Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:PDK1_HUMAN
Description:pyruvate dehydrogenase kinase, isozyme 1 [Source:HGNC Symbol;Acc:8809]
Location:chr2 q31.1
Node attribute:kinase

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S393YIKALsTDSIEphosphoELM; RegPhos
T346RPRVEtSRAVPHATPase_cPhosphoSitePlus
S25RAAGFsRSFSSPDHK1RegPhos
Y243RLCDLyYINSPPhosphoSitePlus
S393YIKALsTDSIEPDK1HPRD
Y336LFNYMySTAPRHATPase_cPhosphoSitePlus
Y357LAGFGyGLPISHATPase_cPhosphoSitePlus
S347PRVETsRAVPLHATPase_cPhosphoSitePlus
S25RAAGFsRSFSSphosphoELM; RegPhos
S396ALSTDsIERLPphosphoELM; RegPhos
S396ALSTDsIERLPPDHK1RegPhos
Y136DAKAIyDFTDTBCDHK_Adom3PhosphoSitePlus
S67FLDFGsVNACEBCDHK_Adom3PhosphoSitePlus
S396ALSTDsIERLPPDK1HPRD
S393YIKALsTDSIEPDHK1RegPhos
Y403ERLPVyNKAAWPhosphoSitePlus
S25RAAGFsRSFSSPDK1HPRD
Y244LCDLYyINSPEPhosphoSitePlus

Dephosphorylation site
PDK1_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000282077C421YDing2008, BIOMARTLung Cancer18948947, 21930507, 21930502
ENSP00000386985C421YDing2008Lung Cancer18948947

Differential expressed protein
PDK1_HUMAN is not differential expressed protein.

Hyperphosphorylation site
PDK1_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
PDK1_HUMANAKT3_HUMANkinase -> substrateRegPhos
PDK1_HUMANITB3_HUMANkinase -> substrateRegPhos
PDK1_HUMANAKT1_HUMANkinase -> substrateRegPhos
PDK1_HUMANPKN2_HUMANkinase -> substrateRegPhos
PDK1_HUMANPDPK1_HUMANkinase -> substrateRegPhos
PDK1_HUMANODPA_HUMANkinase -> substrateRegPhos

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04664Fc epsilon RI signaling pathway
hsa05145Toxoplasmosis
hsa05160Hepatitis C
hsa04660T cell receptor signaling pathway
hsa04722Neurotrophin signaling pathway

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0005739mitochondrionIEAcellular_component
GO:0005524ATP bindingIEAmolecular_function
GO:0006006glucose metabolic processIEAbiological_process
GO:0004672protein kinase activityIDAmolecular_function
GO:0010510regulation of acetyl-CoA biosynthetic process fromTASbiological_process
GO:0006090pyruvate metabolic processTASbiological_process
GO:0004740pyruvate dehydrogenase (acetyl-transferring) kinasIMPmolecular_function
GO:0004674protein serine/threonine kinase activityIEAmolecular_function
GO:0010906regulation of glucose metabolic processIMPbiological_process
GO:0008631intrinsic apoptotic signaling pathway in response IMPbiological_process
GO:0005759mitochondrial matrixTAScellular_component
GO:0008283cell proliferationIMPbiological_process
GO:0097411hypoxia-inducible factor-1alpha signaling pathwayIMPbiological_process
GO:0044281small molecule metabolic processTASbiological_process
GO:0016301kinase activityIEAmolecular_function
GO:0006468protein phosphorylationIDAbiological_process


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