Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:PINK1_HUMAN
Description:PTEN induced putative kinase 1 [Source:HGNC Symbol;Acc:14581]
Location:chr1 p36.12
Node attribute:kinase

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T257EYGAVtYRKSKPhosphoSitePlus
S402QLPFSsWYVDRPkinasePhosphoSitePlus
T313LGHGRtLFLVMPkinasePhosphoSitePlus
S228NISAGsSSEAIPhosphoSitePlus

Dephosphorylation site
PINK1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000364204P215LGreenman2007Central Nervous System Neoplasms16618716, 17344846, 18428421
ENSP00000364204P215LGreenman2007, HPINeoplasms by Histologic Type16618716, 17344846, 18428421
ENSP00000364204V482MTCGAOvarian Cancer21720365, 18772890

Differential expressed protein
PINK1_HUMAN is not differential expressed protein.

Hyperphosphorylation site
PINK1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
PINK1_HUMANKKCC1_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
PINK1_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005741mitochondrial outer membraneIEAcellular_component
GO:0006950response to stressIDAbiological_process
GO:0097237cellular response to toxinIEAbiological_process
GO:0006468protein phosphorylationIDAbiological_process
GO:0016301kinase activityIEAmolecular_function
GO:0005829cytosolIDAcellular_component
GO:0005515protein bindingIPImolecular_function
GO:0018105peptidyl-serine phosphorylationIDAbiological_process
GO:0043254regulation of protein complex assemblyIDAbiological_process
GO:0005524ATP bindingIDAmolecular_function
GO:0031625ubiquitin protein ligase bindingIPImolecular_function
GO:0031396regulation of protein ubiquitinationIDAbiological_process
GO:0033605positive regulation of catecholamine secretionIEAbiological_process
GO:0007243intracellular protein kinase cascadeIDAbiological_process
GO:0016301kinase activityIDAmolecular_function
GO:0005739mitochondrionIDAcellular_component
GO:0000287magnesium ion bindingIDAmolecular_function
GO:0004713protein tyrosine kinase activityIEAmolecular_function
GO:0004672protein kinase activityIEAmolecular_function
GO:0016021integral to membraneIEAcellular_component
GO:0043123positive regulation of I-kappaB kinase/NF-kappaB cIDAbiological_process
GO:0055131C3HC4-type RING finger domain bindingIPImolecular_function
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0090200positive regulation of release of cytochrome c froIMPbiological_process
GO:0043524negative regulation of neuron apoptotic processIEAbiological_process
GO:0010857calcium-dependent protein kinase activityIDAmolecular_function
GO:0033603positive regulation of dopamine secretionIEAbiological_process
GO:0006468protein phosphorylationIEAbiological_process
GO:0000422mitochondrion degradationIMPbiological_process
GO:0043523regulation of neuron apoptotic processIEAbiological_process
GO:0005739mitochondrionIEAcellular_component
GO:0004674protein serine/threonine kinase activityIDAmolecular_function
GO:0032226positive regulation of synaptic transmission, dopaIEAbiological_process
GO:0008219cell deathIEAbiological_process


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