UniProt/SwissProt ID: | PLCD4_HUMAN |
Description: | phospholipase C, delta 4 [Source:HGNC Symbol;Acc:9062] |
Location: | chr2 q35 |
Node attribute: | substrate |
Phosphorylation site |
Position | PhosphoPeptide | Catalytic kinase | Source |
---|---|---|---|
S635 | LIQVIsGQQLP | C2 | PhosphoSitePlus |
S56 | RQARGsAKPSF | PH | PhosphoSitePlus |
Dephosphorylation site |
PLCD4_HUMAN do not have dephosphorylation site. |
Mutation site |
Ensembl ID | Variation | Source | Cancer name | Pubmed |
---|---|---|---|---|
ENSP00000388631 | E525K | COSMIC | Ovarian Cancer | 21720365 |
ENSP00000388631 | S521P | TCGA | Ovarian Cancer | 21720365, 18772890 |
ENSP00000396942 | S494F | BIOMART | Breast Cancer | 21930507, 21930502 |
ENSP00000396942 | E525K | COSMIC | Ovarian Cancer | 21720365 |
ENSP00000396942 | K435E | TCGA | Ovarian Cancer | 21720365, 18772890 |
ENSP00000388631 | S494F | BIOMART | Breast Cancer | 21930507, 21930502 |
ENSP00000388631 | K435E | TCGA | Ovarian Cancer | 21720365, 18772890 |
ENSP00000396942 | S521P | TCGA | Ovarian Cancer | 21720365, 18772890 |
ENSP00000396942 | K435E | COSMIC | Ovarian Cancer | 21720365 |
ENSP00000388631 | S521P | COSMIC | Ovarian Cancer | 21720365 |
ENSP00000388631 | K435E | COSMIC | Ovarian Cancer | 21720365 |
ENSP00000396942 | S521P | COSMIC | Ovarian Cancer | 21720365 |
Differential expressed protein |
PLCD4_HUMAN is not differential expressed protein. |
Hyperphosphorylation site |
PLCD4_HUMAN do not have hyperphosphorylation site. |
Direct Interaction Pair |
Source | Target | Relationship | Resource |
---|---|---|---|
CDKL5_HUMAN | PLCD4_HUMAN | kinase -> substrate | Robert H Newman (2013) |
KCC1B_HUMAN | PLCD4_HUMAN | kinase -> substrate | Robert H Newman (2013) |
HIPK4_HUMAN | PLCD4_HUMAN | kinase -> substrate | Robert H Newman (2013) |
Function Annotation |
KEGG Pathway |
PLCD4_HUMAN is not in KEGG pathway. |
Gene Ontology |
GO ID | GO_Term | Evidence | Ontology |
---|---|---|---|
GO:0007165 | signal transduction | IEA | biological_process |
GO:0008081 | phosphoric diester hydrolase activity | IEA | molecular_function |
GO:0007340 | acrosome reaction | IEA | biological_process |
GO:0035556 | intracellular signal transduction | IEA | biological_process |
GO:0006629 | lipid metabolic process | IEA | biological_process |
GO:0004435 | phosphatidylinositol phospholipase C activity | IEA | molecular_function |
GO:0005634 | nucleus | IEA | cellular_component |
GO:0005783 | endoplasmic reticulum | IEA | cellular_component |
GO:0004871 | signal transducer activity | IEA | molecular_function |
GO:0016042 | lipid catabolic process | IEA | biological_process |
GO:0005622 | intracellular | IEA | cellular_component |
GO:0016020 | membrane | IEA | cellular_component |
GO:0005543 | phospholipid binding | IEA | molecular_function |
GO:0005515 | protein binding | IEA | molecular_function |
GO:0005509 | calcium ion binding | IEA | molecular_function |