Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:PGFRA_HUMAN
Description:platelet-derived growth factor receptor, alpha polypeptide [Source:HGNC Symbol;Acc:8803]
Location:chr4 q12
Node attribute:substrate; kinase; receptor; PPI(target)

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
Y962QYKKSyEKIHLPhosphoSitePlus
Y1018SADSGyIIPLPPhosphoSitePlus; phosphoELM
S566VIESIsPDGHEPhosphoSitePlus
S760SDIQRsLYDRPPkinase_TyrPhosphoSitePlus
Y754KEVSKySDIQRPDGFR_alphaphosphoELM
Y720ESTRSyVILSFPkinase_TyrPhosphoSitePlus
Y988DSDNAyIGVTYPDGFRaRegPhos
Y988DSDNAyIGVTYPDGFRAHPRD
Y1018SADSGyIIPLPPDGFR_alphaphosphoELM
Y993YIGVTyKNEEDPhosphoSitePlus; HPRD; RegPhos
Y731ENNGDyMDMKQHPRD; phosphoELM; RegPhos
Y1018SADSGyIIPLPPDGFRaRegPhos
Y944KRPSFyHLSEIPkinase_TyrPhosphoSitePlus
Y572PDGHEyIYVDPPhosphoSitePlus; phosphoELM; RegPhos
Y754KEVSKySDIQRPkinase_TyrPhosphoSitePlus
Y762IQRSLyDRPASPDGFRaRegPhos
Y762IQRSLyDRPASPDGFRAHPRD
S767YDRPAsYKKKSHPRD; phosphoELM; RegPhos
S847DIMHDsNYVSKPkinase_TyrPhosphoSitePlus
Y849MHDSNyVSKGSHPRD; phosphoELM
Y988DSDNAyIGVTYPhosphoSitePlus
S1081IGIDSsDLVEDPhosphoSitePlus
S1048QTSEEsAIETGPhosphoSitePlus
Y742ADTTQyVPMLEHPRD; phosphoELM; RegPhos; SysPTM
S752ERKEVsKYSDIPkinase_TyrPhosphoSitePlus
T739MKQADtTQYVPPkinase_TyrPhosphoSitePlus
Y582PMQLPyDSRWEPhosphoSitePlus
Y613VEGTAyGLSRSPkinase_TyrPhosphoSitePlus
Y720ESTRSyVILSFHPRD; phosphoELM; RegPhos
S767YDRPAsYKKKSPkinase_TyrPhosphoSitePlus
Y958LLPGQyKKSYEPhosphoSitePlus
Y768DRPASyKKKSMHPRD; phosphoELM; RegPhos
Y1018SADSGyIIPLPPDGFRAHPRD
S584QLPYDsRWEFPPhosphoSitePlus
S1042RNRHSsQTSEEPhosphoSitePlus
S1080DIGIDsSDLVEPhosphoSitePlus
Y762IQRSLyDRPASphosphoELM
Y926ATSEVyEIMVKPkinase_TyrPhosphoSitePlus
S1087DLVEDsFL___PhosphoSitePlus
S755EVSKYsDIQRSPkinase_TyrPhosphoSitePlus
Y768DRPASyKKKSMPkinase_TyrPhosphoSitePlus
S1041KRNRHsSQTSEPhosphoSitePlus
Y574GHEYIyVDPMQPhosphoSitePlus; phosphoELM; RegPhos
S1016RLSADsGYIIPPhosphoSitePlus
Y731ENNGDyMDMKQPkinase_TyrPhosphoSitePlus
Y762IQRSLyDRPASPkinase_TyrPhosphoSitePlus
Y849MHDSNyVSKGSPkinase_TyrPhosphoSitePlus
Y762IQRSLyDRPASPDGFR_alphaphosphoELM
Y742ADTTQyVPMLEPkinase_TyrPhosphoSitePlus; SysPTM
Y849MHDSNyVSKGSautocatalysis RegPhos
S851DSNYVsKGSTFHPRD
T740KQADTtQYVPMPkinase_TyrPhosphoSitePlus
Y988DSDNAyIGVTYPDGFR_alphaphosphoELM
Y754KEVSKySDIQRPDGFRAHPRD
Y754KEVSKySDIQRPDGFRaRegPhos

