Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:PKHA4_HUMAN
Description:pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4 [Source:HGNC Symbol;Acc:14339]
Location:chr19 q13.33
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S313GKPPRsPQHWSPhosphoSitePlus
S241LSRPPsPLSLPPhosphoSitePlus
S8GSRPRsSLSLAPhosphoSitePlus
S4__MEGsRPRSSPhosphoSitePlus
S624LGRTLsPARRQPhosphoSitePlus
S20SASTIsSLSSLPhosphoSitePlus
S229MRRARsPDLFTPhosphoSitePlus
S552DKDLAsPHLGLPhosphoSitePlus
S21ASTISsLSSLSPhosphoSitePlus
S26SLSSLsPKKPTPhosphoSitePlus
S11PRSSLsLASSAPhosphoSitePlus
Y332SGSPTyLQLPPPhosphoSitePlus
S274PHTPLsRIDVRPhosphoSitePlus

Dephosphorylation site
PKHA4_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000263265Q169HCOSMICSkin Cancer21984974
ENSP00000263265G642ECOSMICMelanoma
ENSP00000263265E445DBIOMARTBreast Cancer21930507, 21930502
ENSP00000263265G459DCOSMICCentral Nervous System Neoplasms18772396
ENSP00000347683E420DBIOMARTBreast Cancer21930507, 21930502
ENSP00000347683G447SBIOMARTBreast Cancer21930507, 21930502
ENSP00000263265G472SBIOMARTBreast Cancer21930507, 21930502
ENSP00000347683R397HBIOMARTPancreatic Cancer21930507, 21930502

Differential expressed protein
PKHA4_HUMAN is not differential expressed protein.

Hyperphosphorylation site
PKHA4_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
AKT1_HUMANPKHA4_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
PKHA4_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005737cytoplasmIEAcellular_component
GO:00055451-phosphatidylinositol bindingNASmolecular_function
GO:0005543phospholipid bindingIEAmolecular_function
GO:0016020membraneIEAcellular_component
GO:0005515protein bindingIEAmolecular_function
GO:0008150biological_processNDbiological_process
GO:0005575cellular_componentNDcellular_component


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