Phosphorylation

Protein information

UniProt/SwissProt ID:	PI2R_HUMAN
Description:	prostaglandin I2 (prostacyclin) receptor (IP) [Source:HGNC Symbol;Acc:9602]
Location:	chr19 q13.32
Node attribute:	substrate; PPI(target)

Position	PhosphoPeptide	Catalytic kinase	Source
S328	LSQLAsGRRDP	PRKCA	HPRD
S328	LSQLAsGRRDP	PKCa	RegPhos
S328	LSQLAsGRRDP	PKCa(PKC alpha	RegPhos
S328	LSQLAsGRRDP	PKC_alpha	phosphoELM
S328	LSQLAsGRRDP		PhosphoSitePlus

PI2R_HUMAN do not have dephosphorylation site.

Ensembl ID	Variation	Source	Cancer name	Pubmed
ENSP00000291294	P339S	COSMIC	Skin Cancer	21984974

PI2R_HUMAN is not differential expressed protein.

PI2R_HUMAN do not have hyperphosphorylation site.

Source	Target	Relationship	Resource
KPCA_HUMAN	PI2R_HUMAN	kinase -> substrate	HPRD; Robert H Newman (2013)
GLHA_HUMAN	PI2R_HUMAN	other	KEGG

KEGG Pathway

KEGG ID	Pathway
hsa04270	Vascular smooth muscle contraction
hsa04080	Neuroactive ligand-receptor interaction

Gene Ontology

GO ID	GO_Term	Evidence	Ontology
GO:0048662	negative regulation of smooth muscle cell prolifer	IEA	biological_process
GO:0007189	adenylate cyclase-activating G-protein coupled rec	IEA	biological_process
GO:0007189	adenylate cyclase-activating G-protein coupled rec	IMP	biological_process
GO:0007267	cell-cell signaling	TAS	biological_process
GO:0016021	integral to membrane	IEA	cellular_component
GO:0005886	plasma membrane	IDA	cellular_component
GO:0043950	positive regulation of cAMP-mediated signaling	IMP	biological_process
GO:0007186	G-protein coupled receptor signaling pathway	IEA	biological_process
GO:0030819	positive regulation of cAMP biosynthetic process	IEA	biological_process
GO:0005085	guanyl-nucleotide exchange factor activity	TAS	molecular_function
GO:0005829	cytosol	IDA	cellular_component
GO:0007187	G-protein coupled receptor signaling pathway, coup	TAS	biological_process
GO:0005887	integral to plasma membrane	TAS	cellular_component
GO:0030819	positive regulation of cAMP biosynthetic process	IMP	biological_process
GO:0010642	negative regulation of platelet-derived growth fac	IEA	biological_process
GO:0043950	positive regulation of cAMP-mediated signaling	IEA	biological_process
GO:0032496	response to lipopolysaccharide	IEA	biological_process
GO:0007596	blood coagulation	TAS	biological_process
GO:0004930	G-protein coupled receptor activity	IEA	molecular_function
GO:0048662	negative regulation of smooth muscle cell prolifer	IDA	biological_process
GO:0010642	negative regulation of platelet-derived growth fac	ISS	biological_process

Human Phosphorylation Mediated
Signaling Transduction Network