Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:PHX2B_HUMAN
Description:paired-like homeobox 2b [Source:HGNC Symbol;Acc:9143]
Location:chr4 p13
Node attribute:TF

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T87PYKLFtDHGGLPhosphoSitePlus
S171AAKNGsSGKKSPhosphoSitePlus
Y78HQSSPyAAVPYPhosphoSitePlus
S172AKNGSsGKKSDPhosphoSitePlus
S176SSGKKsDSSRDPhosphoSitePlus

Dephosphorylation site
PHX2B_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000226382R100LOMIMNeoplasms by Histologic Type15024693
ENSP00000226382F146CDing2008, BIOMARTLung Cancer18948947, 21930507, 21930502
ENSP00000226382G197DOMIMNeoplasms by Histologic Type16691592
ENSP00000226382R141GOMIMNeoplasms by Histologic Type15024693 9516825 12438263

Differential expressed protein
PHX2B_HUMAN is not differential expressed protein.

Hyperphosphorylation site
PHX2B_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
PHX2B_HUMANPHX2A_HUMANTF -> target geneTRANSFAC

Function Annotation
KEGG Pathway
PHX2B_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0048839inner ear developmentIEAbiological_process
GO:0048486parasympathetic nervous system developmentISSbiological_process
GO:0071542dopaminergic neuron differentiationISSbiological_process
GO:0006355regulation of transcription, DNA-dependentIEAbiological_process
GO:0000978RNA polymerase II core promoter proximal region seIDAmolecular_function
GO:0000977RNA polymerase II regulatory region sequence-speciIDAmolecular_function
GO:0048839inner ear developmentISSbiological_process
GO:0045665negative regulation of neuron differentiationIEAbiological_process
GO:0060541respiratory system developmentISSbiological_process
GO:0061452retrotrapezoid nucleus neuron differentiationIEAbiological_process
GO:0045666positive regulation of neuron differentiationIEAbiological_process
GO:0071773cellular response to BMP stimulusISSbiological_process
GO:1901166neural crest cell migration involved in autonomic IEAbiological_process
GO:0060541respiratory system developmentIEAbiological_process
GO:0048485sympathetic nervous system developmentIEAbiological_process
GO:0021934hindbrain tangential cell migrationIEAbiological_process
GO:0071773cellular response to BMP stimulusIEAbiological_process
GO:0048894efferent axon development in a lateral line nerveIEAbiological_process
GO:0045944positive regulation of transcription from RNA polyIEAbiological_process
GO:0030182neuron differentiationIEAbiological_process
GO:0045944positive regulation of transcription from RNA polyIDAbiological_process
GO:0021723medullary reticular formation developmentISSbiological_process
GO:1901166neural crest cell migration involved in autonomic ISSbiological_process
GO:0048894efferent axon development in a lateral line nerveISSbiological_process
GO:0061452retrotrapezoid nucleus neuron differentiationISSbiological_process
GO:0003677DNA bindingIEAmolecular_function
GO:0003360brainstem developmentIEPbiological_process
GO:0008285negative regulation of cell proliferationIEAbiological_process
GO:0048485sympathetic nervous system developmentISSbiological_process
GO:0048468cell developmentIEAbiological_process
GO:0001764neuron migrationISSbiological_process
GO:0048484enteric nervous system developmentIEPbiological_process
GO:0010001glial cell differentiationIEAbiological_process
GO:0048483autonomic nervous system developmentIMPbiological_process
GO:0005634nucleusIEAcellular_component
GO:0043565sequence-specific DNA bindingIEAmolecular_function
GO:0003357noradrenergic neuron differentiationISSbiological_process
GO:0021934hindbrain tangential cell migrationISSbiological_process
GO:0000790nuclear chromatinIDAcellular_component
GO:0006351transcription, DNA-dependentIEAbiological_process
GO:0071542dopaminergic neuron differentiationIEAbiological_process
GO:0002087regulation of respiratory gaseous exchange by neurIEAbiological_process
GO:0048486parasympathetic nervous system developmentIEAbiological_process
GO:0021723medullary reticular formation developmentIEAbiological_process
GO:0002087regulation of respiratory gaseous exchange by neurISSbiological_process
GO:0003700sequence-specific DNA binding transcription factorIEAmolecular_function
GO:0021533cell differentiation in hindbrainIEAbiological_process
GO:0010001glial cell differentiationISSbiological_process
GO:0048484enteric nervous system developmentIEAbiological_process
GO:0021533cell differentiation in hindbrainISSbiological_process
GO:0001764neuron migrationIEAbiological_process
GO:0003357noradrenergic neuron differentiationIEAbiological_process