Dephosphorylation site
PGFRA_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000257290D1071NGreenman2007, HPILung Cancer16140923, 17344846, 18428421
ENSP00000257290A210VDing2008, BIOMARTLung Cancer18948947, 21930507, 21930502
ENSP00000257290D480EDing2008Lung Cancer18948947
ENSP00000257290C235YTCGANeoplasms by Histologic Type21720365, 18772890
ENSP00000257290W549*Ding2008, BIOMARTLung Cancer18948947, 21930507, 21930502
ENSP00000257290D842VOMIMGastric Cancer12522257
ENSP00000257290W349CTCGANeoplasms by Histologic Type21720365, 18772890
ENSP00000257290V193IDing2008, BIOMARTLung Cancer18948947, 21930507, 21930502
ENSP00000425648F178SBIOMARTBreast Cancer21930507, 21930502
ENSP00000257290Y555COMIMGastric Cancer17087943 3152526 3152525
ENSP00000257290F178SBIOMARTBreast Cancer21930507, 21930502
ENSP00000257290Y59NTCGAOvarian Cancer21720365, 18772890
ENSP00000257290Y849CHPIGastric Cancer15928335
ENSP00000257290L580MDing2008, BIOMARTLung Cancer18948947, 21930507, 21930502
ENSP00000257290I1050TBIOMARTNeoplasms by Histologic Type21930507, 21930502
ENSP00000257290V561DOMIMGastric Cancer12522257 17566086
ENSP00000257290G829RGreenman2007, HPINeoplasms by Histologic Type16618716, 17344846, 18428421
ENSP00000257290C23WBIOMARTBreast Cancer21930507, 21930502
ENSP00000257290D480EBIOMARTLung Cancer21930507, 21930502
ENSP00000257290D846YOMIMGastric Cancer14699510
ENSP00000257290V561DOMIMNeoplasms by Histologic Type12522257 17566086
ENSP00000257290V536ETCGANeoplasms by Histologic Type21720365, 18772890
ENSP00000257290G829RGreenman2007Central Nervous System Neoplasms16618716, 17344846, 18428421
ENSP00000257290V499MBIOMARTBreast Cancer21930507, 21930502
ENSP00000257290M133KDing2008, BIOMARTLung Cancer18948947, 21930507, 21930502
ENSP00000425648C23WBIOMARTBreast Cancer21930507, 21930502
ENSP00000257290Q431RTCGAOvarian Cancer21720365, 18772890
ENSP00000257290E996KGreenman2007Skin Cancer17344846, 18428421
ENSP00000257290E338QDing2008, BIOMARTLung Cancer18948947, 21930507, 21930502

Differential expressed protein
PGFRA_HUMAN is not differential expressed protein.

Hyperphosphorylation site
SiteMotifPeptideCancer namePubmedSource
Y762Pkinase_TyrSDIQRSLyDRPASYKcholangiocellular carcinoma21253578PhosphoSitePlus

Direct Interaction Pair
SourceTargetRelationshipResource
PDGFA_HUMANPGFRA_HUMANligand -> receptorHPMR
PDGFC_HUMANPGFRA_HUMANligand -> receptorHPMR
PDGFB_HUMANPGFRA_HUMANligand -> receptorHPMR
PGFRA_HUMANPGFRA_HUMANkinase -> substrateHPRD
ZAGL2_HUMANPGFRA_HUMANkinase -> substrateRegPhos
PDGFB_HUMANPGFRA_HUMANotherKEGG
PDGFC_HUMANPGFRA_HUMANotherKEGG
PDGFA_HUMANPGFRA_HUMANotherKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa05214Glioma
hsa04810Regulation of actin cytoskeleton
hsa05215Prostate cancer
hsa05166HTLV-I infection
hsa04144Endocytosis
hsa05218Melanoma
hsa04540Gap junction
hsa04060Cytokine-cytokine receptor interaction
hsa04510Focal adhesion
hsa04010MAPK signaling pathway
hsa04020Calcium signaling pathway
hsa05200Pathways in cancer

