Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:PI2R_HUMAN
Description:prostaglandin I2 (prostacyclin) receptor (IP) [Source:HGNC Symbol;Acc:9602]
Location:chr19 q13.32
Node attribute:substrate; PPI(target)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S328LSQLAsGRRDPPRKCAHPRD
S328LSQLAsGRRDPPKCaRegPhos
S328LSQLAsGRRDPPKCa(PKC alphaRegPhos
S328LSQLAsGRRDPPKC_alphaphosphoELM
S328LSQLAsGRRDPPhosphoSitePlus

Dephosphorylation site
PI2R_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000291294P339SCOSMICSkin Cancer21984974

Differential expressed protein
PI2R_HUMAN is not differential expressed protein.

Hyperphosphorylation site
PI2R_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
KPCA_HUMANPI2R_HUMANkinase -> substrateHPRD; Robert H Newman (2013)
GLHA_HUMANPI2R_HUMANotherKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04270Vascular smooth muscle contraction
hsa04080Neuroactive ligand-receptor interaction

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0048662negative regulation of smooth muscle cell proliferIEAbiological_process
GO:0007189adenylate cyclase-activating G-protein coupled recIEAbiological_process
GO:0007189adenylate cyclase-activating G-protein coupled recIMPbiological_process
GO:0007267cell-cell signalingTASbiological_process
GO:0016021integral to membraneIEAcellular_component
GO:0005886plasma membraneIDAcellular_component
GO:0043950positive regulation of cAMP-mediated signalingIMPbiological_process
GO:0007186G-protein coupled receptor signaling pathwayIEAbiological_process
GO:0030819positive regulation of cAMP biosynthetic processIEAbiological_process
GO:0005085guanyl-nucleotide exchange factor activityTASmolecular_function
GO:0005829cytosolIDAcellular_component
GO:0007187G-protein coupled receptor signaling pathway, coupTASbiological_process
GO:0005887integral to plasma membraneTAScellular_component
GO:0030819positive regulation of cAMP biosynthetic processIMPbiological_process
GO:0010642negative regulation of platelet-derived growth facIEAbiological_process
GO:0043950positive regulation of cAMP-mediated signalingIEAbiological_process
GO:0032496response to lipopolysaccharideIEAbiological_process
GO:0007596blood coagulationTASbiological_process
GO:0004930G-protein coupled receptor activityIEAmolecular_function
GO:0048662negative regulation of smooth muscle cell proliferIDAbiological_process
GO:0010642negative regulation of platelet-derived growth facISSbiological_process


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