Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:PLSL_HUMAN
Description:lymphocyte cytosolic protein 1 (L-plastin) [Source:HGNC Symbol;Acc:6528]
Location:chr13 q14.13
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T353QFVTAtDVVRGCHPhosphoSitePlus
S7ARGSVsDEEMMPKA_groupRegPhos
S5MARGSvSDEEPKACaRegPhos
S30GNGYIsFNELNEF_hand_5PhosphoSitePlus
S117VGTQHsYSEEEPhosphoSitePlus
S5_MARGsVSDEEPhosphoSitePlus
S5SDEEPRKACAHPRD
Y28TDGNGyISFNEHPRD; phosphoELM
S537AKKSSsISSFKHPRD
T54RVREItENLMAEF_hand_5PhosphoSitePlus
S5MARGSvSDEERegPhos
S7ARGSVsDEEMMPhosphoSitePlus; RegPhos
Y430VIFQLyEKIKVCHPhosphoSitePlus
T399TREERtFRNWMCHPhosphoSitePlus
Y28TDGNGyISFNEEF_hand_5PhosphoSitePlus
T351CRQFVtATDVVCHPhosphoSitePlus
S110GTSEQsSVGTQPhosphoSitePlus
Y417RVNHLySDLSDCHPhosphoSitePlus
T114QSSVGtQHSYSPhosphoSitePlus
T89TDVAKtFRKAIPhosphoSitePlus
Y374NLFNRyPALHKCHPhosphoSitePlus
Y299KDSKAyYHLLECHPhosphoSitePlus
Y598IGARVyALPEDCHPhosphoSitePlus
S257LREGEsLEDLMPhosphoSitePlus; HPRD
S474NQAKFsLVGIGCHPhosphoSitePlus
Y48LPLPGyRVREIEF_hand_5PhosphoSitePlus
T291IGNFStDIKDSCHPhosphoSitePlus
Y124SEEEKyAFVNWCHPhosphoSitePlus
T614PKMVMtVFACLCHPhosphoSitePlus
Y124SEEEKyAFVNWHPRD; RegPhos
Y276LRWANyHLENAHPRD; phosphoELM
S7EEMMPKA_groupphosphoELM
S5MARGSvSDEEPKA_groupRegPhos
S323VVIDMsGLREKCHPhosphoSitePlus
S119TQHSYsEEEKYPhosphoSitePlus
S243ADIELsRNEALPhosphoSitePlus; HPRD
Y276LRWANyHLENACHPhosphoSitePlus
Y118GTQHSySEEEKPhosphoSitePlus
S406RNWMNsLGVNPCHPhosphoSitePlus
Y300DSKAYyHLLEQCHPhosphoSitePlus
S5SDEEPKA_groupphosphoELM

Dephosphorylation site
PLSL_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000315757Q109*COSMICLung Cancer20668451
ENSP00000315757N581SCOSMICOvarian Cancer20668451
ENSP00000315757S83TCOSMICSkin Cancer21984974
ENSP00000381581S83TCOSMICSkin Cancer21984974
ENSP00000315757E33DCOSMICLung Cancer20668451
ENSP00000381581L407MCOSMICLung Cancer20668451
ENSP00000381581Q109*COSMICLung Cancer20668451
ENSP00000381581E33DCOSMICLung Cancer20668451
ENSP00000315757L407MCOSMICLung Cancer20668451
ENSP00000381581N581SCOSMICOvarian Cancer20668451

Differential expressed protein
Ensembl IDCancer nameDesignSampleChangeRatioPubmed
ENSP00000315757Uterine CancerNormal vs. CancertissueUp17902640
ENSP00000315757Breast CancerNormal vs. CancertissueUp18257521
ENSP00000315757Breast CancerMetastasistissueDown18257521
ENSP00000315757Neoplasms by Histologic TypeNormal vs. CancertissueDown0.6918259946
ENSP00000315757Neoplasms by Histologic TypeNormal vs. CancertissueDown0.212874873
ENSP00000315757chronic myeloid leukemiaTreatment (Imatinib-sensitive vs. Imatinib-resistant)cell lineUp1.820417730
ENSP00000315757Pancreatic CancerNormal vs. CancertissueUp<215526344
ENSP00000315757Gastric CancerNormal vs. CancertissueDown0.3615761955

Hyperphosphorylation site
PLSL_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
ZAGL2_HUMANPLSL_HUMANkinase -> substrateRegPhos
KPCA_HUMANPLSL_HUMANkinase -> substrateHPRD

Function Annotation
KEGG Pathway
PLSL_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0031100organ regenerationIEAbiological_process
GO:0030054cell junctionIEAcellular_component
GO:0015629actin cytoskeletonIDAcellular_component
GO:0005509calcium ion bindingIEAmolecular_function
GO:0005884actin filamentIEAcellular_component
GO:0033157regulation of intracellular protein transportIDAbiological_process
GO:0051015actin filament bindingIEAmolecular_function
GO:0003779actin bindingNASmolecular_function
GO:0005737cytoplasmIEAcellular_component
GO:0005737cytoplasmIDAcellular_component
GO:0002286T cell activation involved in immune responseIDAbiological_process
GO:0001726ruffleIEAcellular_component
GO:0051017actin filament bundle assemblyIEAbiological_process
GO:0001891phagocytic cupIEAcellular_component
GO:0042802identical protein bindingIEAmolecular_function
GO:0032587ruffle membraneIEAcellular_component
GO:0005515protein bindingIEAmolecular_function
GO:0005886plasma membraneIDAcellular_component
GO:0005829cytosolIDAcellular_component


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