| UniProt/SwissProt ID: | PDE6A_HUMAN |
| Description: | phosphodiesterase 6A, cGMP-specific, rod, alpha [Source:HGNC Symbol;Acc:8785] |
| Location: | chr5 q32 |
| Node attribute: | effector |
| Phosphorylation site |
| Position | PhosphoPeptide | Catalytic kinase | Source |
|---|---|---|---|
| Y404 | GVATFyNRKDG | GAF | PhosphoSitePlus |
| T717 | MAMMMtACDLS | PDEase_I | PhosphoSitePlus |
| S180 | KNILAsPIMNG | GAF | PhosphoSitePlus |
| Y275 | LNCDRySVGLL | GAF | PhosphoSitePlus |
| Y264 | FHKALyTVRAF | GAF | PhosphoSitePlus |
| Dephosphorylation site |
| PDE6A_HUMAN do not have dephosphorylation site. |
| Mutation site |
| Ensembl ID | Variation | Source | Cancer name | Pubmed |
|---|---|---|---|---|
| ENSP00000255266 | D366E | COSMIC | Ovarian Cancer | 21720365 | ENSP00000255266 | E3* | COSMIC | Ovarian Cancer | 21720365 | ENSP00000255266 | E287K | COSMIC | Head and Neck Cancer | 21984974 | ENSP00000255266 | I449L | COSMIC | Head and Neck Cancer | 21798893 |
| Differential expressed protein |
| PDE6A_HUMAN is not differential expressed protein. |
| Hyperphosphorylation site |
| PDE6A_HUMAN do not have hyperphosphorylation site. |
| Direct Interaction Pair |
| Source | Target | Relationship | Resource |
|---|---|---|---|
| GNAT1_HUMAN | PDE6A_HUMAN | Gprotein -> effector | gpDB |
| Function Annotation |
| KEGG Pathway |
| KEGG ID | Pathway |
|---|---|
| hsa04744 | Phototransduction |
| hsa00230 | Purine metabolism |
| Gene Ontology |
| GO ID | GO_Term | Evidence | Ontology |
|---|---|---|---|
| GO:0047555 | 3',5'-cyclic-GMP phosphodiesterase activity | IMP | molecular_function |
| GO:0005886 | plasma membrane | IEA | cellular_component |
| GO:0005829 | cytosol | TAS | cellular_component |
| GO:0046037 | GMP metabolic process | IMP | biological_process |
| GO:0004114 | 3',5'-cyclic-nucleotide phosphodiesterase activity | IEA | molecular_function |
| GO:0007165 | signal transduction | IEA | biological_process |
| GO:0051480 | cytosolic calcium ion homeostasis | IMP | biological_process |
| GO:0005515 | protein binding | IEA | molecular_function |
| GO:0046872 | metal ion binding | IEA | molecular_function |
| GO:0060041 | retina development in camera-type eye | IEA | biological_process |
| GO:0003824 | catalytic activity | IEA | molecular_function |
| GO:0007596 | blood coagulation | TAS | biological_process |
| GO:0007601 | visual perception | IEA | biological_process |