Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:PDLI5_HUMAN
Description:PDZ and LIM domain 5 [Source:HGNC Symbol;Acc:17468]
Location:chr4 q22.3
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S134PRPFGsVSSPKPhosphoSitePlus; HPRD; phosphoELM; SysPTM
S200KKANNsQEPSPHPRD
Y250ERYTEfYHVPTHPRD
S319PQLASsVASTRHPRD; phosphoELM
T248IVERYtEFYHVPhosphoSitePlus
T381ISNSAtYSGSVPhosphoSitePlus; HPRD
S362VIKSPsWQRPNPhosphoSitePlus; HPRD
S251TGVIKsPSWQRHPRD
Y251RYTEFyHVPTHPhosphoSitePlus; HPRD; phosphoELM
S313NSQEPsPQLASPhosphoSitePlus; HPRD; phosphoELM
T208VPRQPtVTSVCPhosphoSitePlus
S318SPQLAsSVASTHPRD
S111PVPITsPAVSKPhosphoSitePlus; HPRD; phosphoELM; SysPTM
S253VIKSPsWQRPNHPRD
Y147ERYTEfYHVPTHPRD
T373QGVPStGRISNHPRD
S204NSQEPsPQLASHPRD
Y127ERYTEfYHVPTHPRD
Y455KNTMAyIGFVELIMPhosphoSitePlus
T452AHCKNtMAYIGLIMPhosphoSitePlus
S309KKANNsQEPSPPhosphoSitePlus; HPRD; phosphoELM
Y125TNNMAyNKAPRPhosphoSitePlus
S137FGSVSsPKVTSPhosphoSitePlus; HPRD; phosphoELM; SysPTM
Y144HIVERyTEFYHHPRD
S268STGRIsNSATYHPRD
Y466EKGALyCELCYLIMPhosphoSitePlus
S119GQRRGsQGDSKHPRD
Y128RYTEFyHVPTHHPRD
Y148RYTEFyHVPTHHPRD
S257HVPTHsDASKKPhosphoSitePlus
T110KPVPItSPAVSPhosphoSitePlus; HPRD; SysPTM
T272ISNSAtYSGSVHPRD
S228GQRRGsQGDSKPhosphoSitePlus; HPRD
Y138HIVERyTEFYHHPRD
T216SVCSEtSQELAPhosphoSitePlus
S377STGRIsNSATYHPRD
Y124HIVERyTEFYHHPRD
S360TGVIKsPSWQRPhosphoSitePlus; HPRD; SysPTM
T264QGVPStGRISNHPRD
S232GSQGDsKQQNGPhosphoSitePlus
S115TSPAVsKVTSTHPRD
S136PFGSVsSPKVTPhosphoSitePlus; HPRD; phosphoELM
S263NQGVPsTGRISHPRD
T255FYHVPtHSDASPhosphoSitePlus
S282TTQSRsFRILAPhosphoSitePlus
Y142RYTEFyHVPTHHPRD
S372NQGVPsTGRISHPRD
S210PQLASsVASTRHPRD
Y141ERYTEfYHVPTHPRD
S209SPQLAsSVASTHPRD
Y247HIVERyTEFYHPhosphoSitePlus; HPRD

Dephosphorylation site
PDLI5_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000398469P402HTCGAOvarian Cancer21720365, 18772890
ENSP00000321746R513WCOSMICMelanoma21499247
ENSP00000321746C213SCOSMICHead and Neck Cancer21798893
ENSP00000321746E443KCOSMICSkin Cancer21984974
ENSP00000321746P524HCOSMICOvarian Cancer21720365
ENSP00000398469P415HTCGAOvarian Cancer21720365, 18772890

Differential expressed protein
PDLI5_HUMAN is not differential expressed protein.

Hyperphosphorylation site
PDLI5_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
PDPK1_HUMANPDLI5_HUMANkinase -> substrateRobert H Newman (2013)
MK06_HUMANPDLI5_HUMANkinase -> substrateRobert H Newman (2013)

Function Annotation
KEGG Pathway
PDLI5_HUMAN is not in KEGG pathway.

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0008270zinc ion bindingIEAmolecular_function
GO:0014069postsynaptic densityISScellular_component
GO:0005515protein bindingIEAmolecular_function
GO:0047485protein N-terminus bindingIEAmolecular_function
GO:0061001regulation of dendritic spine morphogenesisISSbiological_process
GO:0051963regulation of synapse assemblyISSbiological_process
GO:0042805actinin bindingIEAmolecular_function
GO:0045211postsynaptic membraneIEAcellular_component
GO:0051963regulation of synapse assemblyIEAbiological_process
GO:0042805actinin bindingISSmolecular_function
GO:0005886plasma membraneIEAcellular_component
GO:0016020membraneIEAcellular_component
GO:0005829cytosolIEAcellular_component
GO:0014069postsynaptic densityIEAcellular_component
GO:0016020membraneISScellular_component
GO:0030018Z discIEAcellular_component
GO:0003779actin bindingIEAmolecular_function
GO:0005080protein kinase C bindingIEAmolecular_function
GO:0005829cytosolISScellular_component
GO:0015629actin cytoskeletonIDAcellular_component
GO:0003779actin bindingISSmolecular_function
GO:0061001regulation of dendritic spine morphogenesisIEAbiological_process
GO:0030054cell junctionIEAcellular_component
GO:0005080protein kinase C bindingISSmolecular_function


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