| UniProt/SwissProt ID: | PIN4_HUMAN |
| Description: | protein (peptidylprolyl cis/trans isomerase) NIMA-interacting, 4 (parvulin) [Source:HGNC Symbol;Acc:8992] |
| Location: | chrX q13.1 |
| Node attribute: | substrate |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| Y122 | KTKFGyHIIMV | Rotamase_3 | PhosphoSitePlus |
| S44 | KGGAAsGSDSA | CSNK2A2 | HPRD |
| S19 | KGGAAsGSDSA | CK2_group | phosphoELM; RegPhos |
| S19 | KGGAAsGSDSA | PhosphoSitePlus | |
| S19 | KGGAAsGSDSA | CK2a2 | RegPhos |
| S44 | KGGAAsGSDSA | CSNK2A1 | HPRD |
| S19 | KGGAAsGSDSA | CK2a1-rs | RegPhos |
| S19 | KGGAAsGSDSA | CK2a1 | RegPhos |
| Y147 | KTKFGyHIIMV | HPRD | |
| Dephosphorylation site |
| PIN4_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000362773 | *157S | COSMIC | Melanoma | 9354451 |
| Differential expressed protein |
| PIN4_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| PIN4_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| CSK22_HUMAN | PIN4_HUMAN | kinase -> substrate | HPRD |
| CSK21_HUMAN | PIN4_HUMAN | kinase -> substrate | HPRD |
| Function Annotation |
| KEGG Pathway |
| PIN4_HUMAN is not in KEGG pathway. |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0005819 | spindle | IEA | cellular_component |
| GO:0005730 | nucleolus | IEA | cellular_component |
| GO:0005759 | mitochondrial matrix | IEA | cellular_component |
| GO:0003677 | DNA binding | IEA | molecular_function |
| GO:0005634 | nucleus | IDA | cellular_component |
| GO:0016853 | isomerase activity | IEA | molecular_function |
| GO:0005737 | cytoplasm | IDA | cellular_component |
| GO:0006457 | protein folding | IEA | biological_process |
| GO:0003681 | bent DNA binding | IDA | molecular_function |
| GO:0006364 | rRNA processing | IMP | biological_process |
| GO:0030684 | preribosome | IDA | cellular_component |
| GO:0003755 | peptidyl-prolyl cis-trans isomerase activity | IEA | molecular_function |
| GO:0003690 | double-stranded DNA binding | IDA | molecular_function |