| UniProt/SwissProt ID: | PIPNA_HUMAN |
| Description: | phosphatidylinositol transfer protein, alpha [Source:HGNC Symbol;Acc:9001] |
| Location: | chr17 p13.3 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| Y57 | GEKGQyTHKIY | phosphoELM | |
| T58 | EKGQYtHKIYH | IP_trans | PhosphoSitePlus |
| Y93 | WNAYPyCRTVI | IP_trans | PhosphoSitePlus |
| Y140 | HVEAVyIDIAD | IP_trans | PhosphoSitePlus |
| S165 | PAKFKsIKTGR | PKCa(PKC alpha | RegPhos |
| S165 | PAKFKsIKTGR | PKC_alpha | phosphoELM |
| S165 | PAKFKsIKTGR | IP_trans | PhosphoSitePlus |
| Y57 | GEKGQyTHKIY | IP_trans | PhosphoSitePlus |
| Dephosphorylation site |
| PIPNA_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000316809 | V136M | COSMIC | Ovarian Cancer | 21720365 | ENSP00000316809 | V136M | COSMIC | Ovarian Cancer | 21720365 |
| Differential expressed protein |
| Ensembl ID | Cancer name | Design | Sample | Change | Ratio | Pubmed |
|---|---|---|---|---|---|---|
| ENSP00000316809 | colorectal cancer | Normal vs. Cancer | tissue | Down | 0.74 | 19098285 | ENSP00000316809 | Uterine Cancer | Normal vs. Cancer | tissue | Up | 16051329 | ENSP00000316809 | Uterine Cancer | Normal vs. Cancer | tissue | Up | 19771267 |
| Hyperphosphorylation site |
| PIPNA_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| KPCA_HUMAN | PIPNA_HUMAN | kinase -> substrate | Robert H Newman (2013) |
| Function Annotation |
| KEGG Pathway |
| PIPNA_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0015914 | phospholipid transport | IEA | biological_process |
| GO:0008526 | phosphatidylinositol transporter activity | TAS | molecular_function |
| GO:0006810 | transport | IEA | biological_process |
| GO:0007601 | visual perception | TAS | biological_process |
| GO:0000062 | fatty-acyl-CoA binding | IEA | molecular_function |
| GO:0005543 | phospholipid binding | IEA | molecular_function |
| GO:0007411 | axon guidance | TAS | biological_process |
| GO:0035091 | phosphatidylinositol binding | IEA | molecular_function |
| GO:0008525 | phosphatidylcholine transporter activity | TAS | molecular_function |
| GO:0005622 | intracellular | IEA | cellular_component |
| GO:0006629 | lipid metabolic process | NAS | biological_process |
| GO:0005737 | cytoplasm | IEA | cellular_component |
| GO:0070540 | stearic acid binding | IEA | molecular_function |