Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:PLCD4_HUMAN
Description:phospholipase C, delta 4 [Source:HGNC Symbol;Acc:9062]
Location:chr2 q35
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S635LIQVIsGQQLPC2PhosphoSitePlus
S56RQARGsAKPSFPHPhosphoSitePlus

Dephosphorylation site
PLCD4_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000388631E525KCOSMICOvarian Cancer21720365
ENSP00000388631S521PTCGAOvarian Cancer21720365, 18772890
ENSP00000396942S494FBIOMARTBreast Cancer21930507, 21930502
ENSP00000396942E525KCOSMICOvarian Cancer21720365
ENSP00000396942K435ETCGAOvarian Cancer21720365, 18772890
ENSP00000388631S494FBIOMARTBreast Cancer21930507, 21930502
ENSP00000388631K435ETCGAOvarian Cancer21720365, 18772890
ENSP00000396942S521PTCGAOvarian Cancer21720365, 18772890
ENSP00000396942K435ECOSMICOvarian Cancer21720365
ENSP00000388631S521PCOSMICOvarian Cancer21720365
ENSP00000388631K435ECOSMICOvarian Cancer21720365
ENSP00000396942S521PCOSMICOvarian Cancer21720365

Differential expressed protein
PLCD4_HUMAN is not differential expressed protein.

Hyperphosphorylation site
PLCD4_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
CDKL5_HUMANPLCD4_HUMANkinase -> substrateRobert H Newman (2013)
KCC1B_HUMANPLCD4_HUMANkinase -> substrateRobert H Newman (2013)
HIPK4_HUMANPLCD4_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
PLCD4_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0007165signal transductionIEAbiological_process
GO:0008081phosphoric diester hydrolase activityIEAmolecular_function
GO:0007340acrosome reactionIEAbiological_process
GO:0035556intracellular signal transductionIEAbiological_process
GO:0006629lipid metabolic processIEAbiological_process
GO:0004435phosphatidylinositol phospholipase C activityIEAmolecular_function
GO:0005634nucleusIEAcellular_component
GO:0005783endoplasmic reticulumIEAcellular_component
GO:0004871signal transducer activityIEAmolecular_function
GO:0016042lipid catabolic processIEAbiological_process
GO:0005622intracellularIEAcellular_component
GO:0016020membraneIEAcellular_component
GO:0005543phospholipid bindingIEAmolecular_function
GO:0005515protein bindingIEAmolecular_function
GO:0005509calcium ion bindingIEAmolecular_function


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