| UniProt/SwissProt ID: | PDK1_HUMAN |
| Description: | pyruvate dehydrogenase kinase, isozyme 1 [Source:HGNC Symbol;Acc:8809] |
| Location: | chr2 q31.1 |
| Node attribute: | kinase |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| S393 | YIKALsTDSIE | phosphoELM; RegPhos | |
| T346 | RPRVEtSRAVP | HATPase_c | PhosphoSitePlus |
| S25 | RAAGFsRSFSS | PDHK1 | RegPhos |
| Y243 | RLCDLyYINSP | PhosphoSitePlus | |
| S393 | YIKALsTDSIE | PDK1 | HPRD |
| Y336 | LFNYMySTAPR | HATPase_c | PhosphoSitePlus |
| Y357 | LAGFGyGLPIS | HATPase_c | PhosphoSitePlus |
| S347 | PRVETsRAVPL | HATPase_c | PhosphoSitePlus |
| S25 | RAAGFsRSFSS | phosphoELM; RegPhos | |
| S396 | ALSTDsIERLP | phosphoELM; RegPhos | |
| S396 | ALSTDsIERLP | PDHK1 | RegPhos |
| Y136 | DAKAIyDFTDT | BCDHK_Adom3 | PhosphoSitePlus |
| S67 | FLDFGsVNACE | BCDHK_Adom3 | PhosphoSitePlus |
| S396 | ALSTDsIERLP | PDK1 | HPRD |
| S393 | YIKALsTDSIE | PDHK1 | RegPhos |
| Y403 | ERLPVyNKAAW | PhosphoSitePlus | |
| S25 | RAAGFsRSFSS | PDK1 | HPRD |
| Y244 | LCDLYyINSPE | PhosphoSitePlus | |
| Dephosphorylation site |
| PDK1_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000282077 | C421Y | Ding2008, BIOMART | Lung Cancer | 18948947, 21930507, 21930502 | ENSP00000386985 | C421Y | Ding2008 | Lung Cancer | 18948947 |
| Differential expressed protein |
| PDK1_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| PDK1_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| PDK1_HUMAN | AKT3_HUMAN | kinase -> substrate | RegPhos |
| PDK1_HUMAN | ITB3_HUMAN | kinase -> substrate | RegPhos |
| PDK1_HUMAN | AKT1_HUMAN | kinase -> substrate | RegPhos |
| PDK1_HUMAN | PKN2_HUMAN | kinase -> substrate | RegPhos |
| PDK1_HUMAN | PDPK1_HUMAN | kinase -> substrate | RegPhos |
| PDK1_HUMAN | ODPA_HUMAN | kinase -> substrate | RegPhos |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04664 | Fc epsilon RI signaling pathway |
| hsa05145 | Toxoplasmosis |
| hsa05160 | Hepatitis C |
| hsa04660 | T cell receptor signaling pathway |
| hsa04722 | Neurotrophin signaling pathway |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0005739 | mitochondrion | IEA | cellular_component |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0006006 | glucose metabolic process | IEA | biological_process |
| GO:0004672 | protein kinase activity | IDA | molecular_function |
| GO:0010510 | regulation of acetyl-CoA biosynthetic process from | TAS | biological_process |
| GO:0006090 | pyruvate metabolic process | TAS | biological_process |
| GO:0004740 | pyruvate dehydrogenase (acetyl-transferring) kinas | IMP | molecular_function |
| GO:0004674 | protein serine/threonine kinase activity | IEA | molecular_function |
| GO:0010906 | regulation of glucose metabolic process | IMP | biological_process |
| GO:0008631 | intrinsic apoptotic signaling pathway in response | IMP | biological_process |
| GO:0005759 | mitochondrial matrix | TAS | cellular_component |
| GO:0008283 | cell proliferation | IMP | biological_process |
| GO:0097411 | hypoxia-inducible factor-1alpha signaling pathway | IMP | biological_process |
| GO:0044281 | small molecule metabolic process | TAS | biological_process |
| GO:0016301 | kinase activity | IEA | molecular_function |
| GO:0006468 | protein phosphorylation | IDA | biological_process |