| UniProt/SwissProt ID: | PDGFD_HUMAN |
| Description: | platelet derived growth factor D [Source:HGNC Symbol;Acc:30620] |
| Location: | chr11 q22.3 |
| Node attribute: | ligand |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| Y327 | KTVKKyHEVLQ | PDGF | PhosphoSitePlus |
| T273 | KRYSCtPRNYS | PDGF | PhosphoSitePlus |
| Dephosphorylation site |
| PDGFD_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000302193 | D196Y | Sjoblom2006 | Intestines Cancer | 16959974, 21930507, 21930502 | ENSP00000376865 | A267S | COSMIC | Head and Neck Cancer | 21798897 | ENSP00000376865 | D202Y | HPI | Colorectal Cancer | 16959974 | ENSP00000302193 | D196Y | BIOMART | Colorectal Cancer | 21930507, 21930502 | ENSP00000376865 | D202Y | COSMIC | Intestines Cancer | 16959974 |
| Differential expressed protein |
| PDGFD_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| PDGFD_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| PDGFD_HUMAN | PGFRB_HUMAN | ligand -> receptor | HPMR |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04540 | Gap junction |
| hsa04810 | Regulation of actin cytoskeleton |
| hsa04510 | Focal adhesion |
| hsa05215 | Prostate cancer |
| hsa05218 | Melanoma |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0005788 | endoplasmic reticulum lumen | TAS | cellular_component |
| GO:0005576 | extracellular region | TAS | cellular_component |
| GO:0000139 | Golgi membrane | TAS | cellular_component |
| GO:0071230 | cellular response to amino acid stimulus | IEA | biological_process |
| GO:0007275 | multicellular organismal development | IEA | biological_process |
| GO:0051781 | positive regulation of cell division | IEA | biological_process |
| GO:0008083 | growth factor activity | IEA | molecular_function |
| GO:0016020 | membrane | IEA | cellular_component |
| GO:0050730 | regulation of peptidyl-tyrosine phosphorylation | IEA | biological_process |