| UniProt/SwissProt ID: | PKHA4_HUMAN |
| Description: | pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4 [Source:HGNC Symbol;Acc:14339] |
| Location: | chr19 q13.33 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S313 | GKPPRsPQHWS | PhosphoSitePlus | |
| S241 | LSRPPsPLSLP | PhosphoSitePlus | |
| S8 | GSRPRsSLSLA | PhosphoSitePlus | |
| S4 | __MEGsRPRSS | PhosphoSitePlus | |
| S624 | LGRTLsPARRQ | PhosphoSitePlus | |
| S20 | SASTIsSLSSL | PhosphoSitePlus | |
| S229 | MRRARsPDLFT | PhosphoSitePlus | |
| S552 | DKDLAsPHLGL | PhosphoSitePlus | |
| S21 | ASTISsLSSLS | PhosphoSitePlus | |
| S26 | SLSSLsPKKPT | PhosphoSitePlus | |
| S11 | PRSSLsLASSA | PhosphoSitePlus | |
| Y332 | SGSPTyLQLPP | PhosphoSitePlus | |
| S274 | PHTPLsRIDVR | PhosphoSitePlus | |
| Dephosphorylation site |
| PKHA4_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000263265 | Q169H | COSMIC | Skin Cancer | 21984974 | ENSP00000263265 | G642E | COSMIC | Melanoma | ENSP00000263265 | E445D | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000263265 | G459D | COSMIC | Central Nervous System Neoplasms | 18772396 | ENSP00000347683 | E420D | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000347683 | G447S | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000263265 | G472S | BIOMART | Breast Cancer | 21930507, 21930502 | ENSP00000347683 | R397H | BIOMART | Pancreatic Cancer | 21930507, 21930502 |
| Differential expressed protein |
| PKHA4_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| PKHA4_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| AKT1_HUMAN | PKHA4_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| PKHA4_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0005737 | cytoplasm | IEA | cellular_component |
| GO:0005545 | 1-phosphatidylinositol binding | NAS | molecular_function |
| GO:0005543 | phospholipid binding | IEA | molecular_function |
| GO:0016020 | membrane | IEA | cellular_component |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0008150 | biological_process | ND | biological_process |
| GO:0005575 | cellular_component | ND | cellular_component |