| UniProt/SwissProt ID: | PRP4_HUMAN |
| Description: | PRP4 pre-mRNA processing factor 4 homolog (yeast) [Source:HGNC Symbol;Acc:17349] |
| Location: | chr9 q32 |
| Node attribute: | kinase |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| Y31 | KKPHIyYGSLE | PhosphoSitePlus | |
| S483 | THPGWsPLKTL | WD40 | PhosphoSitePlus |
| S483 | THPGWsPLKTL | HPRD | |
| Y32 | KPHIYyGSLEE | PhosphoSitePlus | |
| Dephosphorylation site |
| PRP4_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000363313 | G125S | COSMIC | Pancreatic Cancer | 21252315 | ENSP00000363315 | L487Q | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000363315 | V139I | TCGA | Ovarian Cancer | 21720365, 18772890 | ENSP00000363313 | V140I | COSMIC | Ovarian Cancer | 21720365 | ENSP00000363313 | L488Q | COSMIC | Ovarian Cancer | 21720365 |
| Differential expressed protein |
| Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
|---|---|---|---|---|---|---|
| ENSP00000363313 | Gastric Cancer | Metastasis | cell line | Down | 0.69 | 17022644 | ENSP00000363313 | Gastric Cancer | Metastasis | cell line | Down | 0.69 | 17022644 | ENSP00000363313 | Testicular Cancer | Normal vs. Cancer | cell line | Up | 18489135 |
| Hyperphosphorylation site |
| PRP4_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| PRP4_HUMAN | ELK1_HUMAN | kinase -> substrate | RegPhos |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa03040 | Spliceosome |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0008380 | RNA splicing | NAS | biological_process |
| GO:0005654 | nucleoplasm | TAS | cellular_component |
| GO:0000398 | mRNA splicing, via spliceosome | IC | biological_process |
| GO:0006396 | RNA processing | TAS | biological_process |
| GO:0005681 | spliceosomal complex | NAS | cellular_component |
| GO:0071001 | U4/U6 snRNP | IDA | cellular_component |
| GO:0015030 | Cajal body | IDA | cellular_component |
| GO:0016607 | nuclear speck | IEA | cellular_component |
| GO:0000375 | RNA splicing, via transesterification reactions | NAS | biological_process |
| GO:0005634 | nucleus | IDA | cellular_component |
| GO:0005515 | protein binding | IPI | molecular_function |
| GO:0010467 | gene expression | TAS | biological_process |