Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:PE2R4_HUMAN
Description:prostaglandin E receptor 4 (subtype EP4) [Source:HGNC Symbol;Acc:9596]
Location:chr5 p13.1
Node attribute:GPCR

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
T394SSTSQtLLPDLPhosphoSitePlus
T433TTSLRtLRISEPKC_groupphosphoELM
S377AMSGHsRSFISPhosphoSitePlus; phosphoELM
S379SGHSRsFISREPhosphoSitePlus; phosphoELM
S430QEDTTsLRTLRPKC_groupphosphoELM
S382SRSFIsRELKEPhosphoSitePlus; phosphoELM
S484ETLNLsEKPKC_groupphosphoELM
S389ELKEIsSTSQTPhosphoSitePlus
S400LLPDLsLPDLSPhosphoSitePlus
S222FMRRTsLGTEQPKA_groupphosphoELM
S374TSSAMsGHSRSPhosphoSitePlus; phosphoELM
S252ALPRLsDFRRR7tm_1PhosphoSitePlus
S354CRIGGsRRERSPKC_groupphosphoELM
S259FRRRRsFRRIAPKA_groupphosphoELM
S460DEAGGsGRAGPPKC_groupphosphoELM
S259FRRRRsFRRIAPKC_groupphosphoELM

Dephosphorylation site
PE2R4_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000302846S400LCOSMICLung Cancer20668451
ENSP00000302846S460RCOSMICHead and Neck Cancer21798893

Differential expressed protein
PE2R4_HUMAN is not differential expressed protein.

Hyperphosphorylation site
PE2R4_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
PE2R4_HUMANGNAS1_HUMANGPCR -> GproteingpDB
PE2R4_HUMANGNAS2_HUMANGPCR -> GproteingpDB

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04080Neuroactive ligand-receptor interaction

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0004930G-protein coupled receptor activityIEAmolecular_function
GO:0051492regulation of stress fiber assemblyISSbiological_process
GO:0004957prostaglandin E receptor activityIDAmolecular_function
GO:0050710negative regulation of cytokine secretionIEAbiological_process
GO:0005886plasma membraneTAScellular_component
GO:0070371ERK1 and ERK2 cascadeISSbiological_process
GO:0051492regulation of stress fiber assemblyIEAbiological_process
GO:0033624negative regulation of integrin activationIDAbiological_process
GO:0050710negative regulation of cytokine secretionISSbiological_process
GO:0071260cellular response to mechanical stimulusIEAbiological_process
GO:0007188adenylate cyclase-modulating G-protein coupled recIDAbiological_process
GO:0050728negative regulation of inflammatory responseIDAbiological_process
GO:0060348bone developmentISSbiological_process
GO:0007254JNK cascadeISSbiological_process
GO:0006955immune responseIEPbiological_process
GO:0005515protein bindingIPImolecular_function
GO:0007254JNK cascadeIEAbiological_process
GO:0016021integral to membraneNAScellular_component
GO:0071260cellular response to mechanical stimulusISSbiological_process
GO:0042093T-helper cell differentiationISSbiological_process
GO:0070371ERK1 and ERK2 cascadeIEAbiological_process
GO:0050729positive regulation of inflammatory responseIEAbiological_process
GO:0060348bone developmentIEAbiological_process
GO:0032496response to lipopolysaccharideIEAbiological_process
GO:2000420negative regulation of eosinophil extravasationIDAbiological_process
GO:0007186G-protein coupled receptor signaling pathwayIEAbiological_process
GO:0050715positive regulation of cytokine secretionISSbiological_process
GO:0009612response to mechanical stimulusIEPbiological_process
GO:0030278regulation of ossificationIEAbiological_process
GO:0042093T-helper cell differentiationIEAbiological_process
GO:0050715positive regulation of cytokine secretionIEAbiological_process
GO:0050729positive regulation of inflammatory responseISSbiological_process


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