Protein information
  Protein summary    Phosphorylation site    Dephosphorylation site    Mutation site
  Differential expressed protein    Hyperphosphorylation site    Direct interaction pair    Function Annotation

Protein Summary
UniProt/SwissProt ID:PDE3A_HUMAN
Description:phosphodiesterase 3A, cGMP-inhibited [Source:HGNC Symbol;Acc:8778]
Location:chr12 p12.2
Node attribute:substrate

Phosphorylation site
PositionPhosphoPeptideCatalytic kinaseSource
S463VRRDRsTSIKLPhosphoSitePlus
S301VSAEMsGCSSKPhosphoSitePlus
S528SSPCSsPLQGTPhosphoSitePlus
S312SHRRTsLPCIPPhosphoSitePlus; HPRD; phosphoELM; SysPTM
S438LLRRVsSTWTTPhosphoSitePlus
T615RTPSRtDDTAQHPRD
T643QNEDEtECLREPhosphoSitePlus
S465RDRSTsIKLQEPhosphoSitePlus
S613ATRTPsRTDDTPhosphoSitePlus
S478SSSPDsWNNPVPhosphoSitePlus
T442VSSTWtTTTSAPhosphoSitePlus
S408ENYTCsDSEESPhosphoSitePlus; HPRD; phosphoELM
S575SAPDLsPQILTPhosphoSitePlus
T444STWTTtTSATGPhosphoSitePlus
S527LSSPCsSPLQGPhosphoSitePlus
S550VQFPEsADTTAPhosphoSitePlus
S475EAPSSsPDSWNHPRD
S492LTKSRsFTSSYPhosphoSitePlus; HPRD
T580SPQILtPPVICPhosphoSitePlus
S439LRRVSsTWTTTPhosphoSitePlus
S524ISPLSsPCSSPPhosphoSitePlus
S523KISPLsSPCSSPhosphoSitePlus
T443SSTWTtTTSATPhosphoSitePlus
T533SPLQGtPASSLPhosphoSitePlus
S410YTCSDsEESSEHPRD; phosphoELM
S294RRRSSsVVSAEPhosphoSitePlus
T618SRTDDtAQVTSHPRD
T440RRVSStWTTTTPhosphoSitePlus; phosphoELM
S292KRRRRsSSVVSPhosphoSitePlus
S293RRRRSsSVVSAPhosphoSitePlus
T568RALTYtQSAPDPhosphoSitePlus
S428KRLRRsLPPGLPhosphoSitePlus; HPRD; phosphoELM; SysPTM
Y497SFTSSyAISAAPhosphoSitePlus
S520ALAKIsPLSSPPhosphoSitePlus; HPRD; SysPTM

Dephosphorylation site
PDE3A_HUMAN do not have dephosphorylation site.

Mutation site
Ensembl IDVariationSourceCancer namePubmed
ENSP00000351957V607LBIOMARTHepatocellular Carcinoma21930507, 21930502
ENSP00000351957G1024RCOSMICSkin Cancer21984974
ENSP00000351957A653PCOSMICOvarian Cancer21720365
ENSP00000351957K508ECOSMICHead and Neck Cancer21798893
ENSP00000351957C585FCOSMICOvarian Cancer21720365
ENSP00000351957S852TTCGAOvarian Cancer21720365, 18772890
ENSP00000351957V285LBIOMARTHepatocellular Carcinoma21930507, 21930502
ENSP00000351957V349ICOSMICHead and Neck Cancer21798897
ENSP00000351957S852TCOSMICOvarian Cancer21720365
ENSP00000351957V928FCOSMICOvarian Cancer21720365
ENSP00000351957A653PTCGAOvarian Cancer21720365, 18772890

Differential expressed protein
PDE3A_HUMAN is not differential expressed protein.

Hyperphosphorylation site
PDE3A_HUMAN do not have hyperphosphorylation site.

Direct Interaction Pair
SourceTargetRelationshipResource
AKT3_HUMANPDE3A_HUMANkinase -> substrateKEGG

Function Annotation
KEGG Pathway
KEGG IDPathway
hsa04914Progesterone-mediated oocyte maturation
hsa05032Morphine addiction
hsa04910Insulin signaling pathway
hsa00230Purine metabolism

Gene Ontology
GO IDGO_TermEvidenceOntology
GO:0043066negative regulation of apoptotic processIEAbiological_process
GO:0016021integral to membraneIEAcellular_component
GO:0004119cGMP-inhibited cyclic-nucleotide phosphodiesteraseIEAmolecular_function
GO:0006198cAMP catabolic processIDAbiological_process
GO:0030552cAMP bindingIEAmolecular_function
GO:0019934cGMP-mediated signalingIMPbiological_process
GO:0007165signal transductionIEAbiological_process
GO:0043116negative regulation of vascular permeabilityIMPbiological_process
GO:0040020regulation of meiosisIEAbiological_process
GO:0001556oocyte maturationIEAbiological_process
GO:0051591response to cAMPIEAbiological_process
GO:0060282positive regulation of oocyte developmentIEAbiological_process
GO:0007596blood coagulationTASbiological_process
GO:00041143',5'-cyclic-nucleotide phosphodiesterase activityIEAmolecular_function
GO:0019933cAMP-mediated signalingIMPbiological_process
GO:00041153',5'-cyclic-AMP phosphodiesterase activityIEAmolecular_function
GO:0046872metal ion bindingIEAmolecular_function
GO:0043117positive regulation of vascular permeabilityIMPbiological_process
GO:0016101diterpenoid metabolic processIEAbiological_process
GO:0003824catalytic activityIEAmolecular_function
GO:0042493response to drugIEAbiological_process
GO:0071321cellular response to cGMPIDAbiological_process
GO:0071560cellular response to transforming growth factor beIEPbiological_process
GO:0005829cytosolTAScellular_component
GO:0005829cytosolIEAcellular_component
GO:0006198cAMP catabolic processIEAbiological_process
GO:0006629lipid metabolic processTASbiological_process


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