| UniProt/SwissProt ID: | PTN_HUMAN |
| Description: | pleiotrophin [Source:HGNC Symbol;Acc:9630] |
| Location: | chr7 q33 |
| Node attribute: | ligand |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| T134 | AECQKtVTISK | PTN_MK_C | PhosphoSitePlus |
| T113 | ECDLNtALKTR | PTN_MK_C | PhosphoSitePlus |
| Y101 | GAECKyQFQAW | PTN_MK_C | PhosphoSitePlus |
| Dephosphorylation site |
| PTN_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000341170 | A97V | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000341170 | E75Q | COSMIC | Head and Neck Cancer | 21798897 | ENSP00000341170 | K40I | COSMIC | Skin Cancer | 21984974 |
| Differential expressed protein |
| PTN_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| PTN_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| PTN_HUMAN | PTPRZ_HUMAN | ligand -> receptor | HPMR |
| Function Annotation |
| KEGG Pathway |
| PTN_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0004864 | protein phosphatase inhibitor activity | TAS | molecular_function |
| GO:0007399 | nervous system development | TAS | biological_process |
| GO:0005783 | endoplasmic reticulum | IDA | cellular_component |
| GO:0030282 | bone mineralization | IEA | biological_process |
| GO:0001503 | ossification | IEA | biological_process |
| GO:0051781 | positive regulation of cell division | IEA | biological_process |
| GO:0007185 | transmembrane receptor protein tyrosine phosphatas | TAS | biological_process |
| GO:0008201 | heparin binding | IEA | molecular_function |
| GO:0005615 | extracellular space | TAS | cellular_component |
| GO:0008083 | growth factor activity | IEA | molecular_function |
| GO:0007612 | learning | IEA | biological_process |
| GO:0008284 | positive regulation of cell proliferation | TAS | biological_process |