| UniProt/SwissProt ID: | PLIN1_HUMAN |
| Description: | perilipin 1 [Source:HGNC Symbol;Acc:9076] |
| Location: | chr15 q26.1 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| Y58 | SVCNAyEKGVQ | Perilipin | PhosphoSitePlus |
| Y401 | DTVVHyVPLPR | PhosphoSitePlus | |
| T301 | EDQTDtEGEDT | Perilipin | PhosphoSitePlus |
| T299 | DHEDQtDTEGE | Perilipin | PhosphoSitePlus |
| S81 | VVRRLsTQFTA | Perilipin | PhosphoSitePlus |
| S384 | RAMSLsDALKG | Perilipin | PhosphoSitePlus |
| S53 | HPLVAsVCNAY | Perilipin | PhosphoSitePlus |
| T40 | ECFQKtYTSTK | Perilipin | PhosphoSitePlus |
| S81 | VVRRLsTQFTA | PRKACA | HPRD |
| S382 | KGRAMsLSDAL | Perilipin | PhosphoSitePlus |
| T306 | TEGEDtEEEEE | Perilipin | PhosphoSitePlus |
| Y515 | LGRTHySQLRK | PhosphoSitePlus | |
| Dephosphorylation site |
| PLIN1_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000300055 | L191R | COSMIC | Melanoma | 20016485 | ENSP00000300055 | E162K | COSMIC | Skin Cancer | 21984974 |
| Differential expressed protein |
| Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
|---|---|---|---|---|---|---|
| ENSP00000402167 | Breast Cancer | Metastasis | tissue | Down | 0.41 | 19053527 | ENSP00000402167 | Breast Cancer | Metastasis | tissue | Down | 0.42 | 19053527 |
| Hyperphosphorylation site |
| PLIN1_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| KPCA_HUMAN | PLIN1_HUMAN | kinase -> substrate | HPRD |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa03320 | PPAR signaling pathway |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0019433 | triglyceride catabolic process | TAS | biological_process |
| GO:0044281 | small molecule metabolic process | TAS | biological_process |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0006629 | lipid metabolic process | NAS | biological_process |
| GO:0008289 | lipid binding | NAS | molecular_function |
| GO:0016042 | lipid catabolic process | IEA | biological_process |
| GO:0005811 | lipid particle | NAS | cellular_component |