Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:PRP4_HUMAN
Description:PRP4 pre-mRNA processing factor 4 homolog (yeast) [Source:HGNC Symbol;Acc:17349]
Location:chr9 q32
Node attribute:kinase

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y31KKPHIyYGSLEPhosphoSitePlus
S483THPGWsPLKTLWD40PhosphoSitePlus
S483THPGWsPLKTLHPRD
Y32KPHIYyGSLEEPhosphoSitePlus

Dephosphorylation site
PRP4_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000363313G125SCOSMICPancreatic Cancer21252315
ENSP00000363315L487QTCGAOvarian Cancer21720365, 18772890
ENSP00000363315V139ITCGAOvarian Cancer21720365, 18772890
ENSP00000363313V140ICOSMICOvarian Cancer21720365
ENSP00000363313L488QCOSMICOvarian Cancer21720365

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000363313Gastric CancerMetastasiscell lineDown0.6917022644
ENSP00000363313Gastric CancerMetastasiscell lineDown0.6917022644
ENSP00000363313Testicular CancerNormal vs. Cancercell lineUp18489135

Hyperphosphorylation site
PRP4_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
PRP4_HUMANELK1_HUMANkinase -> substrateRegPhos

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa03040Spliceosome

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0008380RNA splicingNASbiological_process
GO:0005654nucleoplasmTAScellular_component
GO:0000398mRNA splicing, via spliceosomeICbiological_process
GO:0006396RNA processingTASbiological_process
GO:0005681spliceosomal complexNAScellular_component
GO:0071001U4/U6 snRNPIDAcellular_component
GO:0015030Cajal bodyIDAcellular_component
GO:0016607nuclear speckIEAcellular_component
GO:0000375RNA splicing, via transesterification reactionsNASbiological_process
GO:0005634nucleusIDAcellular_component
GO:0005515protein bindingIPImolecular_function
GO:0010467gene expressionTASbiological_process


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