Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:PRKN2_HUMAN
Description:parkinson protein 2, E3 ubiquitin protein ligase (parkin) [Source:HGNC Symbol;Acc:8607]
Location:chr6 q26
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y372ECKEAyHEGECIBRPhosphoSitePlus
S108TRVDLsSSVLPPhosphoSitePlus
S378HEGECsAVFEAIBRPhosphoSitePlus
S9FVRFNsSHGFPubiquitinPhosphoSitePlus
S19PVEVDsDTSIFubiquitinPhosphoSitePlus
T388ASGTTtQAYRVPhosphoSitePlus
S101EREPQsLTRVDCK1a(CK1 alphaRegPhos
S378HEGECsAVFEACK1_alphaphosphoELM
Y143AGRSIyNSFYVPhosphoSitePlus
S116VLPGDsVGLAVPhosphoSitePlus
S136SPPAGsPAGRSPhosphoSitePlus; phosphoELM; RegPhos
S65DLDQQsIVHIVubiquitinPhosphoSitePlus
S296AGCPNsLIKELPhosphoSitePlus; phosphoELM; RegPhos
S378HEGECsAVFEACK1a(CK1 alphaRegPhos
S101EREPQsLTRVDPhosphoSitePlus
S131DSRKDsPPAGSPhosphoSitePlus; phosphoELM; RegPhos
S101EREPQsLTRVDCK1_alphaphosphoELM

Dephosphorylation site
PRKN2_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000355865P88LCOSMICSkin Cancer21984974
ENSP00000355865T240MCOSMICHead and Neck Cancer21798897

Differential expressed protein
PRKN2_HUMAN is not differential expressed protein.

Hyperphosphorylation site
SiteMotifPeptideCancer namePubmedSource
S131HTDSRKDsPPAGSPAParkinson's disease17327227PhosphoSitePlus
Y143SPAGRSIyNSFYVYCParkinson's disease20823226PhosphoSitePlus

Direct Interaction Pair
SourceTargetRelationshipResource
ZAGL2_HUMANPRKN2_HUMANkinase -> substrateRegPhos
KC1A_HUMANPRKN2_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04120Ubiquitin mediated proteolysis
hsa05012Parkinson's disease
hsa04141Protein processing in endoplasmic reticulum

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0019901protein kinase bindingIPImolecular_function
GO:0005739mitochondrionIMPcellular_component
GO:0043524negative regulation of neuron apoptotic processIDAbiological_process
GO:0016881acid-amino acid ligase activityIEAmolecular_function
GO:0005515protein bindingIPImolecular_function
GO:0019900kinase bindingIPImolecular_function
GO:0006511ubiquitin-dependent protein catabolic processIDAbiological_process
GO:0070997neuron deathIDAbiological_process
GO:0007417central nervous system developmentTASbiological_process
GO:0030165PDZ domain bindingIPImolecular_function
GO:0090201negative regulation of release of cytochrome c froIDAbiological_process
GO:0008270zinc ion bindingIEAmolecular_function
GO:0070936protein K48-linked ubiquitinationIDAbiological_process
GO:0016235aggresomeIDAcellular_component
GO:0006513protein monoubiquitinationIDAbiological_process
GO:0070842aggresome assemblyIMPbiological_process
GO:0005829cytosolIDAcellular_component
GO:0070534protein K63-linked ubiquitinationIDAbiological_process
GO:0005794Golgi apparatusIDAcellular_component
GO:0060548negative regulation of cell deathIDAbiological_process
GO:0005634nucleusIEAcellular_component
GO:0005783endoplasmic reticulumIEAcellular_component
GO:0032232negative regulation of actin filament bundle assemIDAbiological_process
GO:0000422mitochondrion degradationIMPbiological_process
GO:0008219cell deathIDAbiological_process
GO:0048471perinuclear region of cytoplasmIDAcellular_component
GO:2000377regulation of reactive oxygen species metabolic prIMPbiological_process
GO:0051865protein autoubiquitinationIDAbiological_process
GO:0001933negative regulation of protein phosphorylationIDAbiological_process
GO:0031625ubiquitin protein ligase bindingIPImolecular_function
GO:0042787protein ubiquitination involved in ubiquitin-depenIDAbiological_process
GO:0043123positive regulation of I-kappaB kinase/NF-kappaB cIDAbiological_process
GO:0051087chaperone bindingIPImolecular_function
GO:0005737cytoplasmIDAcellular_component
GO:0010506regulation of autophagyIDAbiological_process
GO:0004842ubiquitin-protein ligase activityIDAmolecular_function
GO:0000209protein polyubiquitinationIDAbiological_process


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