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0006468protein phosphorylationIEAbiological_process
GO:0005886plasma membraneTAScellular_component
GO:0043552positive regulation of phosphatidylinositol 3-kinaIMPbiological_process
GO:0070527platelet aggregationIMPbiological_process
GO:0010544negative regulation of platelet activationIDAbiological_process
GO:0005887integral to plasma membraneIDAcellular_component
GO:0042803protein homodimerization activityIDAmolecular_function
GO:0009897external side of plasma membraneIEAcellular_component
GO:0005524ATP bindingIEAmolecular_function
GO:0071230cellular response to amino acid stimulusIEAbiological_process
GO:0048407platelet-derived growth factor bindingIEAmolecular_function
GO:0048557embryonic digestive tract morphogenesisIEAbiological_process
GO:0060325face morphogenesisIEAbiological_process
GO:0038085vascular endothelial growth factor bindingIPImolecular_function
GO:0048701embryonic cranial skeleton morphogenesisIEAbiological_process
GO:0030539male genitalia developmentIEAbiological_process
GO:0014068positive regulation of phosphatidylinositol 3-kinaTASbiological_process
GO:0060326cell chemotaxisIEAbiological_process
GO:0048008platelet-derived growth factor receptor signaling IDAbiological_process
GO:0033327Leydig cell differentiationIEAbiological_process
GO:0004672protein kinase activityIEAmolecular_function
GO:0055003cardiac myofibril assemblyIEAbiological_process
GO:0016021integral to membraneIEAcellular_component
GO:0016477cell migrationIEAbiological_process
GO:0061298retina vasculature development in camera-type eyeIEAbiological_process
GO:0048010vascular endothelial growth factor receptor signalIEAbiological_process
GO:0008585female gonad developmentIEAbiological_process
GO:0010863positive regulation of phospholipase C activityIMPbiological_process
GO:2000249regulation of actin cytoskeleton reorganizationTASbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0008210estrogen metabolic processIEAbiological_process
GO:0048705skeletal system morphogenesisIEAbiological_process
GO:0072277metanephric glomerular capillary formationIEAbiological_process
GO:0023019signal transduction involved in regulation of geneIEAbiological_process
GO:0001553luteinizationIEAbiological_process
GO:0048146positive regulation of fibroblast proliferationIDAbiological_process
GO:0030325adrenal gland developmentIEAbiological_process
GO:0018108peptidyl-tyrosine phosphorylationIDAbiological_process
GO:0005021vascular endothelial growth factor-activated recepIDAmolecular_function
GO:0060021palate developmentIEAbiological_process
GO:0005737cytoplasmISScellular_component
GO:0004714transmembrane receptor protein tyrosine kinase actIDAmolecular_function
GO:0048008platelet-derived growth factor receptor signaling IEAbiological_process
GO:0038091positive regulation of cell proliferation by VEGF-IDAbiological_process
GO:0046777protein autophosphorylationIDAbiological_process
GO:0035790platelet-derived growth factor receptor-alpha signIEAbiological_process
GO:2000739regulation of mesenchymal stem cell differentiatioIMPbiological_process
GO:0031226intrinsic to plasma membraneIDAcellular_component
GO:0008284positive regulation of cell proliferationIMPbiological_process
GO:0005161platelet-derived growth factor receptor bindingIPImolecular_function
GO:0050920regulation of chemotaxisIMPbiological_process
GO:0004713protein tyrosine kinase activityIEAmolecular_function
GO:0019048virus-host interactionIEAbiological_process
GO:0048704embryonic skeletal system morphogenesisISSbiological_process
GO:0042475odontogenesis of dentin-containing toothIEAbiological_process
GO:0030324lung developmentIEAbiological_process
GO:0001775cell activationTASbiological_process
GO:0007169transmembrane receptor protein tyrosine kinase sigIEAbiological_process
GO:0007204elevation of cytosolic calcium ion concentrationIMPbiological_process
GO:0045740positive regulation of DNA replicationIDAbiological_process
GO:0016772transferase activity, transferring phosphorus-contIEAmolecular_function
GO:0070374positive regulation of ERK1 and ERK2 cascadeIMPbiological_process
GO:0005634nucleusISScellular_component
GO:0030335positive regulation of cell migrationIMPbiological_process
GO:0042060wound healingIEAbiological_process
GO:0048015phosphatidylinositol-mediated signalingIMPbiological_process
GO:0009887organ morphogenesisIEAbiological_process
GO:0001701in utero embryonic developmentIEAbiological_process
GO:0030198extracellular matrix organizationIEAbiological_process
GO:0009653anatomical structure morphogenesisIEAbiological_process
GO:0005018platelet-derived growth factor alpha-receptor actiIDAmolecular_function