| UniProt/SwissProt ID: | PTC2_HUMAN |
| Description: | patched 2 [Source:HGNC Symbol;Acc:9586] |
| Location: | chr1 p34.1 |
| Node attribute: | receptor |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| T15 | LPPSYtPPART | PhosphoSitePlus | |
| T2 | ____MtRSPPL | PhosphoSitePlus | |
| T775 | LPPPAtQAPRT | Patched | PhosphoSitePlus |
| S1152 | SSLPQsFARVT | HPRD | |
| S1194 | SSGNLsSRGPG | PhosphoSitePlus | |
| T1157 | SFARVtTSMTV | HPRD | |
| S4 | __MTRsPPLRE | PhosphoSitePlus | |
| Dephosphorylation site |
| PTC2_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000361266 | Q24H | Ding2008, COSMIC | Lung Cancer | 18948947 | ENSP00000361266 | P853L | COSMIC | Melanoma | 21499247 | ENSP00000361266 | A677V | COSMIC | Central Nervous System Neoplasms | 18772396 | ENSP00000361266 | W293S | COSMIC | Breast Cancer | 20393555 | ENSP00000361266 | W193L | COSMIC | Lung Cancer | 20668451 | ENSP00000361266 | K158* | COSMIC | Ovarian Cancer | 21720365 | ENSP00000361266 | R92P | COSMIC | Breast Cancer | 20668451 | ENSP00000361266 | D1082Y | Ding2008, COSMIC | Lung Cancer | 18948947 | ENSP00000361266 | A68fs*4 | COSMIC | Lung Cancer | ENSP00000361266 | E738K | COSMIC | Breast Cancer | 20668451 | ENSP00000361266 | P1117L | COSMIC | Breast Cancer | 20668451 | ENSP00000361266 | G171A | BIOMART | Pancreatic Cancer | 21930507, 21930502 | ENSP00000361266 | L403M | COSMIC | Lung Cancer | 20668451 |
| Differential expressed protein |
| PTC2_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| PTC2_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| DHH_HUMAN | PTC2_HUMAN | ligand -> receptor | HPMR |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa05217 | Basal cell carcinoma |
| hsa05200 | Pathways in cancer |
| hsa04340 | Hedgehog signaling pathway |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0045879 | negative regulation of smoothened signaling pathwa | TAS | biological_process |
| GO:0008158 | hedgehog receptor activity | TAS | molecular_function |
| GO:0043588 | skin development | IEA | biological_process |
| GO:0005119 | smoothened binding | IPI | molecular_function |
| GO:0097108 | hedgehog family protein binding | TAS | molecular_function |
| GO:0016021 | integral to membrane | IEA | cellular_component |
| GO:0042633 | hair cycle | IEA | biological_process |
| GO:0008544 | epidermis development | IEA | biological_process |
| GO:0016020 | membrane | IEA | cellular_component |