Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:PRC1_HUMAN
Description:protein regulator of cytokinesis 1 [Source:HGNC Symbol;Acc:9341]
Location:chr15 q26.1
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T481GLAPNtPGKARphosphoELM; RegPhos; SysPTM
S592SLSDSsTVGLQMAP65_ASE1PhosphoSitePlus; SysPTM
S265VATIMsGSKAKMAP65_ASE1; DUF3700PhosphoSitePlus
Y560ILSGGyPGSAPHPRD
S587FAKDPsLSDSSHPRD
S591PSLSDsSTVGLMAP65_ASE1PhosphoSitePlus
T194DHTPDtSFERDHPRD
T616GILNStNIQS_PhosphoSitePlus
S592SLSDSsTVGLQHPRD; phosphoELM; RegPhos; SysPTM
T593LSDSStVGLQRMAP65_ASE1PhosphoSitePlus
Y464ETEMLyGSAPRMAP65_ASE1PhosphoSitePlus
S472APRTPsKRRGLMAP65_ASE1PhosphoSitePlus
T481GLAPNtPGKARCDK2HPRD; RegPhos; SysPTM
S615SGILNsTNIHPRD
S620STNIHPRD
T536CSGKKtPRTGRHPRD
S554LELNGsILSGGMAP65_ASE1PhosphoSitePlus
S574NFSINsVASTYMAP65_ASE1PhosphoSitePlus
T470GSAPRtPSKRRCDK2HPRD; RegPhos
S195HTPDTsFERDVHPRD; phosphoELM; RegPhos; SysPTM
S589KDPSLsDSSTVHPRD
S466EMLYGsAPRTPMAP65_ASE1PhosphoSitePlus
S589KDPSLsDSSTVMAP65_ASE1PhosphoSitePlus
S195HTPDTsFERDVMAP65_ASE1; DUF3700PhosphoSitePlus; SysPTM
S513GTVYHsPVSRLHPRD; SysPTM
S513GTVYHsPVSRLMAP65_ASE1PhosphoSitePlus; SysPTM
S577INSVAsTYSEFMAP65_ASE1PhosphoSitePlus
S265VATIMsGSKAKHPRD
S587FAKDPsLSDSSMAP65_ASE1PhosphoSitePlus
S615SGILNsTNIQSMAP65_ASE1PhosphoSitePlus
T191EELDHtPDTSFHPRD; SysPTM
T536CSGKKtPRTGRMAP65_ASE1PhosphoSitePlus
Y511FGGTVyHSPVSMAP65_ASE1PhosphoSitePlus
S267TIMSGsKAKVRHPRD
S620STNIQs_____PhosphoSitePlus
S501ATANSsIRPIFHPRD
T262REAVAtIMSGSMAP65_ASE1; DUF3700PhosphoSitePlus
S516YHSPVsRLPPSMAP65_ASE1PhosphoSitePlus
T470GSAPRtPSKRRMAP65_ASE1PhosphoSitePlus
S571LQRNFsINSVAMAP65_ASE1PhosphoSitePlus
T379DPNRFtNRGGNMAP65_ASE1PhosphoSitePlus
T578NSVAStYSEFAMAP65_ASE1PhosphoSitePlus
T481GLAPNtPGKARMAP65_ASE1PhosphoSitePlus; SysPTM

Dephosphorylation site
PRC1_HUMAN do not have dephosphorylation site.

Mutation site
PRC1_HUMAN do not have mutation site.

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000377793Ovarian CancerTreatment (cisplatin-sensitive vs. cisplatin-resistant)cell lineDown0.5116319398

Hyperphosphorylation site
PRC1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
ZAGL2_HUMANPRC1_HUMANkinase -> substrateRegPhos
CDK2_HUMANPRC1_HUMANkinase -> substrateRegPhos

Function Annotation
KEGG Pathway
PRC1_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005819spindleIDAcellular_component
GO:0042802identical protein bindingIPImolecular_function
GO:0005876spindle microtubuleTAScellular_component
GO:0005634nucleusIDAcellular_component
GO:0000910cytokinesisIDAbiological_process
GO:0000922spindle poleIEAcellular_component
GO:0005515protein bindingIPImolecular_function
GO:0008017microtubule bindingIEAmolecular_function
GO:0005737cytoplasmIDAcellular_component
GO:0015630microtubule cytoskeletonIDAcellular_component
GO:0005886plasma membraneIDAcellular_component
GO:0000910cytokinesisIEAbiological_process
GO:0019901protein kinase bindingIPImolecular_function
GO:0000226microtubule cytoskeleton organizationIEAbiological_process
GO:0000022mitotic spindle elongationTASbiological_process


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