Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:PLEK_HUMAN
Description:pleckstrin [Source:HGNC Symbol;Acc:9070]
Location:chr2 p14
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T114FARKStRRSIRPhosphoSitePlus; HPRD; RegPhos
S183LMIASsLLNEGHPRD; RegPhos
S117KSTRRsIRLPEPKCa(PKC alphaRegPhos
T123IRLPEtIDLGAPhosphoSitePlus
S117KSTRRsIRLPEPhosphoSitePlus; HPRD; phosphoELM; RegPhos
Y278AYLHYyDPAGAPHPhosphoSitePlus
S132GALYLsMKDTEPhosphoSitePlus
S113KFARKsTRRSIPKC_groupphosphoELM; RegPhos
S113KFARKsTRRSIPhosphoSitePlus; HPRD; phosphoELM; RegPhos
S117KSTRRsIRLPEPKC_groupphosphoELM; RegPhos
S197PAGDMsKSAVDHPRD; RegPhos
S113KFARKsTRRSIPKCa(PKC alphaRegPhos
Y130DLGALyLSMKDHPRD
T136LSMKDtEKGIKPhosphoSitePlus
S113KFARKsTRRSIPKC_alphaphosphoELM
T114FARKStRRSIRPKC_groupphosphoELM; RegPhos
Y277PAYLHyYDPAGPHPhosphoSitePlus
S117KSTRRsIRLPEPKC_alphaphosphoELM

Dephosphorylation site
PLEK_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000234313F224LTCGAOvarian Cancer21720365, 18772890
ENSP00000234313F224LCOSMICOvarian Cancer21720365

Differential expressed protein
PLEK_HUMAN is not differential expressed protein.

Hyperphosphorylation site
PLEK_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
ZAGL2_HUMANPLEK_HUMANkinase -> substrateRegPhos
KPCA_HUMANPLEK_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
PLEK_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005080protein kinase C bindingIDAmolecular_function
GO:0060305regulation of cell diameterIDAbiological_process
GO:0030168platelet activationTASbiological_process
GO:0070527platelet aggregationIEAbiological_process
GO:0035556intracellular signal transductionIEAbiological_process
GO:0032587ruffle membraneIDAcellular_component
GO:0050849negative regulation of calcium-mediated signalingNASbiological_process
GO:0031529ruffle organizationIDAbiological_process
GO:0002576platelet degranulationIEPbiological_process
GO:0010920negative regulation of inositol phosphate biosynthIDAbiological_process
GO:0033625positive regulation of integrin activationISSbiological_process
GO:0007596blood coagulationTASbiological_process
GO:0010925positive regulation of inositol-polyphosphate 5-phIDAbiological_process
GO:0030836positive regulation of actin filament depolymerizaIDAbiological_process
GO:0070493thrombin receptor signaling pathwayIDAbiological_process
GO:0031532actin cytoskeleton reorganizationIDAbiological_process
GO:0006904vesicle docking involved in exocytosisISSbiological_process
GO:0070527platelet aggregationISSbiological_process
GO:0032233positive regulation of actin filament bundle assemIDAbiological_process
GO:0006904vesicle docking involved in exocytosisIEAbiological_process
GO:0030030cell projection organizationIDAbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0070528protein kinase C signaling cascadeIEAbiological_process
GO:0033625positive regulation of integrin activationIEAbiological_process
GO:0002244hematopoietic progenitor cell differentiationIEPbiological_process
GO:0005829cytosolTAScellular_component
GO:0010572positive regulation of platelet activationISSbiological_process
GO:0043325phosphatidylinositol-3,4-bisphosphate bindingIDAmolecular_function
GO:0030866cortical actin cytoskeleton organizationIDAbiological_process
GO:0005576extracellular regionTAScellular_component
GO:0007229integrin-mediated signaling pathwayIDAbiological_process
GO:0005737cytoplasmIDAcellular_component
GO:0070560protein secretion by plateletISSbiological_process
GO:0042803protein homodimerization activityIDAmolecular_function
GO:0010572positive regulation of platelet activationIEAbiological_process
GO:0030845phospholipase C-inhibiting G-protein coupled recepIDAbiological_process
GO:0005543phospholipid bindingIEAmolecular_function
GO:0046488phosphatidylinositol metabolic processIDAbiological_process
GO:0070528protein kinase C signaling cascadeISSbiological_process
GO:0045744negative regulation of G-protein coupled receptor IDAbiological_process
GO:0070560protein secretion by plateletIEAbiological_process