Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:PRGC2_HUMAN
Description:peroxisome proliferator-activated receptor gamma, coactivator 1 beta [Source:HGNC Symbol;Acc:30022]
Location:chr5 q32
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S854CSRSRsSSGSSPhosphoSitePlus
S992YTDYDsNSEEAPhosphoSitePlus
Y990PRYTDyDSNSEPhosphoSitePlus
Y987FCWPRyTDYDSPhosphoSitePlus
S570LPPRDsPRCLMAKT1HPRD
S711RKVLRsWEPSGPhosphoSitePlus
T947KYGFItYRCSERRM_1PhosphoSitePlus
Y948YGFITyRCSEHRRM_1PhosphoSitePlus
S524ERELGsPTDEDPhosphoSitePlus; HPRD; phosphoELM
Y943RRGEKyGFITYRRM_1PhosphoSitePlus

Dephosphorylation site
PRGC2_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000377855E69QBIOMARTBreast Cancer21930507, 21930502
ENSP00000312649D51ECOSMICOvarian Cancer21720365
ENSP00000312649E69QBIOMARTBreast Cancer21930507, 21930502
ENSP00000312649P191LCOSMICOvarian Cancer21720365

Differential expressed protein
PRGC2_HUMAN is not differential expressed protein.

Hyperphosphorylation site
PRGC2_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
AKT1_HUMANPRGC2_HUMANkinase -> substrateHPRD

Function Annotation
KEGG Pathway
PRGC2_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0030520intracellular estrogen receptor signaling pathwayIDAbiological_process
GO:0000166nucleotide bindingIEAmolecular_function
GO:0007015actin filament organizationIEAbiological_process
GO:0001503ossificationIEAbiological_process
GO:0005634nucleusIDAcellular_component
GO:0045893positive regulation of transcription, DNA-dependenIEAbiological_process
GO:0045672positive regulation of osteoclast differentiationIEAbiological_process
GO:0051591response to cAMPIEAbiological_process
GO:0001104RNA polymerase II transcription cofactor activityIDAmolecular_function
GO:0042327positive regulation of phosphorylationIEAbiological_process
GO:0016592mediator complexIDAcellular_component
GO:0005739mitochondrionIEAcellular_component
GO:0003676nucleic acid bindingIEAmolecular_function
GO:0050682AF-2 domain bindingIPImolecular_function
GO:0034614cellular response to reactive oxygen speciesIEAbiological_process
GO:0045892negative regulation of transcription, DNA-dependenIEAbiological_process
GO:0003723RNA bindingNASmolecular_function
GO:0060346bone trabecula formationIEAbiological_process
GO:0045944positive regulation of transcription from RNA polyIDAbiological_process
GO:0030546receptor activator activityIDAmolecular_function
GO:0010694positive regulation of alkaline phosphatase activiIEAbiological_process
GO:0006390transcription from mitochondrial promoterIEAbiological_process
GO:0030374ligand-dependent nuclear receptor transcription coIDAmolecular_function
GO:0051384response to glucocorticoid stimulusIEAbiological_process
GO:0030331estrogen receptor bindingIDAmolecular_function
GO:0005515protein bindingIEAmolecular_function
GO:0045780positive regulation of bone resorptionIEAbiological_process
GO:2000273positive regulation of receptor activityIDAbiological_process


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