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000365528 | G144D | COSMIC | Melanoma | 19074898 | ENSP00000365528 | A492V | COSMIC | Skin Cancer | 21984974 | ENSP00000365528 | P588S | COSMIC | Skin Cancer | 21984974 | ENSP00000365528 | T168I | COSMIC | Intestines Cancer | 17932254 | ENSP00000365528 | A403S | COSMIC | Ovarian Cancer | 21720365 |
| Differential expressed protein |
| Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
|---|---|---|---|---|---|---|
| ENSP00000365528 | Hepatocellular Carcinoma | Cancer vs. Cancer (HCC vs. HuCCA) | cell line | Up | 20069059 | |
| Hyperphosphorylation site |
| PTPRH_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| PTPRH_HUMAN | LCK_HUMAN | phosphatase -> substrate | NetPath |
| Function Annotation |
| KEGG Pathway |
| PTPRH_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0016311 | dephosphorylation | IEA | biological_process |
| GO:0005001 | transmembrane receptor protein tyrosine phosphatas | TAS | molecular_function |
| GO:0004725 | protein tyrosine phosphatase activity | IEA | molecular_function |
| GO:0005737 | cytoplasm | IDA | cellular_component |
| GO:0006915 | apoptotic process | IEA | biological_process |
| GO:0006470 | protein dephosphorylation | TAS | biological_process |
| GO:0005739 | mitochondrion | IDA | cellular_component |
| GO:0016791 | phosphatase activity | IEA | molecular_function |
| GO:0005634 | nucleus | IDA | cellular_component |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0005887 | integral to plasma membrane | TAS | cellular_component |